Analysis of structural organization and interaction mechanisms of detonation nanodiamond particles in hydrosols

Knizhnik, Andrey A.; Polynskaya, Yulia G.; Sinitsa, Alexander S.; Kuznetsov, Nikita M.; Белоусов, С. И.; Чвалун, С. Н.; Потапкин, Б. В.

doi:10.1039/d0cp05533f

Cited by 10 publications

(5 citation statements)

References 53 publications

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“…As mentioned above, there are many functional groups on the surface of DNDs and these functional groups can have a significant effect on the properties of DNDs. In recent studies the aggregation stability of DNDs hydrosols has been related to the interaction of charged particles in the functional groups on the surface [ 16 , 17 ]. Dispersion of DND aggregates using a range of modalities contributes to the formation of stable aqueous suspensions of DNDs.…”

Section: Fluorescence Imagingmentioning

confidence: 99%

Multiple Bioimaging Applications Based on the Excellent Properties of Nanodiamond: A Review

Wang,

Sang,

Zou

et al. 2023

Molecules

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Nanodiamonds (NDs) are emerging as a promising candidate for multimodal bioimaging on account of their optical and spectroscopic properties. NDs are extensively utilized for bioimaging probes due to their defects and admixtures in their crystal lattice. There are many optically active defects presented in NDs called color centers, which are highly photostable, extremely sensitive to bioimaging, and capable of electron leap in the forbidden band; further, they absorb or emit light when leaping, enabling the nanodiamond to fluoresce. Fluorescent imaging plays a significant role in bioscience research, but traditional fluorescent dyes have some drawbacks in physical, optical and toxicity aspects. As a novel fluorescent labeling tool, NDs have become the focus of research in the field of biomarkers in recent years because of their various irreplaceable advantages. This review primarily focuses on the recent application progress of nanodiamonds in the field of bioimaging. In this paper, we will summarize the progress of ND research from the following aspects (including fluorescence imaging, Raman imaging, X-ray imaging, magnetic modulation fluorescence imaging, magnetic resonance imaging, cathodoluminescence imaging, and optical coherence tomography imaging) and expect to supply an outlook contribution for future nanodiamond exploration in bioimaging.

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Section: Fluorescence Imagingmentioning

confidence: 99%

Multiple Bioimaging Applications Based on the Excellent Properties of Nanodiamond: A Review

Wang,

Sang,

Zou

et al. 2023

Molecules

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“…Such information is especially important in a biomedical context, since different particle shapes and aggregation may influence cell uptake and cell viability . Moreover, newer research has revealed the polydisperse and aggregated nature of DNDs in aqueous media, − most likely due to their complex surface structures. ,, Unlike standard colloidal systems where particle assembly and (prevention of) aggregation can be controlled by surfactants, , theoretical calculations have shown that DNDs exhibit facet-dependent, unisotropical surface electrostatic potential distributions. These electrostatic potentials have been shown to promote ordered facet–facet connections resulting in chain and loop assemblies , which have been observed using transmission electron microscopy (TEM) (see Figure S1).…”

Section: Introductionmentioning

confidence: 99%

“…Cryo-TEM, unlike conventional TEM, holds the advantages of imaging the sample frozen in its native state, hence providing information about the dynamic formation process at high spatial resolution. It has been previously used for DND suspension characterization; ,, however, it has not been used to provide statistical analysis comparable with the bulk sample analysis like DLS and SAXS. Quantitative image analysis using ML allows us to process a large amount of image data and gain more statistics about the ensemble behavior of DNDs in solution.…”

Section: Introductionmentioning

confidence: 99%

Complex Dispersion of Detonation Nanodiamond Revealed by Machine Learning Assisted Cryo-TEM and Coarse-Grained Molecular Dynamics Simulations

et al. 2023

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Understanding the polydispersity of nanoparticles is crucial for establishing the efficacy and safety of their role as drug delivery carriers in biomedical applications. Detonation nanodiamonds (DNDs), 3−5 nm diamond nanoparticles synthesized through detonation process, have attracted great interest for drug delivery due to their colloidal stability in water and their biocompatibility. More recent studies have challenged the consensus that DNDs are monodispersed after their fabrication, with their aggregate formation poorly understood. Here, we present a novel characterization method of combining machine learning with direct cryotransmission electron microscopy imaging to characterize the unique colloidal behavior of DNDs. Together with small-angle X-ray scattering and mesoscale simulations we show and explain the clear differences in the aggregation behavior between positively and negatively charged DNDs. Our new method can be applied to other complex particle systems, which builds essential knowledge for the safe implementation of nanoparticles in drug delivery.

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“…It is extremely important to understand the nature of different DNDs behavior under an electric field for practical application. Although today there are studies on the mechanism of the positive electrorheological effect of hydrogenated DND particles [18,19], much less is known about the reasons for the electrophoresis of particles with a carboxylated surface. Since particles must be charged for electrophoresis, two hypotheses have been proposed in previous study to explain this phenomenon [20].…”

Section: Introductionmentioning

confidence: 99%

The Nature of the Electrorheological and Electrophoretic Effects of Detonation Nanodiamonds Suspensions in Mineral Oil

2022

Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol.

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Qualitative differences in the nature of the electrorheological response of a detonation nanodiamonds suspensions in mineral oil depending on the type of particle surface functionalization were established from a number of rotational and oscillation tests. The type of modification and the chemical composition of the surface for particles of hydrogenated and carboxylated nanodiamonds were studied by infrared spectroscopy. Particles morphology and their structural organization in a mineral oil medium were studied by small-angle X-ray scattering method. It was found that suspensions of hydrogenated and carboxylated particles under an electric field exhibit an electrorheological and electrophoretic effects, respectively. The reasons for the electrophoretic motion of carboxylated nanodiamonds in a mineral oil medium were analyzed in comparison with the previously observed effect in the medium of weakly amphiphilic polydimethylsiloxane (silicon oil). The water content on the surface of both hydrogenated and carboxylated nanodiamond particles was determined by Karl Fischer titration of suspensions. The correlation between the electrophoretic effect and the adsorbed water content on the surface of the particles was suggested. The method of rotational viscometry revealed the dependences of the static yield stress for suspensions filled with hydrogenated and carboxylated nanodiamonds at various electric field strength. The flow curves of the fluid filled with hydrogenated particles without and under an electric field were fitted by Bingham and Cho-Choi-Jhon rheological models. An analysis of the used models matching to practical results was performed. Based on the dependences of the storage and loss moduli on the deformation amplitude, a linear range of the viscoelastic properties of the fluid was revealed. An increase in the values of the storage and loss moduli, as well as a narrowing of the linear viscoelasticity range with an increase in the electric field strength was detected.

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Analysis of structural organization and interaction mechanisms of detonation nanodiamond particles in hydrosols

Abstract: Analysis of the structural organization of nanodiamond particles based on the interplay between Coulomb and van der Waals forces was performed.

Cited by 10 publications

References 53 publications

Multiple Bioimaging Applications Based on the Excellent Properties of Nanodiamond: A Review

Multiple Bioimaging Applications Based on the Excellent Properties of Nanodiamond: A Review

Complex Dispersion of Detonation Nanodiamond Revealed by Machine Learning Assisted Cryo-TEM and Coarse-Grained Molecular Dynamics Simulations

The Nature of the Electrorheological and Electrophoretic Effects of Detonation Nanodiamonds Suspensions in Mineral Oil

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