Analysis of the canine <i>EDAR</i> gene and exclusion as a candidate for the hairless phenotype in the Chinese Crested dog

Sander, Petra; Drögemüller, Cord; Cadieu, Édouard; André, Catherine; Leeb, Tosso

doi:10.1111/j.1365-2052.2005.01242.x

Cited by 2 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the phenotype has some similarities to anhidrotic ectodermal dysplasia, the distribution of alopecia is different as is the histopathological picture. Hence, it is unlikely that the ED1 gene is responsible for the hairless phenotype in the Chinese crested dog, as has recently been confirmed by linkage analysis 94 …”

mentioning

confidence: 87%

“…Hence, it is unlikely that the ED1 gene is responsible for the hairless phenotype in the Chinese crested dog, as has recently been confirmed by linkage analysis. 94 Peruvian hairless dog, and Peruvian Inca Orchid The Peruvian hairless dog and the Peruvian Inca Orchid dog (also known as Inca hairless dog) are distinct but very rare breeds. They resemble the Mexican hairless and Chinese crested dog in that hairlessness is caused by an autosomal dominant trait that produces normally haired and hairless littermates.…”

Section: Aplasia Of Hair Follicles With Dental Dysplasia (Analogous Tmentioning

confidence: 99%

See 1 more Smart Citation

An overview on congenital alopecia in domestic animals

Mecklenburg¹

2006

Veterinary Dermatology

View full text Add to dashboard Cite

Alopecia, that is, lack of hair in any quantity, is a frequent complaint of pet owners. Although mostly acquired, rare congenital forms of alopecia exist that are associated with abnormalities in hair follicle morphogenesis. Congenital alopecias can result in changes in quality or quantity of hair follicles and the hair fibres produced by them. They vary in terms of clinical presentation and mode of inheritance. Histopathology is usually needed in order to differentiate between a reduced number of otherwise normal hair follicles and qualitative hair follicle abnormalities. Although our understanding of the molecular mechanisms that drive hair follicle morphogenesis in mice and humans has significantly increased during the last decade, still very little is known about congenital alopecias in domestic animals. Because of their rarity and the general lack of knowledge about their pathophysiology, classification of congenital alopecias in domestic animals is still unsatisfactory. This article reviews hair follicle morphogenesis and its most important molecular mechanisms, and it discusses the various forms of congenital alopecia occurring in domestic animals that have been described in the literature, differentiating between hair follicle aplasia, hair follicle dysplasia (i.e. defects associated with hair follicle development and defects associated with hair shaft formation), and neuroectodermal dysplasias, the latter involving the hair follicle pigmentary system.

show abstract

mentioning

confidence: 87%

Section: Aplasia Of Hair Follicles With Dental Dysplasia (Analogous Tmentioning

confidence: 99%

An overview on congenital alopecia in domestic animals

Mecklenburg¹

2006

Veterinary Dermatology

View full text Add to dashboard Cite

show abstract

“…Inherited as a single gene semi-dominant trait, the CED locus was initially mapped to canine chromosome 17 using microsatellites in 2005 [33]. After excluding candidate genes such as ectodysplasin A1 receptor (EDAR) [33,34], a GWAS and additional fine mapping showed that CED was due to a mutation in the forkhead box transcription factor (FOXI3) [35]. This gene, which is a member of a large transcription factor family, is specifically expressed in developing hair and teeth, and is a regulator of ectodermal development [32], making it a superb candidate for the trait [35].…”

Section: (A) Chinese Crested Xolo and Peruvian Hairless Breedsmentioning

confidence: 99%

The bald and the beautiful: hairlessness in domestic dog breeds

Parker¹,

Harris²,

Dreger³

et al. 2017

Phil. Trans. R. Soc. B

View full text Add to dashboard Cite

An extraordinary amount of genomic variation is contained within the chromosomes of domestic dogs, manifesting as dramatic differences in morphology, behaviour and disease susceptibility. Morphology, in particular, has been a topic of enormous interest as biologists struggle to understand the small window of dog domestication from wolves, and the division of dogs into pure breeding, closed populations termed breeds. Many traits related to morphology, including body size, leg length and skull shape, have been under selection as part of the standard descriptions for the nearly 400 breeds recognized worldwide. Just as important, however, are the minor traits that have undergone selection by fanciers and breeders to define dogs of a particular appearance, such as tail length, ear position, back arch and variation in fur (pelage) growth patterns. In this paper, we both review and present new data for traits associated with pelage including fur length, curl, growth, shedding and even the presence or absence of fur. Finally, we report the discovery of a new gene associated with the absence of coat in the American Hairless Terrier breed.This article is part of the themed issue ‘Evo-devo in the genomics era, and the origins of morphological diversity’.

show abstract

Analysis of the canine EDAR gene and exclusion as a candidate for the hairless phenotype in the Chinese Crested dog

Cited by 2 publications

References 11 publications

An overview on congenital alopecia in domestic animals

An overview on congenital alopecia in domestic animals

The bald and the beautiful: hairlessness in domestic dog breeds

Contact Info

Product

Resources

About