Analysis of the effect of formulation properties and process parameters on granule formation in twin-screw wet granulation

Peeters, Michiel; Barrera Jiménez, Ana Alejandra; Matsunami, Kensaku; Ghijs, Michael; dos Santos Schultz, Eduardo; Roudgar, Mina; Vigh, Tamas; Stauffer, Fanny; Nopens, Ingmar; De Beer, Thomas

doi:10.1016/j.ijpharm.2023.123671

Cited by 5 publications

(1 citation statement)

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“…Recent research has indicated that augmenting the thickness of the binder can result in the creation of denser and more enduring liquid connections between the particles. This, in turn, enhances the strength of the granules [ 24 ]. Nevertheless, the heightened thickness of the granulating liquid can also cause a reduction in its ability to distribute evenly, resulting in uneven wetness and the creation of specific areas that are excessively wet [ 19 ].…”

Section: Twin-screw Granulationmentioning

confidence: 99%

Process Simulation of Twin-Screw Granulation: A Review

Arthur,

Rahmanian

2024

Pharmaceutics

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Twin-screw granulation has emerged as a key process in powder processing industries and in the pharmaceutical sector to produce granules with controlled properties. This comprehensive review provides an overview of the simulation techniques and approaches that have been employed in the study of twin-screw granulation processes. This review discusses the major aspects of the twin-screw granulation process which include the fundamental principles of twin-screw granulation, equipment design, process parameters, and simulation methodologies. It highlights the importance of operating conditions and formulation designs in powder flow dynamics, mixing behaviour, and particle interactions within the twin-screw granulator for enhancing product quality and process efficiency. Simulation techniques such as the population balance model (PBM), computational fluid dynamics (CFD), the discrete element method (DEM), process modelling software (PMS), and other coupled techniques are critically discussed with a focus on simulating twin-screw granulation processes. This paper examines the challenges and limitations associated with each simulation approach and provides insights into future research directions. Overall, this article serves as a valuable resource for researchers who intend to develop their understanding of twin-screw granulation and provides insights into the various techniques and approaches available for simulating the twin-screw granulation process.

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Section: Twin-screw Granulationmentioning

confidence: 99%