Analysis of the correlation of gestational diabetes mellitus and peripheral ferritin with iron levels in early pregnancy

Guo, Wenchen; Wang, Hongyan; Qi, Lei; Yuan, Yuchao; Jing, Yanyan; Yang, Xia

doi:10.23736/s0391-1977.18.02734-7

Cited by 15 publications

(30 citation statements)

References 20 publications

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“…Another study had two different designs, so we extracted data as two individual studies. Therefore, 10 studies from eight articles were finally included in the meta‐analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Of the included studies, 1,040 pregnant women had GDM and 3,650 pregnant women were euglycemic. Three studies were cohort studies and seven studies were case–control studies.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Of the included studies, five were carried out in Western countries (USA n = 4, Denmark n = 1) and five studies were carried out in Asian countries (Iran n = 3, China n = 1, Lebanon n = 1). Seven studies used serum to measure the ferritin concentrations, and three studies used plasma to measure the ferritin concentrations. GDM was diagnosed based on several methods, as follows: three studies used World Health Organization screening criteria (75‐g oral glucose tolerance test), six studies used the Carpenter/Coustan diagnostic criteria, and one study used gynecology and obstetrics diagnostic criteria.…”

Section: Resultsmentioning

confidence: 99%

“…Seven studies used serum to measure the ferritin concentrations, and three studies used plasma to measure the ferritin concentrations. GDM was diagnosed based on several methods, as follows: three studies used World Health Organization screening criteria (75‐g oral glucose tolerance test), six studies used the Carpenter/Coustan diagnostic criteria, and one study used gynecology and obstetrics diagnostic criteria. Of the included studies, six studies determined the relationship between the ferritin concentration in the first trimester and GDM risk, and four studies determined the ferritin concentration in the second trimester.…”

Section: Resultsmentioning

confidence: 99%

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Association between the ferritin level and risk of gestational diabetes mellitus: A meta‐analysis of observational studies

Sun

Gao

et al. 2019

J of Diabetes Invest

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Aims/Introduction: The relationship between ferritin and the risk of gestational diabetes mellitus (GDM) has not been established. Thus, we carried out a meta-analysis based on the current literature. Materials and Methods:We searched relevant databases on Embase, PubMed, Cochrane Library and Web of Science before 10 May 2019 to determine the relationship between ferritin and the risk of GDM. The relative risks and 95% confidence intervals of GDM risk were summarized using a random effects model. Studies using categories of ferritin as exposure were combined by dose-response analysis. We carried out both linear and non-linear trends. We also carried out subgroup analysis, whether or not the studies adjusted for potential confounders, and meta-regression analysis to explore the source of heterogeneity. Sensitivity analysis was carried out to explore the robustness of the metaanalysis results. Results: A total of 10 studies involving 4,690 participants were identified. The summary relative risk comparing persons with the highest concentration categories of ferritin with the lowest concentration categories of ferritin was 1.87 (95% confidence interval 1.50-2.34; I 2 = 20.1%). Linear dose-response showed that an increase in ferritin of 10 lg/L increased the risk of GDM by 8% (1.08, 95% confidence interval 1.05-1.13, I 2 = 55.1%; n = 4). A nonlinear dose-response relationship also showed a consistently increasing risk of GDM with increased ferritin. No evidence of publication bias was detected. Conclusions: The findings from this meta-analysis suggest that increased ferritin levels are associated with an increased risk of GDM; however, we require further prospective cohort studies to confirm the results, especially the dose-response relationship between ferritin and GDM.

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“…Another study had two different designs, so we extracted data as two individual studies. Therefore, 10 studies from eight articles were finally included in the meta‐analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Of the included studies, 1,040 pregnant women had GDM and 3,650 pregnant women were euglycemic. Three studies were cohort studies and seven studies were case–control studies.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Association between the ferritin level and risk of gestational diabetes mellitus: A meta‐analysis of observational studies

Sun

Gao

et al. 2019

J of Diabetes Invest

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Ferritin and iron supplements in gestational diabetes mellitus: less or more?

Li,

Zhang,

2023

Eur J Nutr

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Immune Checkpoint-Blocking Nanocages Cross the Blood–Brain Barrier and Impede Brain Tumor Growth

Kim,

Yoon,

Lee

et al. 2023

ACS Biomater. Sci. Eng.

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Glioblastoma (GBM) is the deadliest tumor of the central nervous system, with a median survival of less than 15 months. Despite many trials, immune checkpoint-blocking (ICB) therapies using monoclonal antibodies against the PD-1/PD-L1 axis have demonstrated only limited benefits for GBM patients. Currently, the main hurdles in brain tumor therapy include limited drug delivery across the blood− brain barrier (BBB) and the profoundly immune-suppressive microenvironment of GBM. Thus, there is an urgent need for new therapeutics that can cross the BBB and target brain tumors to modulate the immune microenvironment. To this end, we developed an ICB strategy based on the BBB-permeable, 24-subunit human ferritin heavy chain, modifying the ferritin surface with 24 copies of PD-L1− blocking peptides to create ferritin-based ICB nanocages. The PD-L1pep ferritin nanocages first demonstrated their tumor-targeting and antitumor activities in an allograft colon cancer model. Next, we found that these PD-L1pep ferritin nanocages efficiently penetrated the BBB and targeted brain tumors through specific interactions with PD-L1, significantly inhibiting tumor growth in an orthotopic intracranial tumor model. The addition of PD-L1pep ferritin nanocages to triple in vitro cocultures of T cells, GBM cells, and glial cells significantly inhibited PD-1/PD-L1 interactions and restored T-cell activity. Collectively, these findings indicate that ferritin nanocages displaying PD-L1-blocking peptides can overcome the primary hurdle of brain tumor therapy and are, therefore, promising candidates for treating GBM.

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Analysis of the correlation of gestational diabetes mellitus and peripheral ferritin with iron levels in early pregnancy

Cited by 15 publications

References 20 publications

Association between the ferritin level and risk of gestational diabetes mellitus: A meta‐analysis of observational studies

Association between the ferritin level and risk of gestational diabetes mellitus: A meta‐analysis of observational studies

Ferritin and iron supplements in gestational diabetes mellitus: less or more?

Immune Checkpoint-Blocking Nanocages Cross the Blood–Brain Barrier and Impede Brain Tumor Growth

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