Analysis of the Association between the <i>Tgfb1</i> Gene Haplotype and Liver Diseases in Children
Rivada M. Kurabekova,
Olga E. Gichkun,
Olga M. Tsirulnikova
et al.
Abstract:Transforming growth factor-1 (TGF-1), a cytokine with immunosuppressive and pro-fibrogenic activity, is a potential marker of infection, liver transplant rejection, and fibrosis. Its levels in the blood and tissues depend on many factors; however, the role of gene polymorphism is still unclear. In this work, the distribution frequency of three single nucleotide polymorphism (SNP) variants of the Tgfb1 gene, namely rs1800469, rs1800470, and rs1800471, was studied in children with end-stage liver disease (ESLD).… Show more
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