Abstract:Muscle satellite cells are specific stem cells of skeletal muscle. They play important roles in muscle growth, hypertrophy, and regeneration. The transcriptional factor FOXO1, known to induce muscle atrophy, has been reported to be involved in muscle differentiation; however, the experiments have been performed using the immortalized cell line C2C12. In this study, we evaluated the differentiation capacity of satellite cells isolated from muscle‐specific FOXO1‐transgenic (Tg) mice because these cells are belie… Show more
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