Analysis of the effect of perioperative magnesium sulphate on minimal alveolar concentration of desflurane using bispectral index monitoring

Tomak, Yakup; Tekïn, Murat; Katı, İsmail; Belenli, Ceyda; Aydoğmuş, Meltem Türkay

doi:10.1684/mrh.2011.0294

Cited by 4 publications

(8 citation statements)

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“…There are some limitations to the present study. First, previous reports using bispectral index monitoring in adults demonstrated that intra‐operative magnesium sulphate administration is associated with significant reduction in intravenous and inhalational anaesthetic requirements and a slower postoperative recovery. Bispectral index monitoring was not used in the present study and sevoflurane concentration was maintained in the same range in the two study groups.…”

Section: Discussionmentioning

confidence: 99%

The effect of magnesium sulphate infusion on the incidence and severity of emergence agitation in children undergoing adenotonsillectomy using sevoflurane anaesthesia

et al. 2013

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SummaryThis randomised, controlled, double-blind study investigated the effects of intra-operative magnesium sulphate administration on the incidence of emergence agitation in children undergoing adenotonsillectomy using sevoflurane anaesthesia. Seventy children were randomly allocated to receive a 30 mg.kg À1 bolus of intravenous magnesium sulphate after induction of anaesthesia followed by a continuous infusion of 10 mg.kg À1 .h À1 or an equal volume of saline 0.9%. All children received titrated sevoflurane anaesthesia adjusted to maintain haemodynamic stability. The Pediatric Anesthesia Emergence Delirium scale and the Children's Hospital of Eastern Ontario Score were used for the assessment of postoperative emergence agitation and pain, respectively. Emergence agitation was more common in the control group than in the magnesium group (23 (72%) and 12 (36%), respectively (p = 0.004)), with a relative risk of 0.51 (95% CI 0.31-0.84), an absolute risk reduction of 0.35 (95% CI 0.10-0.54), and number needed to treat of 3 (95% CI 2-9). Postoperative pain scores were comparable in the two groups. Magnesium sulphate reduces the incidence and severity of emergence agitation in children undergoing adenotonsillectomy using sevoflurane anaesthesia and is not associated with increased postoperative side-effects or delayed recovery.

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Section: Discussionmentioning

confidence: 99%

The effect of magnesium sulphate infusion on the incidence and severity of emergence agitation in children undergoing adenotonsillectomy using sevoflurane anaesthesia

et al. 2013

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“…Concerning magnesium sulfate, its use is rather associated with the inhibition of ventilatory command. [16][17][18] Patients in group B received magnesium sulfate more frequently, but we still observed less hypercapnia among patients from this group. This observation may strengthen our findings on the impact of a maintenance dose of dexmedetomidine on the incidence of postoperative hypercapnia and delayed extubation.…”

Section: Primary End Point and Respiratory Complicationsmentioning

confidence: 50%

Comparison of Two Dexmedetomidine Administration Strategies on the Incidence of Postoperative Respiratory Complications: A Retrospective, Inverse Probability of Treatment Weighted Study

Baulier,

Popoff,

Wood

et al. 2023

The Journal of Clinical Pharma

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Randomized controlled trials have shown a higher risk of postoperative hypoxemia and delayed extubation with opioid free anesthesia (OFA), compared with opioid anesthesia. The practice of OFA is not standardized. The objective of this study is to investigate the association between dexmedetomidine administration protocol used and the occurrence of postoperative respiratory complications.This work is a retrospective, propensity score‐adjusted study (inverse probability of treatment weighting) conducted between January 2019 and September 2021 in a French tertiary care university hospital, and has included 180 adult patients undergoing major digestive surgery. Comparison of two anesthesia protocols: with a continuous intravenous maintenance dose of dexmedetomidine following a bolus (group B+M, n = 105) or with bolus dose alone (group B, n = 75). The main outcome measure was a composite respiratory endpoint within 24 hours of surgery.There was no significant difference in the incidence of overall respiratory complications as assessed by the primary endpoint. Nevertheless, there were more patients with postoperative hypercapnia in group B+M than in group B (16% vs. 2.5%, P = 0.004). Patients in group B+M were extubated later than patients in group B (40 minutes [20 to 74] versus 20 minutes [10 to 50], P = 0.004).Our study showed negative results for the primary endpoint. However, data on the increased risk of postoperative hypercapnia in patients receiving a maintenance dose of dexmedetomidine are new. Other prospective randomized studies with greater power are necessary to confirm these data and to make OFA safer, by reducing the prescribed doses of dexmedetomidine.This article is protected by copyright. All rights reserved

