Analysis of the Factors Influencing the Development of Hand-foot Syndrome in Patients Receiving Pegylated Liposomal Doxorubicin Therapy for Ovarian Cancer
Abstract:Pegylated liposomal doxorubicin (PLD) is a liposomal formulation of doxorubicin hydrochloride. It was approved for the treatment of ovarian cancer aggravated after chemotherapy. The occurrence of hand-foot syndrome (HFS) associated with the administration of PLD is considered one of the major adverse side effects. The development of Grade2 ≦ HFS (Serious HFS) during the course of PLD therapy calls for dose reduction or discontinuation of subsequent PLD administration. However, the factors that influence the de… Show more
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