Analysis of severe human adenovirus infection outbreak in Guangdong Province, southern China in 2019

Liu, Wenkuan; Qiu, Shuyan; Zhang, Li; Wu, Haishan; Tian, Xingui; Li, Xiao; Xu, Duo; Dai, Jing; Gu, Shujun; Lei, Qian; Chen, Dehui; Zhou, Rong

doi:10.1016/j.virs.2022.01.010

Cited by 21 publications

(24 citation statements)

References 38 publications

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“…In this study, the levels of inflammatory factors such as IL-2 and IFN-c in the severe group were higher than those in the control group and nonsevere group, which may be related to the feedback regulation of inflammatory factors. IL-6 and IL-10 are a class of cellular inflammatory factors secreted by 2 cells, macrophages, vascular endothelial cells, etc., which can inhibit the activation of 1 cells and feedback regulate the release of various cytokines including IL-2 and IFN-c [14]. IL-4 belongs to a class of typical chemokines that can mediate T cell activation and has certain antiviral effects [15].…”

Section: Discussionmentioning

confidence: 99%

Study on the Changes and Significance of Immune State and Cycokines in Children with Adenovirus Pneumonia

Hou

Liu

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To observe the difference between peripheral blood T lymphocytes subsets and cycokines in children with severe adenovirus pneumonia and nonsevere adenovirus pneumonia, and to investigate their clinical value in the prognosis of severe pneumonia. Methods. 215 children with adenovirus pneumonia and 30 healthy volunteers (which was set as the control group) in our hospital from January 2017 to May 2019 were enrolled in the study. There were 47 children with severe pneumonia in the severe group and 168 nonsevere pneumonia children in the nonsevere group. The flow cytometry and ELISA methods were used to detect the serum levels of CD3+, CD4+, CD8+ T cells and interleukin-2 (IL-2), IL-4, IL-6, IL-10, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ). Results. (1) The levels of CD3 (%) T cells, CD4 (%) T cells, and CD4/CD8 ratio values of children with adenovirus pneumonia were lower than these of normal children ( P < 0.05 ). And the levels of CD3 (%) T cells, CD4 (%) T cells, and CD4/CD8 ratio values of children in the severe group were lower than these of children in the nonsevere group ( P < 0.05 ). (2) The levels of IL-2, IL-6, IL-10, TNF-α, and IFN-γ values of children with adenovirus pneumonia were lower than these of normal children ( P < 0.05 ). And the levels of IL-2, IL-6, IL-10, TNF-α, and IFN-γ of children in the severe group were higher than these of children in the nonsevere group ( P < 0.05 ). (3) Among the 47 children with severe adenoviral pneumonia, 39 received systematic treatment in our hospital. According to the treatment effect, 39 children were divided into the effective group (n = 25) and the ineffective group (n = 14). (4) The CD3 (%), CD4 (%), and CD4/CD8 ratios of the children in the effective group were higher than those in the ineffective group ( P < 0.05 ). (5) The levels of IL-2, IL-6, IL-10, TNF-α, and IFN-γ in the effective group were lower than those in the ineffective group ( P < 0.05 ). Conclusion. The immunophenotype of peripheral blood T lymphocytes and cycokines could be helpful to judge the severity of adenovirus pneumonia, which could be used as the objective indexes to evaluate the prognosis of children with severe adenovirus pneumonia.

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Section: Discussionmentioning

confidence: 99%

Study on the Changes and Significance of Immune State and Cycokines in Children with Adenovirus Pneumonia

Hou

Liu

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…We consider recombinant HAdVs as part of the evolutionary process of HAdV-C, therefore we believe that continuous genomic surveillance with viral typing is that typing is not usually performed for the majority of diagnosed cases of HAdV respiratory infection. Only large outbreaks or cases of unusual severity have prompted detailed molecular, etiologic, or epidemiologic investigations [ 90 , 257 ]. We believe that, as it was implemented for Influenza, later in SARS-CoV-2, genomic surveillance should be integrated into the various respiratory viruses with pandemic potential, in the case of HAdV, typing should be included, recognition of modifications in their antigenic proteins, infectious power (viral tropism) and severity of symptoms.…”

Section: Future Projections Of Hadv Study In the 21st Centurymentioning

confidence: 99%

An Old Acquaintance: Could Adenoviruses Be Our Next Pandemic Threat?

