Analysis of the cellular infiltrates and expression of cytokines in synovial tissue from patients with rheumatoid arthritis and reactive arthritis

Diagnostic classification of spondylarthropathy and rheumatoid arthritis by synovial histopathology: A prospective study in 154 consecutive patients

“…Whereas several groups of investigators previously identified diseaserelated synovial parameters in well-defined patients with full-blown and well-established disease (17)(18)(19)(20)(21)(22)(23)(24)(25)(26), the present study globally confirms these findings in an independent cohort of 67 patients fulfilling classification criteria.…”

“…Moreover, less specific synovial features probably lack direct diagnostic value when used as single parameters, but such features might be combined in multiparameter models to increase the predictive value in an individual patient. Such markers include the pattern and degree of vascularity, lining layer hyperplasia, and infiltration by T and B cells, as well as the presence of lymphoid aggregates, polymorphonuclear cells, and dendritic cells (21)(22)(23)(24)(25)(26).…”

Inflammation, Immune Reactivity, and Angiogenesis in a Severe Combined Immunodeficiency Model of Rheumatoid Arthritis

“…1,2 Recent evidence including the polyclonal nature of the CD4 ϩ T-cell infiltrate and the nearly uniform expression of activation molecules by these cells suggest they play a role in perpetuating chronic inflammation. 3 CD8 ϩ cells in the synovium seem to be both proinflammatory and regulatory, whereas CD20 ϩ B cells secreting immunoglobulins (Igs) are found in defined aggregates throughout the synovial tissue along with CD4 ϩ T cells and interdigitating dendritic cells.…”

“…3 CD8 ϩ cells in the synovium seem to be both proinflammatory and regulatory, whereas CD20 ϩ B cells secreting immunoglobulins (Igs) are found in defined aggregates throughout the synovial tissue along with CD4 ϩ T cells and interdigitating dendritic cells. 2 The local generation of immune complexes and activation of complement have been proposed as mechanisms contributing to tissue damage and propagation of inflammation. 3 Inflammatory cells in the RA joint consist primarily of polymorphonuclear leukocytes, monocytes, and macrophages.…”

“…3 Inflammatory cells in the RA joint consist primarily of polymorphonuclear leukocytes, monocytes, and macrophages. 1,2 Few polymorphonuclear leukocytes are localized in the RA synovium, although large numbers characteristically accumulate in the synovial fluid, presumably because of limited chemokine receptor expression. Numerous monocytes and macrophages are found within the RA synovial tissue and fluid.…”