Analysis of the EEG bispectrum, auditory evoked potentials and the EEG power spectrum during repeated transitions from consciousness to unconsciousness

Gajraj, R. J.; Doi, Matsuyuki; Mantzaridis, H.; Kenny, G. N. C.

doi:10.1093/bja/80.1.46

Cited by 161 publications

(74 citation statements)

References 40 publications

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“…Phase-amplitude coupling (PAC) belongs to the class of cross-spectral measures along with the bispectrum (Gajraj et al 1998), spectral cross-correlation, and cross-covariance. These measures enable analysis of interactions between oscillations in neural recordings.…”

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confidence: 99%

Phase-amplitude coupling, an indication of bursting in parkinsonism, is masked by periodic pulses

Sanders

2016

Journal of Neurophysiology

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Sanders TH. Phase-amplitude coupling, an indication of bursting in parkinsonism, is masked by periodic pulses. J Neurophysiol 115: 1587-1595, 2016. First published January 20, 2016 doi:10.1152/jn.00801.2015-Interactions between neural oscillations in the brain have been observed in many structures including the hippocampus, amygdala, motor cortex, and basal ganglia. In this study, one popular approach for quantifying oscillation interactions was considered: phase-amplitude coupling. The goals of the study were to use simulations to examine potential causes of elevated phase-amplitude coupling in parkinsonism, to compare simulated parkinsonian signals with recorded local field potentials from animal models of parkinsonism, to investigate possible relationships between increased bursting in parkinsonian single cells and elevated phase-amplitude coupling, and to uncover potential noise and artifact effects. First, a cell model that integrates incremental input currents and fires at realistic voltage thresholds was modified to allow control of stochastic parameters related to firing and burst rates. Next, the input currents and distribution of integration times were set to reproduce firing patterns consistent with those from parkinsonian subthalamic nucleus cells. Then, local field potentials were synthesized from the output of multiple simulated cells with varying degrees of synchronization and compared with subthalamic nucleus recordings from animal models of parkinsonism. The results showed that phase-amplitude coupling can provide important information about underlying neural activity. In particular, signals synthesized from synchronized bursting neurons showed increased oscillatory interactions similar to those observed in parkinsonian animals. Additionally, changes in bursting parameters such as the intraburst rate, the mean interburst period, and the amount of synchronization between neurons influenced the phase-amplitude coupling in predictable ways. Finally, simulation results revealed that small periodic signals can have a surprisingly large masking effect on phase-amplitude coupling.

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Phase-amplitude coupling, an indication of bursting in parkinsonism, is masked by periodic pulses

Sanders

2016

Journal of Neurophysiology

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“…In order to be a reliable and accurate method in the assessment of sedation, the range of BIS value at different sedation levels should not overlap, and should be independent of the drug used [14]. However, an overlap of BIS scores at distinct depths of anaesthesia have been observed elsewhere [15]. Also, BIS is not reliable with some hypnotic agents [16].…”

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confidence: 99%

A study to assess the value of bispectral analysis in intravenous sedation with midazolam during third molar surgery under local anaesthesia

et al. 2008

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SummaryThis study aimed to determine whether bispectral index (BIS) can be used as an indicator of sedation and recovery with intravenous midazolam. In Part A, 30 healthy patients undergoing third molar extraction under local anaesthesia were recruited. They were sedated with intravenous midazolam titrated to clinical endpoints. BIS values were recorded when adequately sedated (BIS S ) and when clinical recovery criteria were met (BIS R ). In Part B, another 30 patients were sedated to the range of BIS S obtained in Part A. Recovery was assessed postoperatively when the range of BIS R from Part A was reached. BIS titrated patients required less midazolam (p < 0.001). Seventy percent of Part B patients required increments of midazolam during surgery, compared to 16.7% in Part A (p < 0.001). Total dose of midazolam given was lower in Part B (p = 0.025). BIS is not effective as a sole indicator of endpoint in sedation with intravenous midazolam.

