Analysis of serum IgE reactivity profiles with microarrayed allergens indicates absence of de novo IgE sensitizations in adults

Lupinek, Christian; Marth, Katharina; Niederberger, Verena; Valenta, Rudolf

doi:10.1016/j.jaci.2012.06.028

Cited by 34 publications

(29 citation statements)

References 9 publications

(9 reference statements)

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“…Earlier studies suggesting that neosensitization occurs during SCIT 38,39 have not been confirmed by others. 40,41 Limitations of our study Only 24 subjects were studied; a bigger study might be needed to confirm our findings. Allergen challenge outcomes had been performed in 10-fold dilution steps.…”

Section: Isac Is a Reproducible Assaymentioning

confidence: 81%

Pretreatment IgE sensitization patterns determine the molecular profile of the IgG4 response during updosing of subcutaneous immunotherapy with timothy grass pollen extract

Schmid

Würtzen

Dahl

et al. 2016

Journal of Allergy and Clinical Immunology

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Section: Isac Is a Reproducible Assaymentioning

confidence: 81%

Pretreatment IgE sensitization patterns determine the molecular profile of the IgG4 response during updosing of subcutaneous immunotherapy with timothy grass pollen extract

Schmid

Würtzen

Dahl

et al. 2016

Journal of Allergy and Clinical Immunology

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“…The control groups thus showed a similar composition regarding age and were also similar regarding the gender balance as compared to the Uzbek groups (Figure ). Neither in the Uzbek nor in the Austrian young groups, subjects below 18 years were included because it has been shown that children up to the age of 12 years can acquire additional sensitizations whereas in adult patients IgE reactivity profiles remain constant . Permission of the local ethics committees was obtained, and written informed consent was obtained from the patients.…”

Section: Methodsmentioning

confidence: 99%

Possible effect of landscape design on IgE recognition profiles of two generations revealed with micro‐arrayed allergens

Garib

Wollmann

Djambekova

et al. 2017

Allergy

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The aim of this study was to investigate possible effects of landscape design on the IgE sensitization profile toward inhalant allergens in patients with respiratory allergy from Uzbekistan where green areas have been changed during the last two decades by a State program. Sera from two different generations of Uzbek (n=58) and, for control purposes, from two generations of Austrian (n=58) patients were analyzed for IgE reactivity to 112 different micro‐arrayed allergen molecules by ImmunoCAP ISAC technology. Changes in molecular IgE sensitization profiles to pollen allergens in the young vs the middle‐aged Uzbek population were associated with replanting, whereas those in the Vienna populations reflected natural changes in plant growth. Our data indicate that anthropologic as well as natural changes in the biome may have effects on IgE sensitization profiles already from one to another generation.

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“…The development of IgE responses to allergen molecules, a process termed "allergic sensitization" seems to occur early in life whereas IgE-reactivity profiles of adult allergic patients do not change in a relevant manner [2,3]. This implies that there exists a period early in life during which allergic sensitization takes place and IgE-reactivity profiles are established.…”

Section: Introductionmentioning

confidence: 99%

“…The ImmunoCAP ISAC has been used in a large number of clinical studies for a number of years [7], in epidemiologic studies [8], longitudinal follow up of children [9] and to find de novo sensitizations [3]. It has many advantages and results are close but not identical to classical immunoassays [10] (WAO Position Paper, in press).…”

Section: Introductionmentioning

confidence: 99%

Advances in allergen-microarray technology for diagnosis and monitoring of allergy: The MeDALL allergen-chip

Lupinek

Wollmann

Baar

et al. 2014

Methods

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Allergy diagnosis based on purified allergen molecules provides detailed information regarding the individual sensitization profile of allergic patients, allows monitoring of the development of allergic disease and of the effect of therapies on the immune response to individual allergen molecules. Allergen microarrays contain a large variety of allergen molecules and thus allow the simultaneous detection of allergic patients' antibody reactivity profiles towards each of the MeDALL is a European research program in which allergen microarray technology is used for the monitoring of the development of allergic disease in childhood, to draw a geographic map of the recognition of clinically relevant allergens in different populations and to establish reactivity profiles which are associated with and predict certain disease manifestations. We describe technical advances of the MeDALL allergen-chip regarding specificity, sensitivity and its ability to deliver test results which are close to in vivo reactivity. In addition, the usefulness and numerous advantages of allergen microarrays for allergy research, refined allergy diagnosis, monitoring of disease, of the effects of therapies, for improving the prescription of specific immunotherapy and for prevention are discussed. Europe PMC Funders Group

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Analysis of serum IgE reactivity profiles with microarrayed allergens indicates absence of de novo IgE sensitizations in adults

Cited by 34 publications

References 9 publications

Pretreatment IgE sensitization patterns determine the molecular profile of the IgG4 response during updosing of subcutaneous immunotherapy with timothy grass pollen extract

Pretreatment IgE sensitization patterns determine the molecular profile of the IgG4 response during updosing of subcutaneous immunotherapy with timothy grass pollen extract

Possible effect of landscape design on IgE recognition profiles of two generations revealed with micro‐arrayed allergens

Advances in allergen-microarray technology for diagnosis and monitoring of allergy: The MeDALL allergen-chip

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