Analysis of select members of the E26 (ETS) transcription factors family in colorectal cancer

Deves, Candida; Renck, Daiana; Garicochea, Bernardo; Silva, Vinícius Duval da; Lopes, Tiago Giulianni; Fillman, Henrique; Fillman, Lucio; Lunardini, Silvana; Basso, Luiz Augusto; Santos, Daniel Silas Veras dos; Batista, Evander de Jesus Oliveira

doi:10.1007/s00428-011-1053-6

Cited by 22 publications

(22 citation statements)

References 31 publications

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“…SPIB is an adenoma condition-specific down regulated gene and its expression underwent a striking decrease in CRC tissues indicating that SPIB may serve as potential markers of CRC invasiveness and metastasis [77].…”

Section: Discussionmentioning

confidence: 99%

Identification of Colorectal Cancer Related Genes with mRMR and Shortest Path in Protein-Protein Interaction Network

et al. 2012

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One of the most important and challenging problems in biomedicine and genomics is how to identify the disease genes. In this study, we developed a computational method to identify colorectal cancer-related genes based on (i) the gene expression profiles, and (ii) the shortest path analysis of functional protein association networks. The former has been used to select differentially expressed genes as disease genes for quite a long time, while the latter has been widely used to study the mechanism of diseases. With the existing protein-protein interaction data from STRING ( S earch T ool for the R etrieval of I nteracting G enes), a weighted functional protein association network was constructed. By means of the mRMR ( M aximum R elevance M inimum R edundancy) approach, six genes were identified that can distinguish the colorectal tumors and normal adjacent colonic tissues from their gene expression profiles. Meanwhile, according to the shortest path approach, we further found an additional 35 genes, of which some have been reported to be relevant to colorectal cancer and some are very likely to be relevant to it. Interestingly, the genes we identified from both the gene expression profiles and the functional protein association network have more cancer genes than the genes identified from the gene expression profiles alone. Besides, these genes also had greater functional similarity with the reported colorectal cancer genes than the genes identified from the gene expression profiles alone. All these indicate that our method as presented in this paper is quite promising. The method may become a useful tool, or at least plays a complementary role to the existing method, for identifying colorectal cancer genes. It has not escaped our notice that the method can be applied to identify the genes of other diseases as well.

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Section: Discussionmentioning

confidence: 99%

Identification of Colorectal Cancer Related Genes with mRMR and Shortest Path in Protein-Protein Interaction Network

et al. 2012

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“…For instance, ETV4 is overexpressed at the mRNA and protein level in colorectal tumors and ETV4 overexpression correlates with a shorter survival period of affected patients [153–159]. ETV1 and ETV5 mRNA upregulation is also observable in colorectal tumors, but does not correlate with survival [153].…”

Section: Role In Other Cancersmentioning

confidence: 99%

ETV1, 4 and 5: An oncogenic subfamily of ETS transcription factors

Shin

Janknecht

2012

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

190

242

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The homologous ETV1, ETV4 and ETV5 proteins form the PEA3 subfamily of ETS transcription factors. In Ewing tumors, chromosomal translocations affecting ETV1 or ETV4 are an underlying cause of carcinogenesis. Likewise, chromosomal rearrangements of the ETV1, ETV4 or ETV5 gene occur in prostate tumors and are thought to be one of the major driving forces in the genesis of prostate cancer. In addition, these three ETS proteins are implicated in melanomas, breast and other types of cancer. Complex posttranslational modifications govern the activity of PEA3 factors, which can promote cell proliferation, motility and invasion. Here, we review evidence for a role of ETV1, 4 and 5 as oncoproteins and describe modes of their action. Modulation of their activation or interaction with cofactors as well as inhibiting crucial target gene products may ultimately be exploited to treat various cancers that are dependent on the PEA3 group of ETS transcription factors.

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“…Therefore, better elucidation of invasion and metastasis mechanisms is extremely important to improve the therapeutic efficiency of treatments for breast cancer. V‐ets erythroblastosis virus E26 oncogene homolog 1 (Ets‐1) participates in the migration, invasion and angiogenesis of various cancers, including prostate cancer, colon cancer, liver cancer and neuroblastoma . However, the mechanisms underlying Ets‐1 expression in breast cancer are still unclear.…”

mentioning

confidence: 99%

“…V-ets erythroblastosis virus E26 oncogene homolog 1 (Ets-1) participates in the migration, invasion and angiogenesis of various cancers, including prostate cancer, colon cancer, liver cancer and neuroblastoma. (3,4) However, the mechanisms underlying Ets-1 expression in breast cancer are still unclear.MicroRNA (miRNA) are a novel class of short and small noncoding RNA that take part in post-transcriptional regulation of gene expression through partial complementary binding with the 3 0 -UTR of target mRNA. (5,6) miR-199a-5p has been identified in all tumor types, including testicular cancer, hepatocellular cancer and ovarian cancer, and has been associated with cancer migration, invasion and cell growth on the basis of emerging evidence.…”

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confidence: 99%

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miR‐199a‐5p regulates β1 integrin through Ets‐1 to suppress invasion in breast cancer

Li¹,

Wang

Zhang³

et al. 2016

Cancer Science

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Increasing evidence has revealed that miR‐199a‐5p is actively involved in tumor invasion and metastasis as well as in the decline of breast cancer tissues. In this research, overexpression of miR‐199a‐5p weakened motility and invasion of breast cancer cells MCF‐7 and MDA‐MB‐231. Upregulation of Ets‐1 increased breast cancer cell invasion, but the mechanism by which miR‐199a‐5p modulates activation of Ets‐1 in breast cancer was not clarified. We investigated the relationship between miR‐199a‐5p and Ets‐1 on the basis of 158 primary breast cancer case specimens, and the results showed that Ets‐1 expression was inversely correlated with endogenous miR‐199a‐5p. Overexpression of miR‐199a‐5p reduced the mRNA and protein levels of Ets‐1 in MCF‐7 and MDA‐MB‐231 cells, whereas anti‐miR‐199a‐5p elevated Ets‐1. siRNA‐mediated Ets‐1 knockdown phenocopied the inhibition invasion of miR‐199a‐5p in vitro. