Analysis of<sup>11</sup>C-methionine Uptake in Low-Grade Gliomas and Correlation with Proliferative Activity

Kato, Takayuki; Shinoda, Jun; Oka, Naoki; Miwa, Kazuhiro; Nakayama, Noriyuki; Yano, Hirohito; Maruyama, Takashi; Muragakı, Yoshihiro; Iwama, Toru

doi:10.3174/ajnr.a1242

Cited by 89 publications

(61 citation statements)

References 29 publications

(41 reference statements)

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“…[33][34][35][36] Some of those reports have shown positive correlations between the T/N ratio of 11 C-methionine PET and the Mib-1 labeling index, which reflects tumor proliferation capability. [34][35][36] On the other hand, others have shown a positive correlation between the T/N ratio and microvessel density, which is considered to reflect angiogenesis. 33 It should be noted that these nonstereotactic studies seem less accurate compared with stereotactic image-histology comparisons, as gliomas consist of heterogeneous tissues.…”

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confidence: 99%

“…32,33 Previous reports have analyzed correlations among 11 C-methionine uptake, tumor proliferative ability, and angiogenesis. 22,[33][34][35][36] Several reports have been based on a comparison of the highest indices of each of these parameters. [33][34][35][36] Some of those reports have shown positive correlations between the T/N ratio of 11 C-methionine PET and the Mib-1 labeling index, which reflects tumor proliferation capability.…”

mentioning

confidence: 99%

“…22,[33][34][35][36] Several reports have been based on a comparison of the highest indices of each of these parameters. [33][34][35][36] Some of those reports have shown positive correlations between the T/N ratio of 11 C-methionine PET and the Mib-1 labeling index, which reflects tumor proliferation capability. [34][35][36] On the other hand, others have shown a positive correlation between the T/N ratio and microvessel density, which is considered to reflect angiogenesis.…”

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confidence: 99%

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¹¹C‐methionine uptake and intraoperative 5‐aminolevulinic acid‐induced fluorescence as separate index markers of cell density in glioma

Arita

Kinoshita

Kagawa

et al. 2011

Cancer

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BACKGROUND:The extent of tumor resection is acknowledged as 1 of the prognostic factors for glioma. 5-Aminolevulinic acid (5-ALA)-induced fluorescence guidance and neuronavigation integrated with 11 C-methionine positron emission tomography (PET) are widely utilized under the expectation of improving the extent of resection. These 2 novel approaches are beneficial for glioma resections, and the combination of these approaches appears rational. However, biological characteristics reflecting 5-ALA-induced fluorescence and 11 C-methionine uptake have not been clearly elucidated, and studies about the relationship between 5-ALA-induced fluorescence and 11 C-methionine uptake have been limited. The present study aimed to clarify this issue. METHODS: Data from 11 consecutive patients harboring astrocytic tumors were analyzed: 2 grade II and 2 grade III, and 7 grade IV tumors were included. Thirty samples from these patients were obtained from the relative periphery of each tumor. Relationships among histology, 5-ALA-induced fluorescence and 11 C-methionine uptake were analyzed by stereotactic sampling and image analysis. RESULTS:Uptake of 11 C-methionine correlated with cell density (R 2 ¼ 0.322, P ¼ .0059). Cell density was higher in fluorescence-positive areas than in negative areas (2760 AE 1080 vs 1450 AE 1380/mm 2 , P ¼ .0132). Although both 11 C-methionine uptake and fluorescence seemed to correlate with cell density, no significant difference in 11 C-methionine uptake was seen between fluorescence-positive and -negative areas (P ¼ .367). Multiple linear regression analysis revealed 11 C-methionine uptake and 5-ALA-induced fluorescence as independent indices for tumor cell density. CONCLUSIONS:These results indicate that 5-ALA fluorescence and 11 C-methionine PET image are separate index markers for cytoreduction surgery of gliomas.

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¹¹C‐methionine uptake and intraoperative 5‐aminolevulinic acid‐induced fluorescence as separate index markers of cell density in glioma

Arita

Kinoshita

Kagawa

et al. 2011

Cancer

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“…1,2,7,10,20,22,23 The diagnostic validity of PET for patients with brain tumors has been established for evaluating tumor malignancy, therapeutic response, or differentiation of tumor recurrence from tissue necrosis. However, few studies on spinal intramedullary lesions have been reported.…”

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confidence: 99%

“…In the diagnosis of central nervous system tumors, the usefulness of these radiotracers for brain tumors has been established for evaluating malignancies, therapeutic response, or differentiation of tumor recurrence from tissue necrosis. 1,2,7,10,20,22,23 However, investigations of spinal intramedullary tumors using PET remain sporadic, with only case reports or case series available to date. 5,6,8,11,13,[15][16][17]18 PET diagnosis of spinal intramedullary tumors can- 18 F]-fluorodeoxyglucose (FDG)-PET/CT was performed in 26 patients with spinal intramedullary lesions.…”

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Qualitative analysis of spinal intramedullary lesions using PET/CT

