Analysis of the Biomechanical Effects of Spinal Fusion to Adjacent Vertebral Segments of the Lumbar Spine using Multi Body Simulation

Bauer, Sabine; Paulus, Dietrich

doi:10.5013/ijssst.a.15.02.01

Cited by 4 publications

(4 citation statements)

References 10 publications

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“…Surgical interventions always represent a major intervention in the natural biomechanics of the musculoskeletal system. Thus, several studies on the effects of spinal fusion can be found in the literature [29,71,119]. The resulting kinematic effects of spinal fusion were investigated by Ignasiak et al, who proposed a method for the prediction of a full-body sagittal alignment including reciprocal changes as a reaction to spinal fusion [68].…”

Section: Studies With Biomechanical or Clinical Focusmentioning

confidence: 99%

Multibody Models of the Thoracolumbar Spine: A Review on Applications, Limitations, and Challenges

et al. 2023

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Numerical models of the musculoskeletal system as investigative tools are an integral part of biomechanical and clinical research. While finite element modeling is primarily suitable for the examination of deformation states and internal stresses in flexible bodies, multibody modeling is based on the assumption of rigid bodies, that are connected via joints and flexible elements. This simplification allows the consideration of biomechanical systems from a holistic perspective and thus takes into account multiple influencing factors of mechanical loads. Being the source of major health issues worldwide, the human spine is subject to a variety of studies using these models to investigate and understand healthy and pathological biomechanics of the upper body. In this review, we summarize the current state-of-the-art literature on multibody models of the thoracolumbar spine and identify limitations and challenges related to current modeling approaches.

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Section: Studies With Biomechanical or Clinical Focusmentioning

confidence: 99%

Multibody Models of the Thoracolumbar Spine: A Review on Applications, Limitations, and Challenges

et al. 2023

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“…Studies conducted have shown the accelerated development of adjacent segment disease and disc degeneration in the areas adjacent to the spinal fusion. 18 There are also the risk factors that come from any major surgery such as infection and damage to spinal nerves and tissue surrounding the area. These numerous risks have led researchers to explore less invasive treatments.…”

Section: Intervertebral Discmentioning

confidence: 99%

Development and Characterization of a AuNP-Genipin-Viscoelastic Collagen Material

Bradley

Grant

et al. 2023

J Biomater Appl

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Lower back pain is one of the leading causes of disability, affecting 11.9% of the population worldwide and studies have shown that intervertebral disc degeneration is a common cause for chronic lower back pain. We have explored the combination of three components, viscoelastic collagen, genipin, and gold nanoparticles to determine its potential to promote regeneration of the intervertebral disc, specifically for nucleus pulposus regeneration. The goal of this study was to develop, fabricate and characterize different formulations of viscoelastic collagen conjugated with gold nanoparticles and genipin to assess the feasibility as a tissue template. Results demonstrated the successful attachment of gold nanoparticles to the viscoelastic collagen utilizing the genipin crosslinker. For each of the viscoelastic collagen compositions examined, cell biocompatibility was achieved. The results also demonstrated an increase in stiffness of the material with different sizes and concentrations of AuNPs. Results from the TEM and STEM also demonstrated that the viscoelastic collagen that was developed did not display the characteristic D banding pattern of polymerized collagen. The findings from this study could lead to the development of a more efficient and cost-effective treatment for patients with chronic back pain caused by IVD degeneration.

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“…Computer simulations of spinal mechanics can provide information that helps to answer medical research questions and might become an important asset in planning surgical interventions. Recent advances in multibody simulation allow for the modelling of patient-specific spinal structures, including the simulation of complex motion sequences [4][5][6]. Typically, parameters like stiffness and damping of the modelled bodies are taken from studies performed on real tissue [48,61] and additional aspects can be taken into account, such as image-based tissue degeneration scores [30,62].…”

Section: Medical and Simulation Backgroundmentioning

confidence: 99%

Visualization of Human Spine Biomechanics for Spinal Surgery

Eulzer,

Bauer,

Kilian

et al. 2020

Preprint

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Fig. 1. Overview of exploration techniques for a spinal disc deformation simulation. We extract patient movement as an animation (left), which we connect with detailed simulation results (middle), including force impact directions. Each value-over-time plot is associated with the corresponding spinal disc using patient-specific anatomy. A simplified depiction allows for at-a-glance assessments and ensemble comparisons (right).

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Analysis of the Biomechanical Effects of Spinal Fusion to Adjacent Vertebral Segments of the Lumbar Spine using Multi Body Simulation

Cited by 4 publications

References 10 publications

Multibody Models of the Thoracolumbar Spine: A Review on Applications, Limitations, and Challenges

Multibody Models of the Thoracolumbar Spine: A Review on Applications, Limitations, and Challenges

Development and Characterization of a AuNP-Genipin-Viscoelastic Collagen Material

Visualization of Human Spine Biomechanics for Spinal Surgery

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