Analysis of Single Nucleotide Polymorphisms in the 5′‐Flanking Region of Tumor Necrosis Factor‐Alpha Gene in Japanese Patients With Early‐Onset Periodontitis

Abstract

These findings suggest there is no significant association between polymorphisms in the 5'-flanking region of the TNF-alpha gene and susceptibility to G-EOP in Japanese patients.

Analysis of TNF-α (-308) polymorphism and gingival crevicular fluid TNF-α levels in aggressive and chronic periodontitis: A preliminary report

“…The literature contains no other data regarding the association of TNF-a (-308) polymorphism and chronic periodontitis in a Turkish population. Majority of the studies in parallel to ours, revealed no significant difference between chronic periodontitis and healthy [17,[19][20][21]23,31,[33][34][35]. Kornmann et al [16], reported the frequency of TNF-a (-308) allele 2 20.9%, 38.1%, and 26.5% for severe, moderate and mild periodontitis respectively.…”

Association between TNF-α, TGF-β1, IL-10, IL-6 and IFN-γ gene polymorphisms and generalized aggressive periodontitis

“…11 Several case-control studies have been conducted to evaluate the role of TNF-α variants in peridontitis 32,[38][39][40][41][42][43][44] ; however, the results are inconsistent. While two studies suggest that TNF-α polymorphisms are factors affecting disease, 38,39 other researchers could not confirm any links between genetic variants and periodontitis.…”

“…While two studies suggest that TNF-α polymorphisms are factors affecting disease, 38,39 other researchers could not confirm any links between genetic variants and periodontitis. [40][41][42][43][44] These inconsistent data may be partly explained by the different clinical, methodological and statistical settings, as well as by variances in TNF genotype distributions within distinct races and /or populations. 45,46 In this study, we detected a statistically significant correlation between the genetic variant of TNF-α (-308G) and the occurrence of GAgP ( Table 2).…”

Influence of TNF gene polymorphisms in Japanese patients with NASH and simple steatosis

“…Regarding the TNF gene haplotype, because the frequency of polymorphism at À238 and À308 was very low, we classified these polymorphisms into four haplotypes (H1-H4) regarding three single nucleotide polymorphisms (À1031, À863, À857), according to Endo's paper [26]. The results are shown in Table 7.…”