Analysis of the Gonadal Sex of Five Intersex Pigs Using Y Chromosomal Markers

Thomsen, Preben D.; Poulsenm, P. H.

doi:10.1111/j.1601-5223.1993.00205.x

Cited by 15 publications

(2 citation statements)

References 11 publications

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“…true hermaphroditism, male pseudohermaphroditism, female pseudohermaphroditism and males with or without sexual ambiguities). In some of these cases, complementary molecular analyses revealed the lack of specific Y chromosome sequences (including the SRY gene) [Thomsen and Poulsen, 1993;Pailhoux et al, 1994Switonski et al, 2002]. Female karyotypes and lack of the SRY gene were also observed in other species as illustrated in this article.…”

Section: Chromosomal Complementsmentioning

confidence: 81%

Classical and Molecular Cytogenetics of Disorders of Sex Development in Domestic Animals

Villagómez

Parma

Radi

et al. 2009

Cytogenet Genome Res

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The association of abnormal chromosome constitutions and disorders of sex development in domestic animals has been recorded since the beginnings of conventional cytogenetic analysis. Deviated karyotypes consisting of abnormal sex chromosome sets (e.g. aneuploidy) and/or the coexistence of cells with different sex chromosome constitutions (e.g. mosaicism or chimerism) in an individual seem to be the main causes of anomalies of sex determination and sex differentiation. Molecular cytogenetics and genetics have increased our understanding of these pathologies, where human and mouse models have provided a substantial amount of knowledge, leading to the discovery of a number of genes implicated in mammalian sex determination and differentiation. Additionally, other genes, which appeared to be involved in ovary differentiation, have been found by investigations in domestic species such as the goat. In this paper, we present an overview of the biology of mammalian sex development as a scientific background for better understanding the body of knowledge of the clinical cytogenetics of disorders of sex development in domestic animals. An attempt to summarize of what has been described in that particular subject of veterinary medicine for each of the main mammalian domestic species is presented here.

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Section: Chromosomal Complementsmentioning

confidence: 81%

Classical and Molecular Cytogenetics of Disorders of Sex Development in Domestic Animals

Villagómez

Parma

Radi

et al. 2009

Cytogenet Genome Res

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“…The same incidence has been reported in XX sex reversal mice, but this translocation has not yet been identified in dogs or pigs. In these latter species, all XX sex reversal cases have been SRY negative (Thomsen and Poulsen ; Meyers‐Wallen et al. ; Meyers‐Wallen ).…”

Section: Discussionmentioning

confidence: 99%

First Description of Scrotal Testicles in a Dog Affected by 78, XX Testicular Disorder of Sex Development

Carro

Rosset

Josson-Schramme

et al. 2014

Reprod Domestic Animals

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An eight-month-old female dog presented with ambiguous external genitalia. A thorough clinical examination together with various imaging techniques and a histology examination showed the presence of two testicles linked to both the Mullerian and Wolffian ducts. The discovery of the 78,XX SRY-negative karyotype led to the diagnosis of incoherence between the chromosomal and gonadal sex, which is typical for a 78,XX testicular disorder of sex development. Our case was unique because the testicles were still located in their normal scrotal position, whereas the literature contains reports of the presence of cryptorchid testicles in this karyotype setting. To our knowledge, this is the first case that describes an SRY-negative 78,XX testicular disorder of sex development with bilateral scrotal testicles.

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Aetiology of intersexuality in female (XX) pigs, with novel molecular interpretations

Hunter

1996

Mol. Reprod. Dev.

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Analysis of the Gonadal Sex of Five Intersex Pigs Using Y Chromosomal Markers

Cited by 15 publications

References 11 publications

Classical and Molecular Cytogenetics of Disorders of Sex Development in Domestic Animals

Classical and Molecular Cytogenetics of Disorders of Sex Development in Domestic Animals

First Description of Scrotal Testicles in a Dog Affected by 78, XX Testicular Disorder of Sex Development

Aetiology of intersexuality in female (XX) pigs, with novel molecular interpretations

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