Analysis of the cochlear microphonic to a low-frequency tone embedded in filtered noise

Chertoff, Mark E.; Earl, Brian R.; Díaz, Francisco Javier Rodríguez; Sorensen, Janna L.

doi:10.1121/1.4757746

Cited by 26 publications

(28 citation statements)

References 33 publications

(35 reference statements)

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“…The response, however, is still dominated by basal hair cells near the electrode, which can confound an attempt to measure outer hair cell (OHC) health at the apex of the cochlea (Dallos, 1969; Patuzzi et al, 1989). To solve this problem, Chertoff et al (2012, 2014) implemented a filtered noise paradigm in which 733 & 762 Hz tone stimuli were embedded in high-pass filtered noise with seventeen consecutively increasing cutoff frequencies, allowing them to measure a cumulative response from seventeen corresponding regions along the length of the cochlear partition. Taking into account the electric field decay and geometric distance from each point of measurement to the electrode, they modeled a growth function of the CM amplitude as a function of distance along the length of the cochlear partition.…”

Section: Introductionmentioning

confidence: 99%

“…Taking into account the electric field decay and geometric distance from each point of measurement to the electrode, they modeled a growth function of the CM amplitude as a function of distance along the length of the cochlear partition. This growth function was deemed the cumulative amplitude function (CAF), and they showed that damage to OHCs will alter the growth of this function (Chertoff et al, 2012, 2014). …”

Section: Introductionmentioning

confidence: 99%

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The potential use of low-frequency tones to locate regions of outer hair cell loss

et al. 2016

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Current methods used to diagnose cochlear hearing loss are limited in their ability to determine the location and extent of anatomical damage to various cochlear structures. In previous experiments, we have used the electrical potential recorded at the round window –the cochlear response (CR) –to predict the location of damage to outer hair cells in the gerbil. In a follow-up experiment, we applied 10 mM ouabain to the round window niche to reduce neural activity in order to quantify the neural contribution to the CR. We concluded that a significant proportion of the CR to a 762 Hz tone originated from phase-locking activity of basal auditory nerve fibers, which could have contaminated our conclusions regarding outer hair cell health. However, at such high concentrations, ouabain may have also affected the responses from outer hair cells, exaggerating the effect we attributed to the auditory nerve. In this study, we lowered the concentration of ouabain to 1 mM and determined the physiologic effects on outer hair cells using distortion-product otoacoustic emissions. As well as quantifying the effects of 1 mM ouabain on the auditory nerve and outer hair cells, we attempted to reduce the neural contribution to the CR by using near-infrasonic stimulus frequencies of 45 and 85 Hz, and hypothesized that these low-frequency stimuli would generate a cumulative amplitude function (CAF) that could reflect damage to hair cells in the apex more accurately than the 762 stimuli. One hour after application of 1 mM ouabain, CR amplitudes significantly increased, but remained unchanged in the presence of high-pass filtered noise conditions, suggesting that basal auditory nerve fibers have a limited contribution to the CR at such low frequencies.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The potential use of low-frequency tones to locate regions of outer hair cell loss

et al. 2016

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“…Considering the origins of gross measurements can help interpret our finding of limited asymmetry. The electro-anatomy of the cochlear spiral generates a complex electric field, and a source does not simply propagate longitudinally toward a round window electrode (Chertoff et al, 2012). Responses from multiple origins with various phases, including those from outer hair cells, inner hair cells, the lateral wall, synapses, and auditory nerve fibers are summed vectorially in gross electrophysiologic measurements.…”

Section: A Harmonic Analysis Applied To Cochlear Responsesmentioning

confidence: 99%

An analysis of cochlear response harmonics: Contribution of neural excitation

Chertoff

Kamerer

Peppi

et al. 2015

The Journal of the Acoustical Society of America

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In this report an analysis of cochlear response harmonics is developed to derive a mathematical function to estimate the gross mechanics involved in the in vivo transfer of acoustic sound into neural excitation (f Tr ). In a simulation it is shown that the harmonic distortion from a nonlinear system can be used to estimate the nonlinearity, supporting the next phase of the experiment: Applying the harmonic analysis to physiologic measurements to derive estimates of the unknown, in vivo f Tr . From gerbil ears, estimates of f Tr were derived from cochlear response measurements made with an electrode at the round window niche from 85 Hz tone bursts. Estimates of f Tr before and after inducing auditory neuropathy-loss of auditory nerve responses with preserved hair cell responses from neurotoxic treatment with ouabain-showed that the neural excitation from low-frequency tones contributes to the magnitude of f Tr but not the sigmoidal, saturating, nonlinear morphology.

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“…Therefore, a tone burst without noise masking may not be place-specific, although it may be frequency-specific based on the frequency spectrum of the stimulus. Using high-pass noise, low-frequency place-specific CMs was in fact recorded in a study on humans (Ponton et al 1992) and supported by a study on animals (Chertoff et al 2012).…”

Section: Limitations For the Use Of Cmwsmentioning

confidence: 98%

Using a Concha Electrode to Measure Response Patterns Based on the Amplitudes of Cochlear Microphonic Waveforms Across Acoustic Frequencies in Normal-Hearing Subjects

Zhang

2015

Ear &Amp; Hearing

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We confirmed a measurable CMW response pattern using the concha electrode. We propose that the pattern's features may be partly due to variation along the cochlea of the activities and volume of hair cells and possibly also the physical properties of the basilar membrane. The clinical importance of these results may be related mainly to seven features of the CMW, including electrode locations, response patterns, inclusion of low frequencies, and uniqueness of CMWs (versus otoacoustic emissions, auditory brainstem responses, shorter stimulus, and audiograms). Limitations, such as signal to noise ratio, also exist. After further study, the concha electrode may be used in the clinic and in research, and the response pattern may be used to interpret the CMW measurement.

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Analysis of the cochlear microphonic to a low-frequency tone embedded in filtered noise

Cited by 26 publications

References 33 publications

The potential use of low-frequency tones to locate regions of outer hair cell loss

The potential use of low-frequency tones to locate regions of outer hair cell loss

An analysis of cochlear response harmonics: Contribution of neural excitation

Using a Concha Electrode to Measure Response Patterns Based on the Amplitudes of Cochlear Microphonic Waveforms Across Acoustic Frequencies in Normal-Hearing Subjects

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