Analysis of the efficiency of the application of cell therapy for local radiation injurie

Abstract

Every year the proportion of radiation therapy as an independent method of radical treatment of cancer patients is increasing. Exposure to radiation as a result of medical treatment can lead to the development in patients of local radiation injuries (LRJ) (radiation reactions) on the skin and surrounding tissues. Today, there is no standard treatment for LRJ, known methods are ineffective In this regard, research aimed at finding effective methods of treatment leading to accelerated wound healing, a decrease in inflammation and a decrease in fibrosis is relevant. In recent years, there has been an active study of the effectiveness of the use of cell therapy, including mesenchymal stem cells, their cell products, minimally manipulated cell products, etc., in complex therapy for local radiation injuries. In the presented literature review, the effectiveness of the use of cellular products in local radiation damage to the skin caused by sources of ionizing radiation is considered. Bibliographic searches of works were carried out on the basis of the PubMed portal, published in the period from 2015 to August 2020.