Analysis of the association between the severity of ocular and systemic pain

Yamanishi, Ryutaro; Uchino, Makoto; Kawashima, Motoko; Doğru, Murat; Matsuguma, Shinichiro; Ohta, Michio

doi:10.1016/j.jtos.2019.05.008

Cited by 8 publications

(9 citation statements)

References 30 publications

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“…Moreover, it was previously reported that dwelling areas was an important determinant of patients in seeking and receiving care for TB [39]. Similarly in a previous study, a TB treatment history was a risk factor for DD [24]. TB can result in chronic lung injury, with anti-TB treatments confirmed as a highrisk factor for pulmonary function deterioration [40].…”

Section: Discussionmentioning

confidence: 64%

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Association between diagnostic delay and prognosis of pulmonary tuberculosis in Shandong, China: a retrospective study

et al. 2022

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Background Tuberculosis (TB) is one of the main infectious diseases that seriously threatens global health, while diagnostic delay (DD) and treatment dramatically threaten TB control. Methods Between 2005 and 2017 in Shandong, China, we enrolled pulmonary tuberculosis (PTB) patients with DD. DD trends were evaluated by Joinpoint regression, and associations between PTB patient characteristics and DD were estimated by univariate and multivariate logistic regression. The influence of DD duration on prognosis and sputum smear results were assessed by Spearman correlation coefficients. Results We identified 208,822 PTB cases with a median DD of 33 days (interquartile range (IQR) 18–63). The trend of PTB with DD declined significantly between 2009 and 2017 (annual percent change (APC): − 4.0%, P = 0.047, 2009–2013; APC: − 6.6%, P = 0.001, 2013–2017). Patients aged > 45 years old (adjusted odds ratio (aOR): 1.223, 95% confidence interval (CI) 1.189–1.257, 46–65 years; aOR: 1.306, 95% CI 1.267–1.346, > 65 years), farmers (aOR: 1.520, 95% CI 1.447–1.596), and those with a previous treatment history (aOR: 1.759, 95% CI 1.699–1.821) were prone to developing long DD (> 30 days, P < 0.05). An unfavorable outcome was negatively associated with a short DD (OR: 0.876, 95% CI 0.843–0.910, P < 0.001). Sputum smear positive rate and unfavorable outcomes were positively correlated with DD duration (Spearman correlation coefficients (rs) = 1, P < 0.001). Conclusions The DD situation remains serious; more efficient and comprehensive strategies are urgently required to minimize DD, especially for high-risk patients.

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Section: Discussionmentioning

confidence: 64%

“…Spearman correlation coefficients (rs) ranged from − 1 to + 1. A rs < 0 or > 0 revealed positive or negative relations, respectively, while rs = 0 indicated no significant correlation between two variables [24].…”

Section: Discussionmentioning

confidence: 92%

Association between diagnostic delay and prognosis of pulmonary tuberculosis in Shandong, China: a retrospective study

et al. 2022

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“…Studies have attempted to quantify subjective eye discomfort in dry eye disease. However, such discomfort is affected by conditions including ocular surface diseases 16 , inflammation 17 , neuropathic factors 18 , and nonocular discomfort 19 . The purely mechanical stress encountered by patients with ocular FBs differs from the multifactorial dry eye disease.…”

Section: Discussionmentioning

confidence: 99%

Eye irrigation as a first-line treatment and diagnostic method for emergency department patients who complain of ocular foreign bodies

Chou

Chen

Kang

et al. 2021

Sci Rep

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This prospective study aimed at determine whether eye irrigation removes ocular foreign bodies (FBs) and whether ocular pain predicts FBs. Emergency department patients complaining of ocular FBs were enrolled. In the irrigation group (n = 52), pain was evaluated with a visual analog scale before and after irrigation, and the presence of FBs was determined under a slit-lamp. In the nonirrigation group (n = 27), the evaluations were performed upon arrival. The corneal FB retention rate was found significantly lower in the irrigation (13/52, 25%) than in the nonirrigation groups (13/27, 48%; P = 0.04). After irrigation, those without FBs had more patients experiencing pain reduction (67%) compared to those with retained FBs (46%; P = 0.14) and had a greater magnitude of change in pain score (mean ± SD, − 2.6 ± 2.7 vs. − 0.7 ± 1.4; P = 0.02). An improvement in ocular pain score ≥ 5 points after irrigation predicted the absence of FBs with a negative predictive value of 100%. Eye irrigation significantly lowered corneal FB retention; if ocular pain decreased considerably, the probability of retained FBs was low, making irrigation-associated pain score reduction a feasible diagnostic method to exclude FB retention without needing specialized ophthalmic examinations.

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“…3 Others have found greater discordance between symptoms and signs or greater ocular pain among patients with conditions associated with nonocular pain; however, mean ocular discomfort scores were similar in the patients of DREAM study for those with or without self-reported rheumatoid arthritis, osteoarthritis, and fibromyalgia (Table 2). [14][15][16][17] Because the eligibility criteria for the DREAM clinical trial specified thresholds for signs and a restricted range for the baseline OSDI symptom score (23-80), the DREAM study population was not well suited for exploration of patients with highly discordant symptoms and signs.…”

Section: Discussionmentioning

confidence: 99%

Ocular Discomfort and Quality of Life Among Patients in the Dry Eye Assessment and Management Study

Sayegh

Farrar

et al. 2020

Cornea

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To assess the association of severity of ocular discomfort with measures of quality of life among patients with moderate to severe dry eye disease (DED).Methods: This is a prospective, observational, cohort study within a randomized clinical trial. Patients (N = 535) in the Dry Eye Assessment and Management study with moderate to severe DED completed the Ocular Surface Disease Index on DED symptoms, the SF-36 on quality of life, and the Brief Ocular Discomfort Inventory questionnaire and had a comprehensive ophthalmic assessment by a study-certified clinician. The ocular discomfort on average over the past week was scored on an 11-point scale (0 for no discomfort and 10 for discomfort as bad as you can imagine). Results:The average ocular discomfort scores for patients ranged from 0 to 10, with a mean of 4.28. Discomfort scores did not vary with demographic characteristics, signs of DED, self-reported depression, or self-reported nonocular pain conditions. Ocular discomfort scores did correlate moderately to strongly with total Ocular Surface Disease Index scores (Spearman correlation coefficient, r s , 0.47-0.67) and with measures of interference with activities of daily living [general activity level, mood, walking ability, ability for normal work, relations with other people, sleep, and enjoyment of life (r s = 0.39-0.65)].Conclusions: Among patients in the Dry Eye Assessment and Management study, worse ocular discomfort was associated with worse overall DED symptoms and interfered to a greater degree with activities of daily living. Ocular discomfort is an important part of the assessment of patients with DED.

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Analysis of the association between the severity of ocular and systemic pain

Cited by 8 publications

References 30 publications

Association between diagnostic delay and prognosis of pulmonary tuberculosis in Shandong, China: a retrospective study

Association between diagnostic delay and prognosis of pulmonary tuberculosis in Shandong, China: a retrospective study

Eye irrigation as a first-line treatment and diagnostic method for emergency department patients who complain of ocular foreign bodies

Ocular Discomfort and Quality of Life Among Patients in the Dry Eye Assessment and Management Study

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