The heat pipe is a type of heat exchanger, which is widely used for thermal control because it has high possible heat transfer rate over a substantial distance with the low temperature drop. In this research work, the effect of heat exchange between hot and cold mass at different evaporator heat inputs on heat pipe heat exchanger efficiency and it is investigated for different inclination angles, heat inputs and adiabatic heat pipe lengths. Hybrid Nano-fluid, a mixture of 70 per cent of AL 2 O 3 and 30 per cent of TiO 2 Nano-fluidis used as working fluid with deionized water as the base fluid. The hot water mass flow rate (mh) of 0.2, 0.4, 0.6 and 0.8 litres per minute is used in the evaporator section. The cold-water mass flow rate (m c ) is maintained as 50% of m h throughout the experiment. The experimental tests are conducted for adiabatic lengths of 0 mm, 100 mm and 200 mm of Heat pipe oriented at inclination angles of 0°, 15°, 30°, and 45° at various heat inputs of 40, 60 and 80 W. The experimental findings showed that increasing adiabatic length reduces the heat pipe effectiveness. With increasing inclination angles for the whole hot water mass flow rate, the effectiveness of the heat pipe was increased. Compared to two other mass flow rates of 40 and 60 watts heat inputs at all the inclination angles, 0.2 and 0.4 ml water mass flow rate showed higher effectiveness. Whereas the heat input of 80 W had similar characteristics of efficiency except at angle of inclination of 45 °.