Analysis of the anti-inflammatory properties of Rosmarinus officinalis L. in mice

Benincá, Jucélia Pizzetti; Dalmarco, Juliana Bastos; Pizzolatti, Moacir Geraldo; Fröde, Tânia Sílvia

doi:10.1016/j.foodchem.2010.06.056

Cited by 81 publications

(53 citation statements)

References 28 publications

(40 reference statements)

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“…Rosemary essential oil and extract were found to significantly inhibit leukocyte migration in vivo [41]. This reduced the number of leukocytes (White Blood Cells) at the site of inflammation, resulting in an anti-inflammatory response [42,43]. Rosemary extract also inhibited other proinflammatory substances, such as nitric oxide and inflammationassociated genes [42][43][44].…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

Rosmarinus Officinalis (Rosemary): A Novel Therapeutic Agent for Antioxidant, Antimicrobial, Anticancer,Antidiabetic, Antidepressant, Neuroprotective, Anti-Inflammatory, and Anti-Obesity Treatment

Hamidpour¹,

Hamidpour²,

Elias³

2017

BJSTR

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Section: Anti-inflammatory Activitymentioning

confidence: 99%

Rosmarinus Officinalis (Rosemary): A Novel Therapeutic Agent for Antioxidant, Antimicrobial, Anticancer,Antidiabetic, Antidepressant, Neuroprotective, Anti-Inflammatory, and Anti-Obesity Treatment

Hamidpour¹,

Hamidpour²,

Elias³

2017

BJSTR

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“…No injection volume ever exceeded 100 ml. The doses of carnosol used here were based on the study of Beninca et al (2011) demonstrating the anti-inflammatory effects of carnosol at doses to mice of 2.5-10 mg/kg. Similarly, the dose of CYP was selected based on a study (Farsam et al, 2011).…”

Section: Experimental Tumor Modelmentioning

confidence: 99%

“…Widely used as a source of anti-oxidants in the food industry (Aruoma et al, 1992;Beninca et al, 2011;Nissen et al, 2000;Sotelo-Felix et al, 2002), this anti-oxidant activity is attributed to several polyphenolic constituents including carnosol and carnosic acid (Johnson et al, 2010;Sotelo-Felix et al, 2002). Carnosol, an o-diphenolic diterpene first isolated from sage (Gajhede et al, 1990), is generated by oxidative degradation of carnosic acid (Johnson, 2011, Munne-Bosch et al, 1999.…”

Section: Introductionmentioning

confidence: 99%

“…In the Johnson et al (2010) study, the anti-inflammatory effects of carnosol were documented as reductions in the formation of nitric oxide (NO) and proinflammatory leukotrienes. In addition to these effects, carnosol has been shown to inhibit 5-lipoxygenase and cyclooxygenase-2 activity, reduce expression of adhesion molecules (ICAM-1), and activate NF-B during inflammation (Altinier et al, 2007;Beninca et al, 2011;Lo et al, 2002;Poeckel et al, 2008;Ya-Mei Yu et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of anti-cancer and immunomodulatory effects of carnosol in a Balb/c WEHI-164 fibrosarcoma model

Rahnama

Mahmoudi

Rabe

et al. 2014

Journal of Immunotoxicology

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Agents that destroy tumor cells and simultaneously boost host anti-tumor immunity are of keen interest in cancer therapy. In the present study, the effect of carnosol on anti-tumor immunity in a Balb/c mouse model of fibrosarcoma was evaluated. Carnosol was administered intraperitoneally daily (at 5 or 10 mg/kg/day, for 7 days) to tumor-bearing mice (i.e. 7 days after initial injection of tumor cells). Another group of tumor-bearing mice was treated with 20 mg cyclophosphamide/kg/d (positive control); a final group received vehicle only (vehicle control). After an initial measure on Day 0, tumor size was measured twice during the 7-day treatment period. One day after the final treatment with vehicle/carnosol (i.e. Day 7), the mice had their tumors measured and then were euthanized to permit their spleen and tumor to be harvested for isolation of, respectively, splenocytes and tumor-associated lymphocytes. Using these materials, spontaneous and mitogen-induced release of interleukin (IL)-4, IL-10, and interferon (IFN)-, lymphocyte proliferation, and the absolute numbers/relative percentages of splenic and tumor-associated T-regulatory (T reg ) and other T-lymphocyte sub-sets were evaluated. The results showed that carnosol at both doses significantly suppressed tumor growth and caused depletion of splenic and tumor-associated T reg cells. It also caused relative (vs control mouse cell values) decreases in splenocyte spontaneous/inducible production of IL-4 and IL-10 and increases in IFN and cell proliferation. Carnosol at either dose did not cause changes in the percentages of CD4 + or CD8 + lymphocytes in the spleen or in tumor-associated lymphocyte populations. The observed increases in IFN, decreases in IL-10 and IL-4 production, and reductions in splenic/tumor-associated T reg cell levels might be signs reflecting the potential anti-tumor activity of carnosol. Based on the findings here, it is asserted that carnosol is a likely candidate -after more complete toxicologic evaluation -for eventual use as an anti-cancer therapeutic.

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“…Its use since ancient times in traditional medicine is justiied by its antiseptic [1,2], antirheumatic [3], anti-inlammatory, antispasmodic [4,5], antimicrobial, and anti-hepatotoxic properties [6]. Its appreciation as a spice for seasoning and food preservation [7] is supported by a very high antioxidant activity [8].…”

Section: Introductionmentioning

confidence: 99%

Phytochemistry, Antioxidant, Antibacterial Activity, and Medicinal Uses of Aromatic (Medicinal Plant Rosmarinus officinalis)

Hameed¹,

Mohammed²

2017

Aromatic and Medicinal Plants - Back to Nature

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Rosemary is a well-known aromatic and medicinal plant whose consumption serves to remedy the number of disorders. Its essential oil (EO) constitutes an important ingredient for well-being feeling improvement through beauty products such as soaps, perfumes, and deodorants. The identiication of phytochemical compounds is based on the peak area, retention time molecular weight, molecular formula, chemical structure, and pharmacological actions. It contains chemical constitutions, which may be useful for various herbal formulations as anti-inlammatory, analgesic, antipyretic, cardiac tonic, and antiasthmatic. Therefore, this chapter reviews the phytochemical compounds of Rosmarinus oicinalis, using methanolic extraction. The phytochemical compound is screened by gas chromatography-mass spectrometry (GC-MS) method and the evaluation of antimicrobial and antioxidant activities of the essential oils.

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Analysis of the anti-inflammatory properties of Rosmarinus officinalis L. in mice

Cited by 81 publications

References 28 publications

Rosmarinus Officinalis (Rosemary): A Novel Therapeutic Agent for Antioxidant, Antimicrobial, Anticancer,Antidiabetic, Antidepressant, Neuroprotective, Anti-Inflammatory, and Anti-Obesity Treatment

Rosmarinus Officinalis (Rosemary): A Novel Therapeutic Agent for Antioxidant, Antimicrobial, Anticancer,Antidiabetic, Antidepressant, Neuroprotective, Anti-Inflammatory, and Anti-Obesity Treatment

Evaluation of anti-cancer and immunomodulatory effects of carnosol in a Balb/c WEHI-164 fibrosarcoma model

Phytochemistry, Antioxidant, Antibacterial Activity, and Medicinal Uses of Aromatic (Medicinal Plant Rosmarinus officinalis)

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