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“…7 Our data show that BIS values were lower during DES anesthesia than during FEN anesthesia. BIS values do not appear to be independent of the anesthetic agent administered, [10][11][12][13] therefore, comparable BIS values achieved with different agents may not represent the same depth of anesthesia. [11][12][13][14] The current BIS algorithm was derived from patients anesthetized with predominantly hypnotic drugs, such as propofol and inhaled anesthetics.…”

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Desflurane accelerates patient response during the wake-up test for scoliosis surgery

Ting

Teng

et al. 2004

Can J Anesth/J Can Anesth

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P Pu ur rp po os se e: : To evaluate if desflurane possesses a shorter wake-up onset time and less incidence of recall than fentanyl-based anesthesia.M Me et th ho od ds s: : Forty ASA class I-II adolescents, were enrolled into either a desflurane (DES) group, or a fentanyl (FEN) group for scoliosis surgery. Bispectral index (BIS) was monitored continuously in all patients throughout the procedure; the relationship between the wake-up time and BIS value was evaluated.R Re es su ul lt ts s: : Patients in the DES group had a significantly shorter wakeup onset than patients in the FEN group (4.1 ± 0.6 vs 8.9 ± 2.1 min, P < 0.01). No recall occurred during the wake-up test in the DES group, while five patients had recall in the FEN group, including two patients who recalled a given colour. Extubation time was significantly shorter in the DES group than in the FEN group (7.2 ± 0.6 vs 16 ± 11.9 min, P < 0.01).BIS values were significantly higher in the FEN group than in the DES group during anesthesia. (62 ± 4.5 vs 42 ± 5.3, P < 0.05) BIS after the wake-up test was similar in both groups (90 ± 2.9 vs 93.8 ± 2.5). There was a latency period (3.3 ± 1.2 min) between the maximal BIS value and wake-up time in the FEN group but not in the DES group. C Co on nc cl lu us si io on ns s: : DES provides a significantly shorter onset time during the wake-up test and a rapid emergence after scoliosis surgery. BIS monitoring during the wake-up test was more informative when anesthesia was maintained with DES compared to FEN infusion. 'avec le FEN (7,2 ± 0,6 vs 16 ± 11,9 min, P < 0,01). FEN qu'avec le DES (62 ± 4,5 vs 42 ± 5,3, P < 0,05). Après le test de réveil, le BIS était similaire dans les deux groupes (90 ± 2,9 vs 93,8 ± 2,5 Objectif : Vérifier si l'anesthésie avec du desflurane présente un réveil plus hâtif et moins d'incidence de souvenir que l'anesthésie avec du fentanyl. Méthode : Quarante adolescents d'état physique ASA I-II ont fait partie des groupes desflurane (DES) ou fentanyl (FEN) pour l'opéra-tion d'une scoliose. L'index bispectral (BIS) a été enregistré en continu chez tous les patients tout au long de l'intervention ; la relation entre le délai de réveil et la valeur du BIS a été évaluée. Résultats : Le retour à la conscience des patients du groupe DES a été significativement plus court que celui des patients du groupe FEN (4,1± 0,6 vs 8,9 ± 2,1 min, P < 0,01). Pendant le test de réveil, aucun patient du groupe DES n'a eu de souvenir, mais cinq patients du groupe FEN en ont eu, y compris deux patients qui ont pu nommer une couleur donnée. Le moment de l'extubation a été significativement plus tôt avec le DES qu Pendant l'anesthésie, les valeurs du BIS ont été plus élevées avec le

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Analysis of the EEG bispectrum, auditory evoked potentials and the EEG power spectrum during repeated transitions from consciousness to unconsciousness

Cited by 161 publications

References 40 publications

Phase-amplitude coupling, an indication of bursting in parkinsonism, is masked by periodic pulses

Phase-amplitude coupling, an indication of bursting in parkinsonism, is masked by periodic pulses

A study to assess the value of bispectral analysis in intravenous sedation with midazolam during third molar surgery under local anaesthesia

Desflurane accelerates patient response during the wake-up test for scoliosis surgery

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