The present study involves a numerical approach of forced convection of the rheological properties of Casson nanofluids flowing on a vertical plate with variable viscosity and Prandtl number using Buongiorno's single-phase model. The non-Newtonian Casson fluid is very useful in the process of metal coatings and fabrication manufacturing as these types of nanofluids experiences more shear-thinning effects. The influence of velocity, concentration, and temperature profiles for nonuniform physical parameters on the steady Casson nanofluid flow induced on a vertical plate was studied numerically. The investigations include the graphs of velocity, concentration, temperature, skin friction coefficient, and Nusselt number profiles for velocity ratio parameter (ϵ), Casson fluid parameter (β), and Lewis number (Le). The characteristic features of augmented values of Casson fluid parameter (β) enhance the velocity profile, whereas declines the temperature profiles. Non-Newtonian fluids on a vertical plate are commonly encountered in irrigation problems, heat storage beds, biological systems, petroleum, textile, paper, and polymer composite industries, optimization and solidification processes of metals and