Analysis of the factors affecting outcome after combat-related cranial defect reconstruction

Pavlićević, Goran; Lepić, Milan; Peric, Predrag; Ivetić, Dražen; Roganović, Ana; Roganović, Z

doi:10.1016/j.jcms.2016.11.019

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…Any trauma to the head requiring cranioplasties is at increased risk of failure if the defect is large with poor soft tissue coverage and infection. 18 When alloplastic implants are used, their risk of failure is increased when there is a connection with the orbit or extension into the sinuses, both introducing infection. 19 The limitations of alloplastic materials underline the need for further research in developing autologous means to reconstruct critical cranial defects.…”

Section: Critical Size Defects In the Craniofacial Bonementioning

confidence: 99%

The Role of Skeletal Stem Cells in the Reconstruction of Bone Defects

Murphy

Irizarry²,

Lopez

et al. 2017

Journal of Craniofacial Surgery

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Craniofacial surgery, since its inauguration, has been the culmination of collaborative efforts to solve complex congenital, dysplastic, oncological, and traumatic cranial bone defects. Now, 50 years on from the first craniofacial meeting, the collaborative efforts between surgeons, scientists, and bioengineers are further advancing craniofacial surgery with new discoveries in tissue regeneration. Recent advances in regenerative medicine and stem cell biology have transformed the authors' understanding of bone healing, the role of stem cells governing bone healing, and the effects of the niche environment and extracellular matrix on stem cell fate. This review aims at summarizing the advances within each of these fields.

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Section: Critical Size Defects In the Craniofacial Bonementioning

confidence: 99%

The Role of Skeletal Stem Cells in the Reconstruction of Bone Defects

Murphy

Irizarry²,

Lopez

et al. 2017

Journal of Craniofacial Surgery

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“…Recently, however, one Serbian center described a series of cranioplasty patients with greater than 5 years of followup who have been treated with either autografts or allografts. [35] In their work, cadaveric allografts demonstrated an infection rate twice as high as autografts at 13.2% but otherwise had reasonable outcomes.…”

Section: Challenges In Cranial Defect Reconstructionmentioning

confidence: 99%

Bioinspired Collagen Scaffolds in Cranial Bone Regeneration: From Bedside to Bench

Lee

Volpicelli

2017

Adv Healthcare Materials

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Calvarial defects are common reconstructive dilemmas secondary to a variety of etiologies including traumatic brain injury, cerebrovascular disease, oncologic resection, and congenital anomalies. Reconstruction of the calvarium is generally undertaken for the purposes of cerebral protection, contour restoration for psychosocial well-being, and normalization of neurological dysfunction frequently found in patients with massive cranial defects. Current methods for reconstruction using autologous grafts, allogeneic grafts, or allo-plastic materials have significant drawbacks that are unique to each material. The combination of wide medical relevance and the need for a better clinical solution render defects of the cranial skeleton an ideal target for development of regenerative strategies focused on calvarial bone. With the improved understanding of the instructive properties of tissue-specific extracellular matrices and the advent of precise nanoscale modulation in materials science, strategies in regenerative medicine have shifted in paradigm. Previously considered to be simple carriers of stem cells and growth factors, increasing evidence exists for differential materials directing lineage specific differentiation of progenitor cells and tissue regeneration. In this work, we review the clinical challenges for calvarial reconstruction, the anatomy and physiology of bone, and extracellular matrix-inspired, collagen-based materials that have been tested for in vivo cranial defect healing.

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