Analysis of the gamete-fusion genes in the haploid-inducing ZMS-P maize line

Moiseeva, Ye. M.; Volokhina, I. V.; Gusev, Yu. S.; Gutorova, O. V.; Chumakov, M. I.

doi:10.1134/s1062360417020096

Cited by 6 publications

(1 citation statement)

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“…a unilateral requirement in male gametes (Hirai et al, 2008;Liu et al, 2008;Orias, 2014;von Besser et al, 2006;. However, HAP2 has also been detected in ovules in Arabidopsis and maize (Borges et al, 2008;Moiseeva et al, 2017). Conflicting views have also been reported for Chlamydomonas: most studies suggest that HAP2 is present only in the mt− gamete, but low expression levels have been detected in the mt+ gamete (Mori et al, 2006).…”

Section: Hap2 In Gametes: Cell Fusion With Unilateral and Bilateral Rmentioning

confidence: 99%

The hallmarks of cell-cell fusion

2017

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Cell-cell fusion is essential for fertilization and organ development. Dedicated proteins known as fusogens are responsible for mediating membrane fusion. However, until recently, these proteins either remained unidentified or were poorly understood at the mechanistic level. Here, we review how fusogens surmount multiple energy barriers to mediate cell-cell fusion. We describe how early preparatory steps bring membranes to a distance of ∼10 nm, while fusogens act in the final approach between membranes. The mechanical force exerted by cell fusogens and the accompanying lipidic rearrangements constitute the hallmarks of cell-cell fusion. Finally, we discuss the relationship between viral and eukaryotic fusogens, highlight a classification scheme regrouping a superfamily of fusogens called Fusexins, and propose new questions and avenues of enquiry.

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