Analysis of the anxiolytic-like effect of TRH and the response of amygdalar TRHergic neurons in anxiety

Thyrotropin-releasing hormone as a treatment for cancer-related fatigue: a randomized controlled study

“…Because of these exclusion criteria, we confirmed that the anti-fatigue effects of TRH were not related to improvement in these other symptoms. In previous studies, TRH has been demonstrated to produce antidepressant effects [19], and, in a more limited number of reports, reduction in symptoms of anxiety as well [38,39]. In the present study, we did observe significant improvement in symptoms of sleep disturbance, as assessed by the LSEQ in the weeks following TRH administration.…”

The PKC and ERK/MAPK Pathways Regulate Glucocorticoid Action on TRH Transcription

“…In vivo, stress increases BDNF expression in the PVN in a fast and transient manner [64], which could activate TRH neurons expressing TrkB receptor [63]. One could envisage situations where the TRHergic neuron receives diverse stimuli [65,66], simultaneously or in succession, adjusting the levels of immediate early genes expression, differentially modulating transcription factors as CREB, GR of AP-1 affecting thus, the inhibitory effect of rising corticosterone levels and, depending on the type of stress or previous history of the animal, alter the response to an incoming stimulus.…”

Immunohistochemical localization of thyrotropin-releasing hormone in the brain of reptiles

“…More extensive is the distribution in rat, in which TRHir cells are situated in the diagonal band of Broca, amygdaloid complex, bed nucleus of the stria terminalis and basal ganglia (Lechan et al, 1986;Tsuruo et al, 1987;Merchenthaler et al, 1988;Heuer et al, 2000). In addition, TRH neurons of the amygdala in rats have been recently demonstrated to be involved in the reduction of anxiety (Gutié rrez-Mariscal et al, 2008).…”