Analysis of the acoustic response of vascular tissue irradiated by an ultraviolet laser pulse

Crazzolara, H.; Muench, W. von; Rose, Carsten; Thiemann, U.; Haase, Karl K.; Ritter, Mark A.; Karsch, Karl R.

doi:10.1063/1.350356

Cited by 27 publications

(11 citation statements)

References 3 publications

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“…Pressure waves-rather than shockwaveshave been identified as secondary phenomena occuring during excimer laser tissue interaction [9]. As it has been shown in the results section, a good correlation of the magnitude of the generated pressure waves and the applied energy density can be found.…”

Section: Discussionmentioning

confidence: 85%

Perspectives of coronary excimer laser angioplasty: Multiplexing, saline flushing, and acoustic ablation control

et al. 1997

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Section: Discussionmentioning

confidence: 85%

Perspectives of coronary excimer laser angioplasty: Multiplexing, saline flushing, and acoustic ablation control

et al. 1997

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“…However, the concept of tissue ablation without injury to adjacent vessel wall structures 2141 seems to be limited because intimal dissections and perforations were documented following laser angioplasty [ 13,15,161. The observation of a rapidly expanding and then collapsing vapour bubble [61 and the occurrence of pressure waves [1,4,17,181, both of which are associated with the ablation of vascular tissue, may explain the trauma to vessel wall structures next to the irradiated area [4,6,191. Excimer laser light with a wavelength of 308 nm is absorbed in blood.…”

Section: Discussionmentioning

confidence: 99%

“…For the detection of acoustic signals generated by the laser pulse, hydrophones with active diameters of 0.5 mm were used as previously described [1,2]. Briefly, the hydrophones are fabricated from a 0.5 mm diameter, 9-Fm-thick polyvinilidenefluoride piezoelectric film bonded onto a 0.5-mm-thick metal needle (Instiute for Semicinductor Technology, Stuttgart, Germany).…”

Section: Introductionmentioning

confidence: 99%

Formation of pressure waves during in vitro excimer laser irradiation in whole blood and the effect of dilution with contrast media and saline

Baumbach¹,

Haase²,

Rose

et al. 1994

Lasers Surg Med

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Pressure waves during excimer laser ablation of vascular tissue may be responsible for complications of coronary excimer laser angioplasty. In this experimental study, pressure waves were measured during excimer laser irradiation in blood and contrast media using a polyvinilidenefluoride hydrophone. At a distance of 4 mm lateral to the tip of a 1.7 mm multifiber laser catheter, excimer laser irradiation in blood resulted in a linear increase of peak pressures from 1,365 +/- 165 kPa at 30 mJ/mm2 to 2,866 +/- 404 kPa at 60 mJ/mm2. In contrast media, peak pressure increased from 3,172 +/- 573 kPa (30 mJ/mm2) to 5,763 +/- 467 kPa (60 mJ/mm2). Contrast media and saline were added to blood. At a concentration of 60% contrast in blood, a 3.4 fold increase of peak pressures was documented as compared to pure blood. Further increase of the concentration did not result in higher pressure waves. Concentrations of saline in blood of 90% and 96% reduced the peak pressures by 16% and > 50%, respectively, as compared to pure blood.

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“…Opto-acoustic spectroscopy has been used to characterize in vitro vascular tissues [32], working both in thermoelastic [37] and ablation regime [38]: the in vitro sample is immersed in a liquid in which ultrasound can propagate, according to the experimental setup sketched in Fig. 1(b).…”

Section: B Opto-acoustic Spectroscopymentioning

confidence: 99%

Toward virtual biopsy through an all fiber optic ultrasonic miniaturized transducer: a proposal

Acquafresca

Biagi

Masotti

et al. 2003

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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The present generation of devices based on opto-acoustic and acousto-optic conversion lets us foresee the possibility of realizing complete miniaturized transmitting-receiving transducers, able to generate and detect wideband ultrasounds by laser light. In the present paper, a miniaturized ultrasonic transducer entirely based on fiber optic technology is proposed. Such a device springs from the conjunction between our research, which has produced a highly efficient fiber optic opto-acoustic source, with the results obtained by other researchers concerning the realization of an ultrasonic receiver based on optical interferometry. Making use of the thermo-elastic effect for ultrasound generation, a source of ultrasound can be obtained by coupling a fiber optic to pulsed laser, if a film capable of absorbing laser light is placed onto fiber end. Starting from these remarks, we propose an efficient opto-acoustic source, able to generate pressure pulses with amplitude of the order of 10 4 Pa and bandwidth extending up to 40 MHz and beyond by using graphite materials as absorbing film. This solution makes use of a low-power pulsed laser as optical source possible. An ultrasonic receiving element was realized placing a Fabry-Perot cavity over the tip of a fiber optic. The cavity thickness modulation induced by ultrasonic beam is detected by an interferometer optical technique. We have realized a prototype of a receiving device that exhibits a sensitivity comparable with that of piezoelectric devices (10-100 nV/Pa) and an almost flat bandwidth extending up to 20 MHz or more. The extreme miniaturization of the resulting ultrasonic transducer, together with its wide ultrasonic frequency bandwidth, is the first step toward ultrasonic tissue biopsy. In this paper, before discussing the problem of constructing a complete ultrasonic transducer composed by a transmitter and receiver, the results carried out in these fields during the last decade are reviewed.

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Analysis of the acoustic response of vascular tissue irradiated by an ultraviolet laser pulse

Cited by 27 publications

References 3 publications

Perspectives of coronary excimer laser angioplasty: Multiplexing, saline flushing, and acoustic ablation control

Perspectives of coronary excimer laser angioplasty: Multiplexing, saline flushing, and acoustic ablation control

Formation of pressure waves during in vitro excimer laser irradiation in whole blood and the effect of dilution with contrast media and saline

Toward virtual biopsy through an all fiber optic ultrasonic miniaturized transducer: a proposal

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