Analysis of the expression of plasma omentin-1 level in colorectal cancer and its correlation with prognosis

Abstract

Background: Colorectal cancer (CRC) is a malignant tumor of the digestive tract, with high incidence and mortality. This study aims to investigate the expression of plasma omentin-1 level in patients with CRC and its correlation with the prognosis of patients.Methods: Clinical data of 319 patients (case group) who underwent radical resection of CRC in our hospital from June 2015 to March 2018 were collected, simultaneously, 300 people without the apparent physical disease who underwent physical examination in our hospital during the same period were randomly selected as the control group, plasma omentin-1 levels in the two groups were compared by T-test. Cancer patients were followed up, and multi-factor COX regression analysis was used to analyze the factors affecting patients' recurrence and survival. Results:The level of plasma omentin-1 in patients with colorectal cancer is closely related to TNM staging and lymph node metastasis. The CRC case group was significantly reduced after surgery, but it was still higher than that in the control group (P<0.05). At the end of the follow-up, 28 cases were lost to followup, and 291 cases (91.22%) were effectively followed up. During the follow-up period, the recurrence and metastasis rate was 30.58% (89/291), and the mortality rate was 19.26% (56/291). According to the multifactor analysis, the risk factors for the recurrence of CRC patients were TNM stage III-IV (OR =1.978, 95% CI: 1.088-3.596), lymph node metastasis (OR =2.073, 95% CI: 1.179-3.645) and omentin-1 level ≥50 ng/mL (OR =3.347,. The risk factors for the survival of patients with CRC were poorly differentiated (OR =1.960, 95% CI: 0.985-3.900), lymph node metastasis (OR =2.452, 95% CI: 1.213-4.956), vascular carcinoma thrombus (OR =2.026, 95% CI: 1.036-3.960) and omentin-1 level ≥50 ng/mL (OR =2.067, 95% CI: 1.013-4.218). Conclusions:The level of plasma omentin-1 is highly expressed in patients with CRC, an independent risk factor for the recurrence and survival of patients.

The Emerging Role of Intelectin-1 in Cancer

“…Another study evaluating a cohort of Chinese patients identified increased ITLN1 levels as a potential risk factor for colorectal cancer (13). Higher levels of circulating ITLN1 were also found to increase the probability of recurrence or death in colorectal cancer after surgery; yet, the difference in circulating ITLN1 between the groups was very small (14). A study by Ummugul Uyeturk and colleagues (15) examined circulating ITLN1 levels after surgery and chemotherapy in colorectal cancer and found that the levels remained elevated compared with a healthy control group who did not have surgery or chemotherapy.…”

Colorectal Cancer Cell Differentiation Trajectory Predicts Patient Immunotherapy Response and Prognosis

“…According to a number of studies, plasma ITLN1 is highly expressed in CRC patients and is an independent risk factor for recurrence and survival. 61 In contrast, Katsuya et al 62 found that enhanced tumor expression of ITLN1 was associated with a more favorable prognosis in CRC patients. In this study, MMP1, LGALS4, and ITLN1 were low-risk genes associated with a good prognosis.…”

The Role of Adipokines in Tumor Progression and Its Association with Obesity

“…Levels of omentin-1, whether low or high, could potentially serve as indicators of cancer progression, with some data suggesting an association between increased omentin levels in blood serum and cancer development [49]. Conversely, other data propose a potential decrease in omentin concentration with the malignancy of cancer [50].…”