This work introduces a new design algorithm to optimize progressively folding thin-walled structures and in order to improve automotive crashworthiness. The proposed design algorithm is composed of three stages: conceptual thickness distribution, design parameterization, and multi-objective design optimization. The conceptual thickness distribution stage generates an innovative design using a novel one-iteration compliant mechanism approach that triggers progressive folding even on irregular structures under oblique impact. The design parameterization stage optimally segments the conceptual design into a reduced number of clusters using a machine learning K-means algorithm. Finally, the multiobjective design optimization stage finds non-dominated designs of maximum specific energy absorption and minimum peak crushing force. The proposed optimization problem is addressed by a multiobjective genetic algorithm on sequentially updated surrogate models, which are optimally selected from a set of 24 surrogates. The effectiveness of the design algorithm is demonstrated on an S-rail thin-walled structure. The best compromised Pareto design increases specific energy absorption and decreases peak crushing force in the order of 8% and 12%, respectively. Recently, our research group has proposed the use of HCA topometry (thickness distribution) methods for compliant, plastically deformable structures to support the generation of conceptual design for progressively folding thin-walled components including S-rails [28]. This method follows the design principles of compliant mechanisms and their ability to transfer force and displacement from a given input