Analysis of the impact of allergy and atopy on new onset of uveitis

Grajewski, Rafael S.; Pour, Niusha Barahmand; Burian, K; Caramoy, Albert; Kirchhof, Bernd; Cursiefen, Claus; Heindl, Ludwig M.

doi:10.1111/aos.13239

Cited by 5 publications

(4 citation statements)

References 21 publications

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“…A recent analysis (2012-2014) did not demonstrate a statistically significant correlation between the impact of atopy and the onset of uveitis (p = 0.494) [58].…”

Section: Uveitismentioning

confidence: 87%

Ophthalmic manifestations of atopic dermatitis

Pietruszyńska¹,

Zawadzka-Krajewska²,

Duda³

et al. 2020

pdia

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Atopic dermatitis is a chronic condition of complex etiology, whose clinical course involves remission and recurrence. It is not an isolated disease entity affecting only the skin, but one that co-occurs with disorders of other organs. Numerous literature reports have long confirmed the relationship between the disorder and a growing number of ophthalmic manifestations such as keratoconus and retinal detachment. Further studies are required to establish the cause of correlations and to allow for implementation of appropriate prophylaxis and treatment. The aim of the present paper is to review published literature regarding the correlation between atopic dermatitis and ophthalmic manifestations in adults and children.

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“…A recent analysis (2012-2014) did not demonstrate a statistically significant correlation between the impact of atopy and the onset of uveitis (p = 0.494) [58].…”

Section: Uveitismentioning

confidence: 87%

Ophthalmic manifestations of atopic dermatitis

Pietruszyńska¹,

Zawadzka-Krajewska²,

Duda³

et al. 2020

pdia

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“…Among these, evidence suggests that cataract surgery is causally involved in RRD occurrence in children; in recent study, a 5.5% risk for RRD is estimated within first 10 years after cataract surgery in childhood [ 12 , 36 ]. It is also known that cataract is one of the various complications of uveitis [ 37 , 38 ]. In addition, CTD is frequently accompanied by uveitis, and cataract may be caused by steroids, which are mainly used for the treatment of CTD [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

The Association with rhegmatogenous retinal detachment and paediatric atopic dermatitis: a 12-year Nationwide Cohort Study

Choi

Byun

Lee

et al. 2020

Eye

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Purpose Historically, atopic dermatitis (AD) is associated with an increased risk of rhegmatogenous retinal detachment (RRD). However, uncertainty remained regarding the effect of AD itself and comorbidities (e.g., allergic diseases, cataract surgery) on RRD occurrence in a large, population-based paediatric population. Patients and methods We analysed the 12-year National Health Insurance Service database (2002–2013) covering the entire Korean population to estimate the association between AD and RRD in people aged under 20 years. Results We identified 3142 RRD patients, and matched 18,852 controls (six controls to each RRD patient); therefore, we included 21,994 peoples under aged 20 years in the analyses. AD was more prevalent in the RRD group (329 patients, 10.47%) than the control group (1043 patients, 5.53%; P < 0.001), and so were severe AD (153 patients [4.87%] and 223 patients [1.18%], respectively; P < 0.001). In conditional logistic regression analysis, AD was associated with RRD (OR, 1.61; 95% CI, 1.93–1.87) even after adjusting for allergic conditions, connective tissue disease, uveitis, and cataract surgery. In addition, severity of AD was associated with an increased risk of RRD (OR for non-severe AD and severe AD, 1.26 [95% CI, 1.05–1.51] and 2.88 [95% CI, 2.25–3.68]). Conclusion This study suggests that AD itself is a risk factor of RRD in children by showing the association between AD and RRD occurrence and the biologic gradient even after adjustment for known confounders including allergic conditions, uveitis, and cataract surgery.

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“…Uveitis was not detected in any of our patients either. Likewise, an article about the impact of allergy and atopy on new onset of uveitis in Germany demonstrated that there is no significant correlation between atopy and new onset of uveitis [26] . Atopy seems to be an important factor in the occurrence of keratoconus [27] .…”

Section: Discussionmentioning

confidence: 99%

Ocular manifestations of children with atopic dermatitis in Saudi Arabia

Raffa¹,

Balbaid²,

Zimmo³

et al. 2023

Int J Ophthalmol

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AIM: To examine the incidence of ocular abnormalities in children with atopic dermatitis (AD) in Saudi Arabia and its association with the severity of AD. METHODS: This is a cross-sectional study on 50 children with AD who were between 5 and 16 years of age. The severity of AD was evaluated using the SCORing Atopic Dermatitis (SCORAD) index. All the children underwent slit lamp exams, visual acuity assessment, intraocular pressure measurement, and corneal topography. The children were considered to have an ophthalmic abnormality if one or more of the following signs were present: glaucoma, keratoconus suspicion, in addition to lid, conjunctival, corneal, lenticular, or retinal abnormalities. RESULTS: Based on the SCORAD severity index, 14% of children had mild AD (7/50), 38% had moderate AD (19/50), and nearly half had severe AD. More than half the children exhibited facial involvement, and half had peri-orbital signs. The mean SCORAD index was 35.75. The mean age was 10.48±3.6y, and the cohort showed a slight male predominance (54% males). Both eyes of the 50 children in the cohort were studied. Based on the ocular examinations, 92% of the patients showed ocular abnormalities: lid abnormalities (27/50) followed by keratitis (22/50). Four patients had moderate risk for keratoconus in one eye and eight patients were suspected to have keratoconus. However, SCORAD severity index was not associated with age, sex, or the number or presence of ophthalmic abnormalities. CONCLUSION: This is the first study in Saudi Arabia to evaluate the prevalence of ocular manifestations in children with AD. The results indicate that the majority of children with AD have ocular abnormalities that mainly include lid abnormalities. Based on these findings, larger scale studies are needed to affirm whether regular screening for ophthalmic abnormalities would be beneficial for children with AD in terms of early intervention and prevention of sight-threatening complications.

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Analysis of the impact of allergy and atopy on new onset of uveitis

Abstract: Our results argue against a substantial influence of allergies and atopy on the onset of uveitis.

Cited by 5 publications

References 21 publications

Ophthalmic manifestations of atopic dermatitis

Ophthalmic manifestations of atopic dermatitis

The Association with rhegmatogenous retinal detachment and paediatric atopic dermatitis: a 12-year Nationwide Cohort Study

Ocular manifestations of children with atopic dermatitis in Saudi Arabia

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