Analysis of Serum Lipid Profile in Patients With Pancreatitis

Abstract

Pancreatitis is one of the most frequent gastrointestinal tract disease for hospitalization all over the world, leading to tremendous emotional, physical and financial human burden. The spectrum of aetiological factors for pancreatitis varies according to continents. Hyperlipidaemia is a rare but known and established risk factor for pancreatitis and goes undetected in most of the clinical settings. Early diagnosis of hyperlipidaemia induced pancreatitis is important to prevent its recurrence and complications. METHODThis is a prospective study carried out on patients with pancreatitis over a period of two years in M.K.C.G. Medical College and Hospital, Berhampur, Odisha, India. Fifty cases of pancreatitis of different age group and both sexes were selected. Equal number of age and sex matched patients other than pancreatitis were taken as control from the indoor. The mean serum lipid profiles of cases were compared with the control group. RESULTIn this study it was observed that the Serum Total Cholesterol, Triglycerides, Low Density Lipoprotein and Very Low Density Lipoprotein were significantly higher in cases than controls, while HDL was found to be higher in controls. Young males were commonly affected and alcohol abuse is the most common risk factor followed by biliary stones. CONCLUSIONAll pancreatitis patients should be evaluated for any alteration in their serum lipid profile, if found to be treated with antilipidaemic drugs, dietary modulation, lifestyle change and physical exercise to limit the occurrence of this disease, pre vent its complications and to control the possibility of future recurrences.

Effect of dried ginger water extract on hypertriglyceridemia induced acute pancreatitis in rats

“…it's also liable for cholesterol homeostasis by transporting excessive cholesterol from tissue to the liver andmore emphasis placed upon its anti-inflammatory effect. 17 In our study, we found that increased TC Level and decreased HDL-C within the disease control group compared with the control group. Ginger extract (200 mg/kg and 400 mg/kg) both doses are reduced TC and increased 'GOOD CHOLESTEROL' (HDL-C) but it doesn't have a big effect on LDL-C level.…”

“…The parameters of lipid profilenamelyTC, LDL-C, are higher and HDL-C is lower in pancreatitis. 17 The protein composition of HDL Apolipoprotein A1 (APO-A1) depleted which is that the major protein component of HDL. it's also liable for cholesterol homeostasis by transporting excessive cholesterol from tissue to the liver andmore emphasis placed upon its anti-inflammatory effect.…”