Analysis of serum genome-wide microRNAs for breast cancer detection

Wu, Qian; Wang, Chao; Zhang, Lu; Guo, Li; Ge, Qinyu

doi:10.1016/j.cca.2012.02.016

Cited by 120 publications

(79 citation statements)

References 19 publications

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“…Despite these prevention strategies, all patients must undergo a biopsy or fine needle aspiration for a positive diagnosis. There have been two approaches to analyze circulating miRNA expression in breast cancer: validating single miRNA probes using qRT-PCR [9,[63][64][65][66][67][68][69][70][71] or a genomewide approach such as oligonucleotide arrays or next-generation sequencing [72][73][74][75][76].…”

Section: Breast Cancermentioning

confidence: 99%

Circulating microRNAs: potential biomarkers for common malignancies

Khoury

Tran

2015

Biomark. Med.

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MicroRNAs (miRNAs) belong to a class of small noncoding RNAs (ncRNAs), which regulate gene expression at the post-transcriptional level. They are approximately 22 nucleotide sequences in length and have been predicted to control expression of up to 30-60% of all protein-coding genes in mammals. Considering this wide involvement in gene control, aberrant miRNA expression has a strong association with the presence and progression of a disease, hence generating much anticipation in using miRNAs as biomarkers for the diagnosis and prognosis of human cancers. The majority of these miRNAs are intracellular, but recently they have been discovered in bodily fluids. This review will provide an insight into these circulatory miRNA molecules and discuss their potential as cancer biomarkers.

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Section: Breast Cancermentioning

confidence: 99%

Circulating microRNAs: potential biomarkers for common malignancies

Khoury

Tran

2015

Biomark. Med.

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“…Among these, miR-222 is significantly increased in the serum of BC patients which may serve as a valuable biomarker for differentiating BC patients from normal individuals. 30 One of the major reasons for the mortality in breast cancer is metastasis. 31 Metastasis is a complex process during which a primary solid tumor invades the adjacent tissue and then spreads to the neighboring as well as the distant parts of the body.…”

Section: Micrornas and Breast Cancer Stem Cellsmentioning

confidence: 99%

Role of microRNAs in breast cancer

Singh

Mo²

2013

Cancer Biology & Therapy

131

109

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“…Multiple studies (Table 3) have demonstrated that miRNA biomarkers provide excellent sensitivity and specificity for detecting early-and even advancedstage breast cancer, strongly suggesting that they are potential diagnostic tools for identifying early and advanced breast cancers [206][207][208][209][210][211][212][213][214][215][216][217][218][219][220][221][222][223][224]. The most commonly reported miRNAs in body fluids and best candidates for biomarkers are miR-21, miR-155, miR-10 b, miR-92 a, miR-133 a, miR-145, miR-148 b and miR-451 [207,[211][212][213][214][215][216][217][219][220][221][222][223].…”

Section: Translational Implications Of Ncrnas In Breast Cancermentioning

confidence: 99%

Noncoding RNAs in breast cancer

Lo¹,

Wolfson²,

Zhou³

et al. 2015

Briefings in Functional Genomics

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The mammalian transcriptome has recently been revealed to encompass a large number of noncoding RNAs (ncRNAs) that play a variety of important regulatory roles in gene expression and other biological processes. MicroRNAs (miRNAs), the best studied of the short noncoding RNAs (sncRNAs), have been extensively characterized with regard to their biogenesis, function and importance in tumorigenesis. Another class of sncRNAs called piwi-interacting RNAs (piRNAs) has also gained attention recently in cancer research owing to their critical role in stem cell regulation. Long noncoding RNAs (lncRNAs) of >200 nucleotides in length have recently emerged as key regulators of developmental processes, including mammary gland development. lncRNA dysregulation has also been implicated in the development of various cancers, including breast cancer. In this review, we describe and discuss the roles of sncRNAs (including miRNAs and piRNAs) and lncRNAs in the initiation and progression of breast tumorigenesis, with a focus on outlining the molecular mechanisms of oncogenic and tumor-suppressor ncRNAs. Moreover, the current and potential future applications of ncRNAs to clinical breast cancer research are also discussed, with an emphasis on ncRNA-based diagnosis, prognosis and future therapeutics.

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Analysis of serum genome-wide microRNAs for breast cancer detection

Cited by 120 publications

References 19 publications

Circulating microRNAs: potential biomarkers for common malignancies

Circulating microRNAs: potential biomarkers for common malignancies

Role of microRNAs in breast cancer

Noncoding RNAs in breast cancer

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