Analysis of the Effects of Antibodies to Gangliosides on the Electrical Activity of Retzius Neurons in the Leech and on the Functional Activity of Influx Sodium Current Channels
Abstract:The effects of anti-ganglioside antibodies on the functional states of two types of influx Na+ current channels were studied. Experiments used 20% anti-ganglioside antiserum prepared by standard methods by immunizing rabbits with total bovine brain gangliosides. These experiments showed that incubation of neurons in physiological saline containing antiserum induced discordance in the operation of the two types of influx current Na+ channels responsible for spike generation. This reaction was found to be associ… Show more
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