Analysis of Serum and Urinal Copper and Zinc in Chinese Northeast Population with the Prediabetes or Diabetes with and without Complications

Xu, Jiancheng; Zhou, Qi; Liu, Gilbert; Tan, Yi; Cai, Lu

doi:10.1155/2013/635214

Cited by 62 publications

(60 citation statements)

References 39 publications

(42 reference statements)

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“…Vashum et al [11] observed a significant association of zinc levels with insulin sensitivity in pre-diabetes even though no significant difference in serum levels was found in their study between pre-diabetes, diabetes and controls. Xu et al [24] also observed a deficiency similar to the present study in pre-diabetes. This spectrum of observations from different studies conducted in different countries could be attributed to the population profiles differing substantially in dietary composition and geographical distribution [24].…”

Section: Discussionsupporting

confidence: 91%

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Association of Serum Selenium, Zinc and Magnesium Levels with Glycaemic Indices and Insulin Resistance in Pre-diabetes: a Cross-Sectional Study from South India

Yadav

Manjrekar

Agarwal

et al. 2016

Biol Trace Elem Res

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A growing understanding of antioxidant mechanisms and insulin-like actions of trace elements selenium and zinc has rekindled researchers' interest towards their role in diabetes mellitus, nutritional management of which concentrates predominantly on macronutrient intake. However, selenium studies limiting largely to diabetes have yielded inconsistent results with sparse knowledge in the pre-diabetes population. This hospital-based cross-sectional study screened 300 people who came to the institutional hospital laboratory with fasting plasma glucose and glycosylated haemoglobin requisition over a period of 6 months. Thirty-five pre-diabetes subjects aged 25-45 years and 35 age-matched healthy controls were selected as per inclusion criteria and clinical history. Serum selenium was estimated by inductively coupled plasma-mass spectrometry, zinc and magnesium by colorimetric end-point methods and insulin by enzyme-linked immunosorbent assay, and insulin resistance was calculated using a homeostasis model assessment (HOMA) 2 calculator. Data analysis was done using SPSS ver. 16 employing an independent sample t test for intergroup comparison of means and Pearson's correlation for correlation analysis. Serum mineral levels in the pre-diabetes group (selenium 63.01 ± 17.6 μg/L, zinc 55.78 ± 13.49 μg/dL, magnesium 1.37 ± 0.38 mg/dL) were significantly reduced (p < 0.05) in comparison to the healthy controls (selenium 90.98 ± 15.81 μg/L, zinc 94.53 ± 15.41 μg/dL, magnesium 2.12 ± 0.22 mg/dL). A significant negative correlation was seen with glycaemic indices and insulin resistance. This study conducted in pre-diabetes subjects highlights a considerable deficiency of serum selenium, zinc and magnesium observed at a much earlier pre-clinical phase. This coupled with the evidence of a strong inverse association with glycaemic indices and insulin resistance postulates the role of mineral alterations in the pathophysiology of hyperglycaemia and insulin resistance.

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Section: Discussionsupporting

confidence: 91%

“…Xu et al [24] also observed a deficiency similar to the present study in pre-diabetes. This spectrum of observations from different studies conducted in different countries could be attributed to the population profiles differing substantially in dietary composition and geographical distribution [24].…”

Section: Discussionsupporting

confidence: 91%

Association of Serum Selenium, Zinc and Magnesium Levels with Glycaemic Indices and Insulin Resistance in Pre-diabetes: a Cross-Sectional Study from South India

Yadav

Manjrekar

Agarwal

et al. 2016

Biol Trace Elem Res

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“…In general, concentrations of Cu were similar between diabetics and controls (27)(28)(29). However, the high levels of Cu found in our patients have been reported by other series (30). This could be, in part, explained by the decrease in Cu affinity to ceruloplasmin because of its glycosylation in the diabetic patients (31).…”

Section: Discussionsupporting

confidence: 81%

Antioxidants status in type 2 diabetic patients in Morocco

Eljaoudi

Elomri

Laamarti³

et al. 2017

Turk J Med Sci

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Background/aim: Type 2 diabetes is a heterogeneous and multifactorial metabolic disorder with some relationship to oxidative stress (OS). Since no studies were conducted in the Moroccan population, this clinical investigation aimed at evaluating the antioxidants status in Moroccan patients with type 2 diabetes.Materials and methods: Blood samples of 60 type 2 diabetic patients and 40 healthy controls subjects were analyzed for determination of glycemia, hemoglobin, CRP, glycated hemoglobin, lipid parameters, malondialdehyde (MDA), vitamins E and C, copper (Cu), zinc (Zn), and selenium (Se).Results: CRP and triglycerides were higher in the diabetic group while high-density lipoprotein levels were significantly lower compared to the control group. Plasma MDA, Cu concentrations, and Cu/Zn ratio were found to be higher in diabetic patients compared to healthy subjects, while vitamin E, Zn, and Se concentrations were lower compared to the control group. No significant difference was found in vitamin C levels between the two groups. Plasma HbA1c was positively correlated to MDA levels. Conclusion:This study shows that antioxidant status is impaired in diabetics compared to healthy controls.

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“…Similar findings were found with zinc levels and insulin, and HOMA-IR levels. Zinc is also a cofactor for insulin biosynthesis and storage in pancreatic β cells [33]. Zinc deficiency may induce abnormal insulin metabolism.…”

Section: Discussionmentioning

confidence: 99%

Trace Element Levels in Congenital Hypogonadotrophic Hypogonadism

Aydoğdu

Haymana

Soykut

et al. 2015

Biol Trace Elem Res

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Cardiometabolic diseases are prevalent in hypogonadism. The pathophysiologic mechanism of increased cardiometabolic risk in hypogonadal patients is not clear. Recently, trace elements have been linked to the development of chronic disease especially cardiovascular disease. We investigated the trace element levels in an unconfounded population of congenital hypogonadotrophic hypogonadism (CHH) and also searched for the relationship with metabolic risk factors. A total of 89 patients with CHH (mean age 21.8 ± 2.0 years) and 80 healthy control subjects (mean age 21.3 ± 1.1 years) were enrolled. The demographic parameters, homeostatic model assessment of insulin resistance (HOMA-IR) levels and plasma zinc, copper, and selenium levels, were measured in patients and healthy controls. The patients had higher waist circumferences (p = 0.014), triglyceride (p = 0.04), insulin (p = 0.004), HOMA-IR levels (p = 0.001), and lower selenium (p = 0.049), zinc (p = 0.004), and copper (p = 0.012) levels when compared to the healthy controls. There was a significant relationship between zinc levels and HOMA-IR levels (p = 0.015). In the regression analysis, zinc levels were independently associated with the calculated HOMA-IR levels (p = 0.015). The results of the present study show that plasma selenium, zinc, and copper levels are decreased in patients with CHH. Also, plasma zinc levels are independently associated with insulin resistance in patients with hypogonadism. Long-term follow-up studies are warranted to investigate the effect of trace elements on the increased cardiometabolic risk in hypogonadism.

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Analysis of Serum and Urinal Copper and Zinc in Chinese Northeast Population with the Prediabetes or Diabetes with and without Complications

Cited by 62 publications

References 39 publications

Association of Serum Selenium, Zinc and Magnesium Levels with Glycaemic Indices and Insulin Resistance in Pre-diabetes: a Cross-Sectional Study from South India

Association of Serum Selenium, Zinc and Magnesium Levels with Glycaemic Indices and Insulin Resistance in Pre-diabetes: a Cross-Sectional Study from South India

Antioxidants status in type 2 diabetic patients in Morocco

Trace Element Levels in Congenital Hypogonadotrophic Hypogonadism

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