Analysis of serum level of 25-hydroxycholecalciferol, calcium and lipid profile in carcinoma breast

Abstract

Background: Breast cancer (BC) is one of the major surgical problems in India, particularly in younger females. There are conflicting reports regarding the association between the serum lipid profiles, vitamin D, calcium and BC. The objective of the study was to measure the serum vitamin D, calcium and lipid profile levels in BC, benign breast diseases (BBD) and healthy control (HC), and compared these variables with clinico-pathological parameters in BC patients.Methods: Forty histologically confirmed invasive BC, 20 BBD patients and 20 healthy individuals taken as controls were enrolled for estimation of serum lipid profile, calcium and vitamin D. The study variables were compared with all three groups. In BC group, the levels were also compared with clinico-pathological parameters.Results: The mean age of subjects in BC, BBD and HC group was 48.88±11.33, 31.10±3.93 and 36.30±5.97 years respectively. The levels of serum cholesterol, triglyceride, HDL, LDL, VLDL and calcium was significantly increased and vitamin D was significantly decreased in BC patients as compared with BBD and HC group (p<0.001). On comparing lipid profile, calcium and vitamin D in receptor positive BC patients and triple negative BC patients, only serum HDL and serum calcium was significantly high in receptor positive BC patients (p=0.047 and p=0.041).Conclusions: Our findings suggest that lower vitamin D level and higher calcium and lipid profile level could be an important etiopathological factor in the causation of BC. Correction of these factors could be used as a prophylactic and preventive strategy in the population against BC.

Effects of oral N-acetyl cysteine on pain and plasma biochemical parameters in fibrocystic breast disorder: A randomized controlled trial

“…Regarding benign nature of FCC in association with its slow growth, close observation of the lesion beside therapy of symptoms is considered as the first line of treatment. To date, various herbal and synthetic medications like evening primrose oil; vitagnus; vitamins including D, E, and B; probiotics; metformin; and antioxidant agents have been introduced for prevention of symptoms in FCC, although there is no general consensus on any [ 1 , 6 , [9] , [10] , [11] , [12] ].…”

“…Therefore, identifying suitable medication with sufficient potency to control such pain could be interesting and helpful to recover patients. Based on previous studies that have demonstrated NAC could act as sulfhydryl group donor, restore glutathione, scavenge free radical, and also regulate production of sex hormones including estrogen and progesterone, we hypothesized that NAC could positively change oxidative stress reactions leading to inflammation and following FCC formation [ [8] , [9] , [10] , [11] , [12] ]. According to this hypothesis, this study aims to investigate possible effects of NAC on pain and biochemical parameters related to FCC.…”