Analysis of Summating Potential in Cochlear Responses of Guinea Pigs

Goldstein, Robert E.

doi:10.1152/ajplegacy.1954.178.2.331

Cited by 25 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Opposing polarity generation of IHC to OHC has been suggested in the literature since SP's infancy. Many have concluded that IHC generate a positive deflection and OHC a negative one (Goldstein 1954;Johnstone & Johnstone 1966;Helmstaedter et al 2018;Pappa et al 2019), which is consistent with the findings in our study. However, the inverse has also been described (Davis et al 1958;Dallos & Cheatham 1976;Rea & Gibson 2003).…”

Section: Discussionsupporting

confidence: 93%

“…The composition and cellular generators of the SP have long been contended. Some early work described three separate generators (OHC, inner hair cells [IHC], and ANF) of d.c. deflection with different amplitude and polarity qualities ( Goldstein 1954 ). Others have contended solely OHC ( Dallos & Cheatham 1976 ) or primarily IHC generation ( Zheng et al 1997 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Characteristics of the Summating Potential Measured Across a Cochlear Implant Array as an Indicator of Cochlear Function

2023

View full text Add to dashboard Cite

Objectives: The underlying state of cochlear and neural tissue function is known to affect postoperative speech perception following cochlear implantation. The ability to assess these tissues in patients can be performed using intracochlear electrocochleography (IC ECochG). One component of ECochG is the summating potential (SP) that appears to be generated by multiple cochlear tissues. Its qualities may be able to detect the presence of functional inner hair cells, but evidence for this is limited in human cochleae. This study aimed to examine the IC SP characteristics in cochlear implantation recipients, its relationship to preoperative speech perception and audiometric thresholds, and to other IC ECochG components. Design: This is a retrospective analysis of 113 patients’ IC ECochG recordings across the array in response to a 500 Hz tone burst stimulus. Responses to condensation and rarefaction stimuli were then subtracted from one another to emphasize the cochlear microphonic and added to one another to emphasize the SP, auditory nerve neurophonic, and compound action potential. Patients were grouped based on their maximum SP deflection being large and positive (+SP), large and negative (−SP), or minimal (0 SP) to further investigate these relationships. Results: Patients in the +SP group had better preoperative speech perception (mean consonant-vowel-consonant phoneme score 46%) compared to the −SP and 0 SP groups (consonant-vowel-consonant phoneme scores 34% and 36%, respectively, difference to +SP: p < 0.05). Audiometric thresholds were lowest for +SP (mean pure-tone average 50 dB HL), then −SP (65 dB HL), and highest for 0 SP patients (70 dB HL), but there was not a statistical significance between +SP and −SP groups (p > 0.1). There were also distinct differences between SP groups in the qualities of their other ECochG components. These included the +SP patients having larger cochlear microphonic maximum amplitude, more apical SP peak electrode locations, and a more spatially specific SP magnitude growth pattern across the array. Conclusions: Patients with large positive SP deflection in IC ECochG have preoperatively better speech perception and lower audiometric thresholds than those without. Patterns in other ECochG components suggest its positive deflection may be an indicator of cochlear function.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Characteristics of the Summating Potential Measured Across a Cochlear Implant Array as an Indicator of Cochlear Function

2023

View full text Add to dashboard Cite

show abstract

“…The SP evoked by a tone burst or noise burst gives rise to a DC voltage shift from baseline that continues over the duration of the stimulus. The SP is thought to arise predominantly from the IHC or its afferent terminal ( Goldstein, 1954 , Tasaki et al., 1954 , Davis et al., 1958 , Dallos et al., 1972 , Ding et al., 1993 , Ding et al., 1996 , Ding et al., 2010b , Zheng et al., 1997 , Ding and Jin, 1998 , Durrant et al., 1998 ). Diuretics typically induce a high positive SP no matter if the original polarity was positive or negative; this effect recovered slowly in conjunction with the recovery of the EP and CM ( Syka and Melichar, 1985 , Rybak, 1993 , Ding et al., 1996 , Ding et al., 2004 , Ding et al., 2010b ).…”

Section: Reversible Diuretics-induced Changes In Cochlear Potentialsmentioning

confidence: 99%

Ototoxic effects and mechanisms of loop diuretics

Ding

et al. 2016

Journal of Otology

View full text Add to dashboard Cite

Over the past two decades considerable progress has been made in understanding the ototoxic effects and mechanisms underlying loop diuretics. As typical representative of loop diuretics ethacrynic acid or furosemide only induces temporary hearing loss, but rarely permanent deafness unless applied in severe acute or chronic renal failure or with other ototoxic drugs. Loop diuretic induce unique pathological changes in the cochlea such as formation of edematous spaces in the epithelium of the stria vascularis, which leads to rapid decrease of the endolymphatic potential and eventual loss of the cochlear microphonic potential, summating potential, and compound action potential. Loop diuretics interfere with strial adenylate cyclase and Na+/K+-ATPase and inhibit the Na-K-2Cl cotransporter in the stria vascularis, however recent reports indicate that one of the earliest effects in vivo is to abolish blood flow in the vessels supplying the lateral wall. Since ethacrynic acid does not damage the stria vascularis in vitro, the changes in Na+/K+-ATPase and Na-K-2Cl seen in vivo may be secondary effects results from strial ischemia and anoxia. Recent observations showing that renin is present in pericytes surrounding stria arterioles suggest that diuretics may induce local vasoconstriction by renin secretion and angiotensin formation. The tight junctions in the blood-cochlea barrier prevent toxic molecules and pathogens from entering cochlea, but when diuretics induce a transient ischemia, the barrier is temporarily disrupted allowing the entry of toxic chemicals or pathogens.

show abstract

“…The behaviour of SP during anoxia is similar to CM in that it is reduced as + EP falls. However, it may change its polarity twice during the fall of +EP (Goldstein, 1954). Neither SP or CM have a latency and they both change phase or polarity when an electrode travels from scala tympani to scala media.…”

Section: Summating Potentialsmentioning

confidence: 99%

The peripheral auditory apparatus

Johnstone

Sellick

1972

Quart. Rev. Biophys.

125

View full text Add to dashboard Cite

This review of the peripheral auditory apparatus represents an attempt to analyse critically recent developments in the field. The coverage is not exhaustive, the emphasis is on functional aspects and no attempt is made to review the anatomy of the ear. Particular emphasis is placed on three broad sections: the physiology of the middle ear, basilar membrane mechanics and the electrophysiology of the cochlea. It is in these areas that recent technical advances have led to experiments which throw doubt on traditionally held concepts. Such an advance is the application of the Mössbauer technique to the problem of middle- and inner-ear mechanics. Because of its novelty, this technique is discussed in detail. Other new methods such as laser holography are just starting to be used, as are the ion selective microelectrodes for measuring dynamic changes in endolymph concentration. After many years of slow progress there is a sudden spark of enthusiasm for peripheral auditory research, and the coming decade promises to be most exciting indeed.

show abstract

Analysis of Summating Potential in Cochlear Responses of Guinea Pigs

Cited by 25 publications

References 0 publications

Characteristics of the Summating Potential Measured Across a Cochlear Implant Array as an Indicator of Cochlear Function

Characteristics of the Summating Potential Measured Across a Cochlear Implant Array as an Indicator of Cochlear Function

Ototoxic effects and mechanisms of loop diuretics

The peripheral auditory apparatus

Contact Info

Product

Resources

About