Analysis of the antimalarial, mefloquine, in blood and plasma using high-performance liquid chromatography

Kapetanović, Izet M.; DiGiovanni, J.D.; Bartosevich, J. F.; Meléndez, Víctor; Bredow, J. von; Heiffer, Melvin H.

doi:10.1016/s0378-4347(00)84838-0

Cited by 28 publications

(3 citation statements)

References 10 publications

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“…Recovery of M from plasma, in the concentration range of 150-3000 ng ml-', was between 91 and 99%; recovery of the metabolite, in the range of 500-2000 ng ml-', was between 62 and 69%. No interference from other antimalarial drugs was expected (Kapetanovic et al, 1983), The intraassay coefficient of variation was less than 5%.…”

Section: Collection Of Samplesmentioning

confidence: 85%

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Divided‐dose kinetics of mefloquine in man.

Franssen

Rouveix

Lebras

et al. 1989

Brit J Clinical Pharma

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The kinetics of mefloquine was investigated following oral divided-doses in 10 healthy Caucasian volunteers. They received 500 or 750 mg followed by 500 mg 8 h later. Unchanged mefloquine (M) and its carboxylic acid metabolite (MM) were measured in whole blood and plasma for 50 days by h.p.l.c. Maximum blood and plasma M concentrations of 1872 ± 362 ng ml-' (mean ± s.d.) and 1900 ± 434 ng ml-', respectively, were found within 6-10 h after the second dose. The terminal plasma elimination half-life was 20.1 ± 3.7 days (mean ± s.d.) and the oral clearance was 22.3 ± 6.7 ml h-1 kg-1 (mean ± s.d.). Plasma concentrations of MM exceeded those of M by 2-3 fold within 2 days. The whole blood concentration of MM was lower than that in plasma but also exceeded the whole blood concentration of M.

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Section: Collection Of Samplesmentioning

confidence: 85%

“…after liquid-liquid extraction. Since Kapetanovic et al (1983) have reported that M is unstable in the isopropylacetate used for the simultaneous extraction of the drug and its main metabolite, M was extracted with dichloromethane, in which it is stable, and a second extraction was carried out with ethylacetate to measure MM.…”

Section: Collection Of Samplesmentioning

confidence: 99%

Divided‐dose kinetics of mefloquine in man.

Franssen

Rouveix

Lebras

et al. 1989

Brit J Clinical Pharma

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“…A two-step extraction procedure was developed which provided clean samples, essential for sensitive detection at 222 nm. The apparent maximum absorbance for MQ is 222 nm (Kapetanovic et al, 1983) and sufficient sensitivity was achieved at this wavelength to detect both MQ and the I.S. The extraction solvent, hexaneethyl acetate (9:1) gave optimal recovery of mefloquine and I.S.…”

Section: Discussionmentioning

confidence: 99%

The pharmacokinetics of mefloquine in man: lack of effect of mefloquine on antipyrine metabolism.

Riviere¹,

Back²,

Breckenridge³

et al. 1985

Brit J Clinical Pharma

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1 A method is described for the determination of the new antimalarial agent, mefloquine, in plasma and urine. 2 After oral administration of 750 mg mefloquine to six volunteers, absorption was apparently slow, with plasma mefloquine concentrations at 24 h (559 + 181 ng ml-1; mean + s.d.) higher than at 6 h (459 + 166 ng ml-1). The elimination half-life was 373 + 249 h, oral clearance was 5.09 + 2.71 h-1, and apparent volume of distribution was 35.7 ± 30.71 kg-1 (assuming 100% bioavailability). 3 Mefloquine (750 mg) had no significant effect on salivary kinetics of antipyrine or on the metabolic clearance of antipyrine to its three main metabolites, 3-hydroxymethylantipyrine, 4-hydroxyantipyrine and norantipyrine, when antipyrine was administered either 2 h or 2 weeks after dosing with mefloquine.

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The Use of High Performance Liquid Chromatography in Human Toxicology

Osselton¹

1986

Analytical Methods in Human Toxicology

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Analysis of the antimalarial, mefloquine, in blood and plasma using high-performance liquid chromatography

Cited by 28 publications

References 10 publications

Divided‐dose kinetics of mefloquine in man.

Divided‐dose kinetics of mefloquine in man.

The pharmacokinetics of mefloquine in man: lack of effect of mefloquine on antipyrine metabolism.

The Use of High Performance Liquid Chromatography in Human Toxicology

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