Naito

Yamagata

Arima³

et al. 2015

SPI

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OBJECT Although the usefulness of PET for brain lesions has been established, few reports have examined the use of PET for spinal intramedullary lesions. This study investigated the diagnostic utility of PET/CT for spinal intramedullary lesions. METHODS l-[methyl-11C]-methionine (MET)- or [18F]-fluorodeoxyglucose (FDG)-PET/CT was performed in 26 patients with spinal intramedullary lesions. The region of interest (ROI) within the spinal cord parenchyma was placed manually in the axial plane. Maximum pixel counts in the ROIs were normalized to the maximum standardized uptake value (SUVmax) using subject body weight. For FDG-PET the SUVmax was corrected for lean body mass (SULmax) to exclude any influence of the patient’s body shape. Each SUV was analyzed based on histopathological results after surgery. The diagnostic validity of the SUV was further compared with the tumor proliferation index using the MIB-1 monoclonal antibody (MIB-1 index). RESULTS A total of 16 patients underwent both FDG-PET and MET-PET, and the remaining 10 patients underwent either FDG-PET or MET-PET. Pathological diagnoses included high-grade malignancy such as glioblastoma multiforme, anaplastic astrocytoma, or anaplastic ependymoma in 5 patients; low-grade malignancy such as hemangioblastoma, diffuse astrocytoma, or ependymoma in 12 patients; and nonneoplastic lesion including cavernous malformation in 9 patients. Both FDG and MET accumulated significantly in high-grade malignancy, and the SULmax and SUVmax correlated with the tumor proliferation index. Therapeutic response after chemotherapy or radiation in high-grade malignancy was well monitored. However, a significant difference in SULmax and SUVmax for FDG-PET and MET-PET was not evident between low-grade malignancy and nonneoplastic lesions. CONCLUSIONS Spinal PET/CT using FDG or MET for spinal intramedullary lesions appears useful and practical, particularly for tumors with high-grade malignancy. Differentiation of tumors with low-grade malignancy from nonneoplastic lesions may still prove difficult. Further technological refinement, including the selection of radiotracer or analysis evaluation methods, is needed.

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A computational study on the reactivity enhancement in the free radical polymerization of alkyl α‐hydroxymethacrylate and acrylate derivatives

Karahan

Avi̇yente

Avcı

et al. 2012

J. Polym. Sci. A Polym. Chem.

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The free radical polimerizability behavior of alkyl α‐hydroxymethacrylate (RHMA) derivatives (M1–M3) has been modeled by considering the propagation of the dimeric units of the compounds of interest. All the transition structures in this class of monomers are stabilized by long‐range CO…HC interactions. The RHMA monomer bearing the ester functionality (M2) polymerizes slightly faster than the one with the ether functionality (M1) because of stronger electrostatic interactions between the CO and HC groups. 2‐(Methoxycarbonyl)allyl benzoate (M3) shows higher reactivity as compared to M1 and M2 due to stronger electrostatic interactions. The same type of study has been carried out for hexyl (M4), benzyl (M5), and phenyl (M6) acrylate derivatives whose increasing reactivity has been attributed to the presence of CO…HC, CO…H‐ϕ as well as π–π stabilizing interactions, respectively. While B3LYP/6‐31+G(d) has been used to locate the stationary points along the free radical polymerization of nonaromatic species, long‐range stabilizing interactions have only been detected with M06‐2X/6‐31+G(d). The kinetics that we obtain with this latter methodology for the free radical polymerization reactions of M1–M6 agree well qualitatively with experiment. An implicit solvent model has reproduced the kinetics of M1–M3 in benzene the best. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013

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Analysis of¹¹C-methionine Uptake in Low-Grade Gliomas and Correlation with Proliferative Activity

Cited by 89 publications

References 29 publications

¹¹C‐methionine uptake and intraoperative 5‐aminolevulinic acid‐induced fluorescence as separate index markers of cell density in glioma

¹¹C‐methionine uptake and intraoperative 5‐aminolevulinic acid‐induced fluorescence as separate index markers of cell density in glioma

Qualitative analysis of spinal intramedullary lesions using PET/CT

A computational study on the reactivity enhancement in the free radical polymerization of alkyl α‐hydroxymethacrylate and acrylate derivatives

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Analysis of11C-methionine Uptake in Low-Grade Gliomas and Correlation with Proliferative Activity

Cited by 89 publications

References 29 publications

11C‐methionine uptake and intraoperative 5‐aminolevulinic acid‐induced fluorescence as separate index markers of cell density in glioma

11C‐methionine uptake and intraoperative 5‐aminolevulinic acid‐induced fluorescence as separate index markers of cell density in glioma

Qualitative analysis of spinal intramedullary lesions using PET/CT

A computational study on the reactivity enhancement in the free radical polymerization of alkyl α‐hydroxymethacrylate and acrylate derivatives

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Product

Resources

About

Analysis of¹¹C-methionine Uptake in Low-Grade Gliomas and Correlation with Proliferative Activity

¹¹C‐methionine uptake and intraoperative 5‐aminolevulinic acid‐induced fluorescence as separate index markers of cell density in glioma

¹¹C‐methionine uptake and intraoperative 5‐aminolevulinic acid‐induced fluorescence as separate index markers of cell density in glioma