Analysis of stage IVB endometrial carcinoma patients with distant metastasis: a review of prognoses in 55 patients

Numazaki, Reiko; Miyagi, Etsuko; Konnai, Katsuyuki; Ikeda, Masae; Yamamoto, Akihito; Onose, Ryo; Kato, Hiroyuki; Okamoto, Naoyuki; Hirahara, Fumiki; Nakayama, Hiroki

doi:10.1007/s10147-009-0878-3

Cited by 20 publications

(11 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lung metastasis was associated with better survival than brain metastasis, although no significant differences were observed when lung, liver, and bone metastases were compared. This result is partly consistent with that of Numazaki et al, 20 who reported that lung metastasis was associated with a better prognosis than non-lung hematogenous metastasis. Their observation may be related to the fact that women with brain metastasis were included in the group of women with non-lung hematogenous metastasis.…”

Section: Discussionsupporting

confidence: 92%

Prognostic value of distant metastatic sites in stage IV endometrial cancer: A SEER database study of 2948 women

Liu

Chi

Zhou

et al. 2020

Intl J Gynecology & Obste

View full text Add to dashboard Cite

Objective To evaluate the prognosis of women with distant metastasis at the time of endometrial cancer (EC) diagnosis and identify prognostic factors according to metastatic site. Methods A retrospective cohort study of women diagnosed with EC according to the SEER database between 2010 and 2014. Univariate and multivariate Cox regression was used to identify variables associated with overall survival. Kaplan‐Meier curves were used to compare survival among different groups. Results Overall, 2948 women with stage IV EC were identified. The most common distant metastatic site was the lung. Having a distant metastatic site independently predicted overall survival. Using brain metastasis as a reference, overall survival was longer for liver (P=0.049), lung (P=0.005), and bone (P=0.019) metastasis. Relative to no distant metastasis, overall survival was shorter for women with one (P<0.001) or two or more (P<0.001) sites of distant metastasis. Overall survival was independently influenced by tumor grade, insurance status, and surgery among women with only lung metastasis. Conclusion The findings showed that the prognosis of women with stage IV EC differs by distant metastatic site, and identified several predictors of poor survival. They may help clinicians to better predict prognosis for newly diagnosed cases of EC with distant metastasis.

show abstract

Section: Discussionsupporting

confidence: 92%

Prognostic value of distant metastatic sites in stage IV endometrial cancer: A SEER database study of 2948 women

Liu

Chi

Zhou

et al. 2020

Intl J Gynecology & Obste

View full text Add to dashboard Cite

show abstract

“…Therefore, EC patients with equivalent FIGO stages may have different prognoses, which may require different treatment strategies. Metastasis is relatively uncommon in patients with EC; therefore, only a small number of studies have evaluated the prognosis impact of different metastatic sites 7‐9 . However, these studies have focused on the description of a single metastatic site without comparing the survival impact of different metastasis sites.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of different metastatic sites for patients with FIGO stage IVB endometrial cancer after surgery: A SEER database analysis

Zhang

Chen

et al. 2020

Journal of Surgical Oncology

View full text Add to dashboard Cite

Objective This study aimed to investigate the association between different metastatic sites and survival in endometrial cancer (EC) patients with International Federation of Gynecology and Obstetrics (FIGO) stage IVB disease. Methods FIGO stage IVB patients with EC were selected from the surveillance, epidemiology, and end results database. Overall survival (OS) and cause‐specific survival (CSS) were analyzed with Kaplan‐Meier analysis and log‐rank tests. Univariate and multivariate Cox proportional hazard models were used to identify the prognostic factors for OS and CSS. Results A total of 929 FIGO stage IVB patients with EC were identified. Patients with peritoneum metastasis were associated with significantly better OS and CSS compared to those with organ‐specific metastasis (median OS: 29 vs 19 months, P = .005; median CSS: 47 vs 25 months, P < .001). Moreover, the survival superiority of peritoneum metastasis remained significant when organ‐specific metastasis was further classified into specific single‐organ metastasis. The multivariate analysis also indicated that compared with peritoneum metastasis, bone, brain, and lung metastasis were independent prognostic factors for worse OS. Similarly, distant lymph node, bone, brain, liver, and lung metastasis were associated with worse CSS. Conclusion Metastatic sites affected prognosis in FIGO stage IVB patients with EC. Patients with peritoneum metastasis had significantly better survival outcomes than those with organ‐specific metastasis.

show abstract

“…Cardiac myocytes are proliferative in the fetal heart but soon after birth ventricular myocytes become terminally differentiated and bi-nucleated and lose their ability to reenter the cell cycle [13–15]. There is an association between fetal myocyte proliferation and the presence of TTCCs and the reduced expression of TTCCs after birth is associated with the exit of ventricular myocytes from the cell cycle.…”

Section: Introductionmentioning

confidence: 99%

T-type Ca2+ channels regulate the exit of cardiac myocytes from the cell cycle after birth

Wang

Gao

Kubo

et al. 2013

Journal of Molecular and Cellular Cardiology

View full text Add to dashboard Cite

T-type Ca2+ channels (TTCCs) are expressed in the fetal heart and then disappear from ventricular myocytes after birth. The hypothesis examined in this study was the α1G TTCCs' influence in myocyte maturation and their rapid withdrawal from the cell cycle after birth. Methods Cardiac myocytes were isolated from neonatal and adult wild type (WT), α1G−/− and α1G over expressing (α1GDT) mice. Bromodeoxyuridine (BrdU) uptake, myocyte nucleation, cell cycle analysis, and T-type Ca2+ currents were measured. Results All myocytes were mono-nucleated at birth and 35% of WT myocytes expressed functional TTCCs. Very few neonatal myocytes had functional TTCCs in α1G−/− hearts. By the end of the first week after birth no WT or α1G−/− had functional TTCCs. During the first week after birth about 25% of WT myocytes were BrdU+ and became bi-nucleated. Significantly fewer α1G−/− myocytes became bi-nucleated and fewer of these myocytes were BrdU+. Neonatal α1G−/− myocytes were also smaller than WT. Adult WT and α1G−/− hearts were similar in size, but α1G−/− myocytes were smaller and a greater % were mono-nucleated. α1G over expressing hearts were smaller than WT but their myocytes were larger. Conclusions The studies performed show that loss of functional TTCCs is associated with bi-nucleation and myocyte withdrawal from the cell cycle. Loss of α1G TTCCs slowed the transition from mono- to bi-nucleation and resulted in an adult heart with a greater number of small cardiac myocytes. These results suggest that TTCCs are involved in the regulation of myocyte size and the exit of myocytes from the cell cycle during the first week after birth.

show abstract

Analysis of stage IVB endometrial carcinoma patients with distant metastasis: a review of prognoses in 55 patients

Abstract: For operable patients, surgery as an initial treatment and reduction of the residual tumor size to less than 2 cm appeared to contribute to a better prognosis. In addition, conservative initial treatment and the presence of non-lung hematogenous metastasis were poor prognostic factors.

Cited by 20 publications

References 18 publications

Prognostic value of distant metastatic sites in stage IV endometrial cancer: A SEER database study of 2948 women

Prognostic value of distant metastatic sites in stage IV endometrial cancer: A SEER database study of 2948 women

Prognostic value of different metastatic sites for patients with FIGO stage IVB endometrial cancer after surgery: A SEER database analysis

T-type Ca2+ channels regulate the exit of cardiac myocytes from the cell cycle after birth

Contact Info

Product

Resources

About