Analysis of the expression of heat‐shock protein 27 in patients with oral lichen planus

García-García, Virginia; Bascones-Martínez, A.; García-Kass, AI; Martinelli-Kläy, C. P.; Küffer, R; Álvarez-Fernández, Emilio; Lombardi, Tommaso

doi:10.1111/j.1601-0825.2012.01951.x

Cited by 8 publications

(7 citation statements)

References 52 publications

(75 reference statements)

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“…Proposed activation/tolerance theories regarding dendritic cells-i.e., that stimulatory function is either enhanced by toll-like receptors on dendritic cells recognizing microbial products and upregulating costimulatory molecules (47) or that damage in other cells and production of molecules such as heat shock proteins act as "danger signals" (48) that activate dendritic cells-may also be true for epithelial cells (49)(50)(51)(52).…”

Section: Discussionmentioning

confidence: 99%

Immune receptors CD40 and CD86 in oral keratinocytes and implications for oral lichen planus

et al. 2017

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Lichen planus (LP) is a chronic T-cell-mediated mucocutaneous inflammatory disease that targets stratified epithelia, including those lining the oral cavity. The intraoral variant of LP (OLP) is associated with interferon (IFN)-γ production by infiltrating T lymphocytes; however, the role of epithelial cells in the etiopathogenesis OLP is not completely understood. There is however a growing body of evidence regarding the involvement of epithelial-derived cytokines, immune receptors, and costimulatory molecules in the pathobiological processes that promote and sustain OLP. In the present study, we used a reverse transcriptase-polymerase chain reaction assay to assess whether CD40-a receptor found mainly on antigen presenting cells-and the costimulatory molecule CD86 were expressed in oral keratinocytes (three strains of primary normal oral keratinocytes and the H357 cell line) in the presence or absence of IFN-γ. To further characterize the involvement of CD40 in OLP, expression and distribution of receptor and ligand (CD40/CD154) in tissues from OLP were evaluated by immunohistochemistry. The present results are the first to show that both CD40 and CD86 are constitutively expressed at low levels in oral keratinocytes and that their expression was enhanced by IFN-γ stimulation. The intensity of CD40 staining in OLP tissues was strong. Taken together, the results strongly suggest that CD40 and CD86 play a role in the pathophysiology of oral inflammatory diseases such as OLP.

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Section: Discussionmentioning

confidence: 99%

Immune receptors CD40 and CD86 in oral keratinocytes and implications for oral lichen planus

et al. 2017

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“…The cicatricial post‐lichen stage is permanent and does not respond to medical treatment. Its importance lies in the possibility of progressive malignant transformation during the preceding stages of OLP, which persists in the atrophic and fibrous mucosa . At this point, it is important to mention that there exists controversy regarding OLP malignant transformation probably due to variations in the diagnostic criteria and knowledge of the post‐lichen stage.…”

Section: Oral Manifestations Of Immune‐mediated Diseasesmentioning

confidence: 99%

Immune‐mediated diseases: what can be found in the oral cavity?

et al. 2014

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Immune-mediated diseases frequently affect oral mucosa, which may often be the first site of clinical manifestation. In this review, we describe the most important oral lesions related to inflammatory disorders and present their management and novel therapies. The review is based on an open PubMed literature search from 1980 to 2012 with relevant keywords. Pemphigus vulgaris, oral lichen planus, cicatricial pemphigoid, erythema multiforme, Stevens-Johnson syndrome, systemic lupus erythematosus, Sjögren's syndrome, and linear IgA dermatosis are the immune-mediated diseases with oral manifestations discussed. Etiology is unknown in most of these diseases, but recently some of them have been found to share common genes. Modern treatment of these diseases is based on drugs that interfere along the pathogenic mechanisms instead of the still commonly used palliative measures. However, the immunomodulatory drugs may also cause oral side effects, complicating the clinical picture. Therefore, consulting dental or oral medicine specialists can be necessary in some cases with various immune-mediated diseases.

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“…The main progressive changes occurring in CKD include the action of uraemic toxins, inflammation, increase in apoptosis and an impairment of immunity (Musial and Zwolinska, 2011), whereas in OLP, they consist, mainly, in epithelial atrophy, hyperkeratosis and fibrosis of the corium. In both diseases, there is an increased possibility for malignant transformation in the late stages (Stewart et al, 2009;Garcia-Garcia et al, 2012).…”

Section: Dear Editormentioning

confidence: 99%

Reply to the Letter to the Editor entitled: ‘Hsp 27 as a potential preneoplastic marker in patients with chronic kidney disease (CKD)’

García-García¹,

Bascones-Martínez²,

Martinelli-Kläy³

et al. 2012

Oral Diseases

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Analysis of the expression of heat‐shock protein 27 in patients with oral lichen planus

Abstract: The increased expression of Hsp27 in the basal layer observed during the OLP evolution and the less staining in the superficial layers in all cases of OLP suggest that hsp27 may have a role in the OLP pathogenesis.

Cited by 8 publications

References 52 publications

Immune receptors CD40 and CD86 in oral keratinocytes and implications for oral lichen planus

Immune receptors CD40 and CD86 in oral keratinocytes and implications for oral lichen planus

Immune‐mediated diseases: what can be found in the oral cavity?

Reply to the Letter to the Editor entitled: ‘Hsp 27 as a potential preneoplastic marker in patients with chronic kidney disease (CKD)’

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