Analysis of the Functional Aspects of Sperm and Testicular Oxidative Stress in Individuals Undergoing Metabolic Surgery

Fariello, R.M.; Carvalho, Renata Cristina de; Spaine, D.M.; Andretta, Rhayza Roberta; Caetano, E. M.; Sá, Gustavo; Cedenho, A.P.; Fraietta, Renato

doi:10.1007/s11695-021-05350-9

Cited by 13 publications

(9 citation statements)

References 47 publications

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“…However, Fariello et al. ( 37 ) revealed that testicular oxidative stress decreased after weight loss 6 months postoperatively, and both seminal quality and sex hormone profile improved.…”

Section: Discussionmentioning

confidence: 99%

Effects of bariatric surgery on testosterone level and sexual function in men with obesity: A retrospective study

et al. 2023

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IntroductionBariatric surgeries induce well-documented weight loss and resolve obesity comorbidities. Sexual function is one of the aspects of life quality and may benefit from surgery. Few studies have revealed the impact of bariatric surgeries on sexual function in Chinese men with obesity.MethodsThis is a retrospective cohort study of patients undergoing bariatric surgery [laparoscopic sleeve gastrectomy (LSG) or laparoscopic Roux-en-Y gastric bypass (LRYGB)]. Data were collected between September 2017 and February 2022. The International Index of Erectile Function (IIEF) questionnaire was used to evaluate erectile function, intercourse satisfaction, orgasmic function, sexual desire, and overall satisfaction. Sex hormones and other blood tests were evaluated before and at least 1 year after the surgery.ResultsFifty-nine Chinese male patients completed the IIEF questionnaire. The multivariate logistic regression analysis revealed that body mass index (BMI) was the single independent risk factor of the severity of erectile dysfunction (ED). Preoperative testosterone levels had negative correlations with BMI and waist circumference. Thirty-seven patients completed the postoperative questionnaire with a mean follow-up of 23.2 months.ConclusionBMI and waist circumference were negatively correlated with testosterone levels. BMI was an independent risk factor for the severity of ED. LSG and LRYGB led to positive and sustained improvement in sexual function of men with obesity. The two procedures had a comparable effect, more subjects being needed. Sex hormone levels also could be reversible. However, more weight loss did not predict a positive change in sexual function. A greater BMI loss might predict a greater increase in testosterone.

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“…However, Fariello et al. ( 37 ) revealed that testicular oxidative stress decreased after weight loss 6 months postoperatively, and both seminal quality and sex hormone profile improved.…”

Section: Discussionmentioning

confidence: 99%

Effects of bariatric surgery on testosterone level and sexual function in men with obesity: A retrospective study

et al. 2023

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“…The radical oxygen reactive species (ROS) includes a hydroxyl ion (OH − ), hydrogen peroxide (H 2 O 2 ) and a superoxide anion (O 2 − ). During obesity, oxidative stress in the testis of males is heightened, as seen in both clinical [ 27 , 28 ] and experimental studies [ 29 , 30 , 31 ]. Likewise, inflammation plays a role in testicular dysfunction because of the imbalance between the pro-inflammatory and anti-inflammatory cytokines [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Effects of Bee Bread on Obesity-Induced Testicular-Derived Oxidative Stress, Inflammation, and Apoptosis in High-Fat Diet Obese Rat Model

et al. 2022

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Obesity is a debilitating disorder with a variety of problems including oxidative stress, inflammation, and apoptosis. The aim of our study was to investigate the therapeutic role of bee bread on oxidative stress, apoptosis, and inflammation in the testis of obese rats. Thirty-two adult male Sprague Dawley rats, with weights between 230–300 g, were distributed into four groups (n = 8/group), namely normal control (C), obese (Ob), obese + BB or obese + OR [high-fat diet (HFD) for 6 weeks then HFD plus bee bread or orlistat for another 6 weeks] groups. Bee bread (0.5 g/kg) or orlistat (10 mg/kg/day) was diluted with distilled water and administered daily for 6 weeks by oral gavage. There were significant decreases in the activities of antioxidant enzymes [glutathione-S-transferase (GST), superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), glutathione reductase (GR)], glutathione (GSH)] and total antioxidant capacity (TAC) levels and mRNA expressions of nuclear factor erythroid 2–related factor 2 (Nrf2), superoxide dismutase (Sod), catalase (Cat) and glutathione peroxidase (Gpx) in the obese group relative to the control group. Meanwhile, the mRNA levels of pro-inflammatory markers, namely: inducible nitric oxide synthase (Inos), nuclear factor kappa B (Nf-κβ), tumour necrotic factor α (Tnf-α) and interleukin 1β (Il-1β) were significantly increased while interleukin (Il-10) was decreased in the obese group relative to the control group. Further, proliferating cell nuclear antigen (PCNA) immunoexpressions decreased while cleaved caspase-3 immunohistochemical staining increased significantly in the obese group, in addition to increases in the mRNA levels of p53, Bax, Caspases-8, 9 and 3, relative to the control group. Treatment with bee bread showed increases in antioxidant enzymes and PCNA immunoexpression, as well as decreases in inflammation and apoptosis markers in the testes. This study has shown that bee bread has therapeutic effects against oxidative stress, inflammation, apoptosis in the testis of HFD-induced obese male rats, thereby suggesting its role as a natural supplement capable of treating obesity-induced male reproductive impairment.

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“…Nutritional deficiency of vitamins and minerals, including iron and calcium, are crucial for spermatogenesis, and therefore the lack thereof may lead to the insignificant improvement on sperm quality parameters. In our analysis, the prospective study, Fariello et al (N = 15) did not show significant improvement in the 12th postoperative month in all sperm parameters [ 18 ]. Whether bariatric surgery improves sperm parameters is controversial and requires further research.…”

Section: Discussionmentioning

confidence: 54%

The effects of bariatric surgery on male and female fertility: A systematic review and meta-analysis

Qurashi

Qadri

Lund

et al. 2022

Annals of Medicine &Amp; Surgery

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Analysis of the Functional Aspects of Sperm and Testicular Oxidative Stress in Individuals Undergoing Metabolic Surgery

Cited by 13 publications

References 47 publications

Effects of bariatric surgery on testosterone level and sexual function in men with obesity: A retrospective study

Effects of bariatric surgery on testosterone level and sexual function in men with obesity: A retrospective study

Therapeutic Effects of Bee Bread on Obesity-Induced Testicular-Derived Oxidative Stress, Inflammation, and Apoptosis in High-Fat Diet Obese Rat Model

The effects of bariatric surgery on male and female fertility: A systematic review and meta-analysis

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