Saint-Pierre

Conei

Lizama

et al. 2023

Viruses

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Human adenoviruses (HAdV) are one of the most important pathogens detected in acute respiratory diseases in pediatrics and immunocompromised patients. In 1953, Wallace Rowe described it for the first time in oropharyngeal lymphatic tissue. To date, more than 110 types of HAdV have been described, with different cellular tropisms. They can cause respiratory and gastrointestinal symptoms, even urinary tract inflammation, although most infections are asymptomatic. However, there is a population at risk that can develop serious and even lethal conditions. These viruses have a double-stranded DNA genome, 25–48 kbp, 90 nm in diameter, without a mantle, are stable in the environment, and resistant to fat-soluble detergents. Currently the diagnosis is made with lateral flow immunochromatography or molecular biology through a polymerase chain reaction. This review aimed to highlight the HAdV variability and the pandemic potential that a HAdV3 and 7 recombinant could have considering the aggressive outbreaks produced in health facilities. Herein, we described the characteristics of HAdV, from the infection to treatment, vaccine development, and the evaluation of the social determinants of health associated with HAdV, suggesting the necessary measures for future sanitary control to prevent disasters such as the SARS-CoV-2 pandemic, with an emphasis on the use of recombinant AdV vaccines to control other potential pandemics.

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“…Globally, HAdV-C1, -C2, -B3, -E4, -C5, -C6, -B7, -B14, and -B55 were the main types or genotypes in causing outbreaks [ 11 ]. In Asia, HAdV-B3 and -B7 were the predominant types associated with acute respiratory infections (ARIs) in children [ 11 ], especially among increased HAdV infections in southern China and Beijing during 2018–2019 [ 12 , 13 ]. In America, HAdV-C2 was reported as most frequently detected type in HAdV surveillances [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

The changed endemic pattern of human adenovirus from species B to C among pediatric patients under the pressure of non-pharmaceutical interventions against COVID-19 in Beijing, China

Wang

Zhu

Qian

et al. 2023

Virol J

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Background Under the pressure of non-pharmaceutical interventions (NPIs) targeting severe acute respiratory syndrome coronavirus 2, the prevalence of human adenovirus (HAdV) was monitored before and after NPIs launched on Jan 24, 2020 in pediatric patients in Beijing, China. Methods Respiratory samples collected from children hospitalized with acute respiratory infections from Jan 2015 to Dec 2021 were screened by direct immunofluorescence test or capillary electrophoresis-based multiplex PCR assay. The hexon, penton base, and fiber genes were amplified from HAdV positive specimens, then sequenced. For HAdV typing, phylogenetic trees were built by MEGA X. Then clinical data of HAdV positive cases were collected. All data were evaluated using SPSS Statistics 22.0 software. Results A total of 16,097 children were enrolled and 466 (2.89%, 466/16,097) were HAdV-positive. The positive rates of HAdV varied, ranging from 4.39% (151/3,438) in 2018 to1.25% (26/2,081) in 2021, dropped from 3.19% (428/13,408) to 1.41% (38/2,689) from before to after NPIs launched (P < 0.001). There were 350 cases typed into nine types of species B, C, or E and 34 recorded as undetermined. Among them, HAdV-B3 (51.56%, 198/384) was the most prevalent types from 2015 to 2017, and HAdV-B7 (29.17%, 112/384) co-circulated with HAdV-B3 from 2018 to 2019. After NPIs launched, HAdV-B3 and B7 decreased sharply with HAdV-B7 undetected in 2021, while HAdV-C1 became the dominant one and the undetermined were more. Conclusions The endemic pattern of HAdV changed in Beijing because of the NPIs launched for COVID-19. Especially, the dominant types changed from HAdV-B to HAdV-C.

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Analysis of severe human adenovirus infection outbreak in Guangdong Province, southern China in 2019

Cited by 21 publications

References 38 publications

Study on the Changes and Significance of Immune State and Cycokines in Children with Adenovirus Pneumonia

Study on the Changes and Significance of Immune State and Cycokines in Children with Adenovirus Pneumonia

An Old Acquaintance: Could Adenoviruses Be Our Next Pandemic Threat?

The changed endemic pattern of human adenovirus from species B to C among pediatric patients under the pressure of non-pharmaceutical interventions against COVID-19 in Beijing, China

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