Analysis of the different solubility data of cannabidiol in supercritical carbon dioxide described in the literature

Grijó, Daniel Ribeiro; Olivo, José Eduardo; Lima, Oswaldo Curty da Motta

doi:10.1007/s43153-021-00128-z

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…To assess the content of available CBD, samples were dried through a lyophilization step prior to extraction of the CBD in ethanol. Pure CBD shows a characteristic TGA weight-loss peak at 300 °C ( Figure 1 a) [ 25 ]. After drying, CBD-Silica shows 2 distinct weight-loss regions corresponding to desorption of propylamine groups at 220–320 °C (4.4 wt%) and phenyl groups at 500–700 °C (27.2 wt%), both from the organosilane matrix ( Figure 1 b).…”

Section: Resultsmentioning

confidence: 99%

Enhanced Skin Penetration of Cannabidiol Using Organosilane Particles as Transdermal Delivery Vehicles

et al. 2023

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There is potential for cannabidiol to act as an analgesic, anxiolytic and antipsychotic active ingredient; however, there is a need to find alternate administration routes to overcome its low oral bioavailability. In this work, we propose a new delivery vehicle based on encapsulation of cannabidiol within organosilica particles as drug delivery vehicles, which are subsequently incorporated within polyvinyl alcohol films. We investigated the long-term stability of the encapsulated cannabidiol, as well as its release rate, in a range of simulated fluids with different characterization techniques, including Fourier Transform Infrared (FT-IR) and High-performance Liquid Chromatography (HPLC). Finally, we determined the transdermal penetration in an ex vivo skin model. Our results show that cannabidiol is stable for up to 14 weeks within polyvinyl alcohol films at a range of temperatures and humidity. Release profiles are first-order, consistent with a mechanism involving diffusion of the cannabidiol (CBD) out of the silica matrix. The silica particles do not penetrate beyond the stratum corneum in the skin. However, cannabidiol penetration is enhanced and is detected in the lower epidermis, which was 0.41% of the total CBD in a PVA formulation compared with 0.27% for pure CBD. This is partly due to an improvement of its solubility profile as it is released from the silica particles, but we cannot rule out effects of the polyvinyl alcohol. Our design opens a route for new membrane technologies for cannabidiol and other cannabinoid products, where administration via non-oral or pulmonary routes can lead to better outcomes for patient cohorts in a range of therapeutics.

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Section: Resultsmentioning

confidence: 99%

Enhanced Skin Penetration of Cannabidiol Using Organosilane Particles as Transdermal Delivery Vehicles

et al. 2023

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Exploring the relationship between food-grade wax solubility in supercritical carbon dioxide and resulting hydrophobic development of impregnated paper substrates

Beheshtimaal

Hutton-Prager

2022

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Cannabis Extraction Technologies: Impact of Research and Value Addition in Latin America

et al. 2023

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The Cannabis genus of plants has been widely used in different cultures for various purposes. It is separated into three main species: sativa, indica, and ruderalis. In ancient practices, the plant was used as a multipurpose crop and valued for its fiber, food, and medicinal uses. Since methodologies for the extraction, processing, and identification of components have become available, medical, and food applications have been increasing, allowing potential development in the pharmaceutical and healthy functional food industries. Although the growing legalization and adoption of cannabis for the treatment of diseases are key factors pushing the growth of its market, the biggest challenge is to obtain higher-quality products in a time- and cost-effective fashion, making the process of extraction and separation an essential step. Latin American countries exhibit great knowledge of extraction technologies; nevertheless, it is still necessary to verify whether production costs are economically profitable. In addition, there has been an increase in commercial cannabis products that may or may not be allowed, with or without quality fact sheets, which can pose health risks. Hence, legalization is mandatory and urgent for the rest of Latin American countries. In this article, the phytochemical compounds (cannabinoids, terpenes, and phenolic compounds), the current status of legalization, extraction techniques, and research advances in cannabis in Latin America are reviewed.

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Analysis of the different solubility data of cannabidiol in supercritical carbon dioxide described in the literature

Cited by 3 publications

References 17 publications

Enhanced Skin Penetration of Cannabidiol Using Organosilane Particles as Transdermal Delivery Vehicles

Enhanced Skin Penetration of Cannabidiol Using Organosilane Particles as Transdermal Delivery Vehicles

Exploring the relationship between food-grade wax solubility in supercritical carbon dioxide and resulting hydrophobic development of impregnated paper substrates

Cannabis Extraction Technologies: Impact of Research and Value Addition in Latin America

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