Analysis of the affected joints in rheumatoid arthritis patients in a large Japanese cohort

Kanazawa, Takemichi; Nishino, Jinju; Tohma, Shigeto; Tanaka, Sakae

doi:10.1007/s10165-012-0636-7

Cited by 13 publications

(16 citation statements)

References 12 publications

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“…However, the main limitation of our study lies in the 11 (27%) countries where only one rheumatologist participated. Referent studies from Switzerland (mean age of RAO 51.5 years) [49], Japan (49 years) [50], Kenya (41 ± 17 years) [51], Nigeria (42 years) [52], Sweden (58 ± 18 years) [14], Russia (53 years) [53], Colombia (44 ± 12 years) [54], Burkina Faso (35 years) [55], and Iran (41 ± 13 years) [56] reported figures similar to ours. We did not find referent studies from Ghana or Panama.…”

Section: Discussionsupporting

confidence: 86%

Latitude gradient influences the age of onset of rheumatoid arthritis: a worldwide survey

2016

Clin Rheumatol

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The age of onset of rheumatoid arthritis (RA) is an important outcome predictor. Northern countries report an age of RA onset of around 50 years, but apparently, variability exists across different geographical regions. The objective of the present study is to assess whether the age of onset of RA varies across latitudes worldwide. In a proof-of-concept cross-sectional worldwide survey, rheumatologists from preselected cities interviewed 20 consecutive RA patients regarding the date of RA onset (RAO, when the patient first noted a swollen joint). Other studied variables included location of each city, rheumatologist settings, latitudes (10° increments, south to north), longitudes (three regions), intracountry consistency, and countries' Inequality-adjusted Human Development Index (IHDI). Data from 2481 patients (82% females) were obtained from 126 rheumatologists in 77 cities of 41 countries. Worldwide mean age of RAO was 44 ± 14 years (95% CI 44-45). In 28% of patients, RA began before age 36 years and before age 46 years in 50% of patients. RAO was 8 years earlier around the Tropic of Cancer when compared with northern latitudes (p < 0.001, 95% CI 3.5-13). Multivariate analysis showed that females, western cities, and latitudes around the Tropic of Cancer are associated with younger age of RAO (R 0.045, p< 0.001). A positive correlation was found between the age of RAO and IHDI (r = 0.7, p < 0.01, R 0.5). RA often begins at an early age and onset varies across latitudes worldwide. We postulate that countries' developmental status and their geographical and geomagnetic location influence the age of RAO.

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Section: Discussionsupporting

confidence: 86%

Latitude gradient influences the age of onset of rheumatoid arthritis: a worldwide survey

2016

Clin Rheumatol

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“…This was the first study that explored the relationship between the initially affected joint and the final diagnosis. Kanazawa et al . indicated that the wrist was the most frequently affected site in RA patients.…”

Section: Discussionmentioning

confidence: 99%

“…This was the first study that explored the relationship between the initially affected joint and the final diagnosis. Kanazawa et al 19 indicated that the wrist was the most frequently affected site in RA patients. This finding is in accordance with the present study, which demonstrated that wrist joint involvement is a predictor of monoarticular RA.…”

Section: Figurementioning

confidence: 99%

Clinical courses and predictors of outcomes in patients with monoarthritis: a retrospective study of 171 cases

et al. 2013

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“…Although patients were generally not evaluated at the time of diagnosis, the scarcity of available evidence suggests differences in RA phenotype in various populations. 13 14 Therefore, we studied the distribution of joint inflammation at the time of diagnosis in different RA populations (Mexican, Dutch, Indian and South African). In addition, within the Indian and Dutch populations, the joint distribution was subsequently compared between autoantibody-positive and negative patients with RA.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the joint distribution at disease presentation of patients with rheumatoid arthritis: a large study across continents

Bergstra

Chopra²,

Saluja³

et al. 2017

RMD Open

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BackgroundGenetic and environmental risk factors for rheumatoid arthritis (RA) are population dependent and may affect disease expression. Therefore, we studied tender and swollen joint involvement in patients newly diagnosed with RA in four countries and performed a subanalysis within countries to assess whether the influence of autoantibody positivity affected disease expression.MethodsPatients with symptom duration <2 years fulfilling the American College of Rheumatology/European League Against Rheumatism 2010 RA classification criteria were selected from METEOR (Measurement of Efficacy of Treatment in the Era of Outcome in Rheumatology), an international observational database, and the Dutch Leiden Early Arthritis Clinic. Indian (n=947), Mexican (n=141), South African (n=164) and Dutch (n=947) autoantibody-positive and negative patients with RA, matched by symptom duration, were studied for swollen and tender joint distribution.ResultsBetween countries, the reported distribution of swollen joint distribution differed, with more knee synovitis in Mexico, South Africa and India compared with the Netherlands (37%, 36%, 30% and 13%) and more elbow (29%, 23%, 7%, 7%) and shoulder synovitis (21%, 11%, 0%, 1%) in Mexico and South Africa compared with India and the Netherlands.Since the number of autoantibody-negative patients in Mexico and South Africa was limited, Indian and Dutch autoantibody-positive and negative patients with RA were compared. The number of swollen and tender joints was higher in autoantibody-negative patients, but the overall distribution of involved joints was similar.ConclusionJoint involvement at diagnosis does not differ between autoantibody-positive and negative patients with RA in India and the Netherlands. However, joint involvement is reported differently across countries. More research is needed whether these differences are cultural and/or pathogenetic.

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Analysis of the affected joints in rheumatoid arthritis patients in a large Japanese cohort

Cited by 13 publications

References 12 publications

Latitude gradient influences the age of onset of rheumatoid arthritis: a worldwide survey

Latitude gradient influences the age of onset of rheumatoid arthritis: a worldwide survey

Clinical courses and predictors of outcomes in patients with monoarthritis: a retrospective study of 171 cases

Evaluation of the joint distribution at disease presentation of patients with rheumatoid arthritis: a large study across continents

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