Analysis of the association between interleukin -1β (+3954) gene polymorphism and chronic periodontitis in a sample of the south Indian population

Polymorphic Regions in the Interleukin-1 Gene and Susceptibility to Chronic Periodontitis: A Genetic Association Study

“…The findings of this study are in agreement with the above-mentioned studies. In contrast, a previous study by Kaarthikeyan et al (2009), reported a lack of association between the SNP at + 3954 in the IL1B gene and chronic periodontitis susceptibility in a similar population. The observed difference in the results may be attributed to the small sample size used in the study by Kaarthikeyan et al (2009), which may not have been adequate to detect the difference in genotypic or allelic variation between the groups.…”

“…Previous studies in an Indian population have given conflicting results with a few studies showing a positive association (Shete et al, 2010;Archana et al, 2012), and one study showing no association between SNP at + 3954 in the IL1B gene and chronic periodontitis (Kaarthikeyan et al, 2009).…”

Association of Periodontal Disease and Pre-term Low Birth Weight Infants

“…Although the presence of gram-negative bacteria is essential in initiating the periodontal destruction, several environmental and genetic factors contribute to the individual variation in the course of the disease. Some of the bacteria involved in this like Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans have the ability to invade cells and tissues [6]. Thus, the exposure of the body to these organisms generates an inflammatory response at the systemic level which may cause potential damage to certain organs.…”

Single nucleotide polymorphisms at interleukin (IL)-1β + 3954 and vitamin D receptor (VDR) TaqI in chronic periodontitis patients: A pilot study in North Indian population

“…[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] However, there are very few reports concerning the association of IL-1 gene polymorphism with chronic periodontitis in Indian population and particularly no documentation for VDR polymorphisms. [26][27][28][29] Thus, the aim of the present endeavor was to study the association of two SNPs IL-1β + 3954 (rs1143634) and VDR TaqI (rs731236) with chronic periodontitis in a sample of North Indian population.…”