Analysis of the influence of the T393C polymorphism of the GNAS gene on the clinical expression of primary hyperparathyroidism

Piedra, María; Berja, Ana; Ramos, Laura; García‐Unzueta, María Teresa; Morán, Jesús Manuel; Ruiz, David; Amado, J. A.

doi:10.1016/j.endinu.2017.08.006

Cited by 1 publication

(3 citation statements)

References 29 publications

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“…(18)(19)(20) Finally, 17 studies were included for our meta-analysis. (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37) A summary for the selection of eligible studies is depicted in the PRISMA-flow chart (Fig. 1).…”

Section: Search and Selection Of Studiesmentioning

confidence: 99%

“…Ten of the studies were conducted in Europe, five in the United States, and two in Asia. The majority of the studies were cohort (seven retrospective and eight prospective cohort studies); (21)(22)(23)(24)(25)(26)(27)(28)(30)(31)(32)(33)(34)(35)(36) the other two studies were cross-sectional (29) and case control. (37) The studies were published between 1975 and 2019.…”

Section: Study Characteristics and Quality Assessmentmentioning

confidence: 99%

“…In this meta-analysis, seven studies (26,(29)(30)(31)(32)35,36) compared BMD in patients with PHPT with the control population. All included patients and controls underwent DXA with a Hologic device.…”

Section: Secondary Outcomesmentioning

confidence: 99%

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The Risk of Fractures in Primary Hyperparathyroidism: A Meta‐Analysis

et al. 2021

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Primary hyperparathyroidism (PHPT) is a common metabolic bone disease affecting 1% of the adult population. Patients with PHPT have reduced BMD, especially at the cortical bone. However, studies evaluating its impact on fracture risk have shown contradictory results. In an effort to further inform fracture risk for this patient population, a meta‐analysis of studies of fracture in patients with PHPT compared with a control population was undertaken. Articles were searched in PubMed/MEDLINE, Excerpta Medica, Cochrane Central Register of Controlled Trials, Latin American and Caribbean Health Sciences Literature, and Web of Science bibliographic databases. The meta‐analysis included 17 studies involving 3807 PHPT cases and 11,908 controls. The primary outcome was to determine the risk of vertebral fracture (VF), nonvertebral fracture, hip fracture, distal radius fracture, and total fracture (TF) among patients with PHPT in comparison with a control population. BMD (lumbar spine, femoral neck, total hip, and distal radius) and serum 25‐hydroxy vitamin D level, as well as possible predictors of VF as secondary outcomes were assessed. From this meta‐analysis, it was found that there was a significantly increased risk of VF (risk ratio [RR], 2.57; 95% CI, 1.3–5.09; p = 0.007) and TF (RR, 1.71; 95% CI, 1.48–1.97; p < 0.00001) in patients with PHPT. There was a significant decrease in BMD in patients with PHPT versus controls at all four sites. Older age, longer duration since menopause, and lower BMD at lumbar spine and distal radius were predictors for VF. To conclude, patients with PHPT had a significantly higher risk for VF and TF in comparison with controls. © 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.

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