Analysis of the inflammatory response in endovascular treatment of aortic aneurysms

Abstract

Individual mediators analysis and inflammatory cells demonstrated variability of their values during postoperative follow-up. This could help in the analysis of the inflammatory response evolution caused by endovascular stent treatment for aortic aneurysms in premature and late phases after implantation of the vascular prosthesis.

Early pyrexia after endovascular aneurysm repair: are cultures needed?

“…1,2 Many causes have been cited including neutrophil activation by the contrast medium, 7 catheter manipulation through the aneurysm (causing endothelial activation or disturbance of the mural thrombus) 8 and splanchnic ischaemia during stent graft insertion leading to bacterial translocation and release of endotoxin and cytokines (IL-6, TNF). 9 Sac thrombosis occurs after successful exclusion of the aneurysm from the circulation and, given that venous thrombosis is well known to cause pyrexia, 10 it is likely that sac thrombosis will also contribute to post-EVAR pyrexia.…”

“…1 Although this has been shown not to be associated with stent graft or systemic infection, 2 many patients who develop a pyrexia shortly after endovascular aneurysm repair are investigated, often overnight. Presumably this is due in part to lack of awareness of the 'postimplantation syndrome' amongst juniors and non-vascular trainees.…”

Editorial commentTime course of the inflammatory response after endovascular repair of aortic aneurysms

“…In the context of the inflammatory response caused by stent-graft repair of aortic aneurysm, Gabriel et al [8] provide an interesting study looking at the time course of several relevant parameters involved in the inflammatory reaction after endovascular repair of aortic aneurysm repair. They have looked at the immediate, sub acute and late phase, changes of the different mediators and effectors of the inflammation.…”

Primeiro escore de risco inflamatório das endopróteses de aorta

“…However, there are no studies that define which inflammatory variables are elementary to the prognosis of individuals submitted to the endovascular treatment of aortic aneurisms [7].…”

“…Gabriel et al [7] recently demonstrated that the endovascular procedure for the correction of aortic aneurisms involves factors related to a systemic inflammatory response, both in the acute phase and in a later phase of the postoperative follow up. These authors postulated that inflammatory mediators, such as cytokines and cellular adhesion molecules, can be better evaluated by means of curves that register the variability of their serum levels over time.…”