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“…For instance, MgSO 4 infusion (12 mg/kg/h) significantly reduced the requirement for halothane in dogs undergoing elective ovariohysterectomy in 1 study, 17 but a higher administration rate (15 mg/kg/h) failed to reduce the isoflurane requirement in dogs undergoing a similar surgical procedure 29 and did not change the MAC of isoflurane in goats. 30 Other studies in humans have reported that MgSO 4 infusion decreased desflurane requirements, 6,7 whereas it increased requirements for sevoflurane. 32 The study reported here had some potentially limiting factors that may have influenced the results.…”

Section: Discussionmentioning

confidence: 99%

“…The MAC of desflurane in humans was decreased by 24% following MgSO 4 infusion at a rate of 10 mg/kg/h. 7 In another study 6 that involved administration of the same dose of MgSO 4 to humans, desflurane requirements were decreased by 22%. In those studies, 6,7 the serum Mg concentrations of the patients were increased from baseline values by 75% and 68%, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5] A volatile anesthetic-sparing effect of MgSO 4 has been found for human patients anesthetized with desflurane. 6,7 Injectable anesthetic-and analgesic-sparing effects of MgSO 4 have been reported for several agents, including propofol, fentanyl, remifentanil, and midazolam. [8][9][10] Postoperative administration of MgSO 4 decreases opioid consumption and pain scores in a variety of human surgical patients.…”

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confidence: 99%

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Effects of magnesium sulfate and propofol on the minimum alveolar concentration preventing motor movement in sevoflurane-anesthetized dogs

Johnson¹,

Seddighi²,

Rohrbach³

et al. 2016

ajvr

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OBJECTIVE To evaluate the effect of MgSO4, alone and in combination with propofol, on the minimum alveolar concentration preventing motor movement (MACNM) in sevoflurane-anesthetized dogs. ANIMALS 6 healthy purpose-bred adult male Beagles (least squares mean ± SEM body weight, 12.0 ± 1.1 kg). PROCEDURES Dogs were anesthetized 3 times at weekly intervals. The MACNM was measured 45 minutes after induction of anesthesia (baseline; MACNM-B) and was determined each time by use of a noxious electrical stimulus. Treatments were administered as a loading dose and constant rate infusion (CRI) as follows: treatment 1, MgSO4 loading dose of 45 mg/kg and CRI of 15 mg/kg/h; treatment 2, propofol loading dose of 4 mg/kg and CRI of 9 mg/kg/h; and treatment 3, MgSO4 and propofol combination (same doses used previously for each drug). A mixed-model ANOVA and Tukey-Kramer tests were used to determine effects of each treatment on the percentage decrease from MACNM-B. Data were reported as least squares mean ± SEM values. RESULTS Decrease from MACNM-B was 3.4 ± 3.1%, 48.3 ± 3.1%, and 50.3 ± 3.1%, for treatments 1, 2, and 3, respectively. The decrease for treatments 2 and 3 was significantly different from that for treatment 1; however, no significant difference existed between results for treatments 2 and 3. CONCLUSIONS AND CLINICAL RELEVANCE MgSO4 did not affect MACNM, nor did it potentiate the effects of propofol on MACNM. Administration of MgSO4 in this study appeared to provide no clinical advantage as an anesthetic adjuvant.

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Analysis of the effect of perioperative magnesium sulphate on minimal alveolar concentration of desflurane using bispectral index monitoring

Cited by 4 publications

References 0 publications

The effect of magnesium sulphate infusion on the incidence and severity of emergence agitation in children undergoing adenotonsillectomy using sevoflurane anaesthesia

The effect of magnesium sulphate infusion on the incidence and severity of emergence agitation in children undergoing adenotonsillectomy using sevoflurane anaesthesia

Comparison of Two Dexmedetomidine Administration Strategies on the Incidence of Postoperative Respiratory Complications: A Retrospective, Inverse Probability of Treatment Weighted Study

Effects of magnesium sulfate and propofol on the minimum alveolar concentration preventing motor movement in sevoflurane-anesthetized dogs

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