Analysis of the Incidence and Survival of Gastric Cancer Based on the Lauren Classification: A Large Population-Based Study Using SEER

Abstract

Background: Limited evidence exists on the incidence of gastric cancer (GC), and contradictory results exist for the prognosis of GC based on the Lauren classification. We analyzed the incidence and survival of GC based on the Lauren classification. Methods: The Surveillance, Epidemiology, and End Results (SEER) database from 1975 through 2015 was used to identify all patients with surgically resected, histologically diagnosed intestinal or diffused-type GC. Propensity score matching was used to analyze the association between the Lauren classification type and prognosis. Results: The trend of total GC incidence showed an obvious decrease (APC = −1.51, 95% CI: −2.31 to −1.01) as well as that of the intestinal type (APC = −1.43, 95% CI: −2.01 to −1.12). However, we found that the relative incidence of the diffused type was increased (APC = 0.6, 95% CI: 0.41–0.82). The trend of the total incidence of GC (APC = −1.31, 95% CI: −1.91 to −1.03) and that of the intestinal type (APC = −1.11, 95% CI: −1.53 to −0.98) was decreased in 40–49-year-olds, but that of the diffused type was increased (APC = 1.5, 95% CI: 1.2–1.72). We found that trends in GC incidence exhibited a similar pattern in the regional and distant stages and showed a decrease from 1975 through 2015. However, the incidence rate of the local stage was increased, with an APC of 0.5 (95% CI: 0.3–0.7). We identified 15,989 GC cases from the SEER database, including 13,852 intestinal-type and 2,138 diffused-type cases. The 1,336 intestinal-type cases were matched with 1,336 diffused-type cases using propensity score matching (PSM), and patients with the diffused type had a better prognosis than patients with the intestinal type (HR = 0.56, 95% CI: 0.45–0.78). However, we found that patients with diffused-type GC had worse survival than patients with intestinal-type GC in the cohort from Renji Hospital ( P < 0.001). Conclusion: The total incidence of GC and that of the intestinal-type GC decreased, but the incidence of diffused-type GC increased in 40–49-year-olds. Diffused types of GCs may have a different prognosis compared to intestinal-type GCs in different patient cohorts. Nevertheless, these results should be interpreted with caution in assessing the prognosis in combination with other factors.

Differential prognostic implications of gastric adenocarcinoma based on Lauren’s classification: a Surveillance, Epidemiology, and End Results (SEER)-based cohort study

“…Intestinal-type gastric adenocarcinoma includes carcinoma [not otherwise specified (NOS); M8010], adenocarcinoma (NOS; M8140), tubular (M8211), and intestinal-type (M8144). Meanwhile, the diffuse type includes SRC (M8490), diffuse carcinoma (M8145), and linitis plastica (M8142) (23).…”

“…The first study by Tang et al revealed that diffuse-type early gastric cancer (EGC) had a better prognosis than intestinal-type EGC by using PSM for adjusting confounders. However, after matching, only 2,672 cases were included in their study, which might weaken the whole sample's representativeness (23). Herein, we performed multivariate regression first and then conducted PSM, and established a competing risk model to perform sensitivity analysis.…”

Bioinformatics analysis identifies biomarkers associated with poor prognosis in diffuse‑type gastric cancer

“…Diffuse-type GC is more likely in women and younger patients and has a lower 5-year survival rate (10)(11)(12). Mix-type has the highest degree of malignancy due to variable biological behavior (13).…”

TP53 mutation and MET amplification in circulating tumor DNA analysis predict disease progression in patients with advanced gastric cancer

“…All the pathological types were adenocarcinoma, with 7 cases of liver metastasis and 4 cases of peritoneal metastasis. According to lauren classification (Tang et al, 2020) , 5 cases were classified as diffuse-type and 18 other types. Of these patients, 12 had undergone radical surgery, 4…”