“…Broad functionality of the members of BTN family that ranges from the crucial roles in the formation, secretion, and stabilization of milk fat globules to regulation of the immune response [ 5 ], association of these proteins with various human pathologies, such as autoimmune diseases [ 75 , 76 ], cardiovascular disease [ 77 , 78 , 79 ], Kawasaki disease [ 80 ], diabetes [ 76 , 81 ], sarcoidosis [ 82 , 83 , 84 ], multiple sclerosis [ 85 , 86 ], and cancer [ 87 , 88 , 89 , 90 , 91 , 92 ], to name a few, and their ability to protect infants against various human pathogens [ 93 ] clearly put butyrophilins to the category of moonlighting proteins. The capability of a protein to have multiple unrelated biological functions (i.e., to be a moonlighting protein) is commonly associated with the presence of intrinsically disordered protein regions (IDPRs) [ 37 , 39 , 49 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 ].…”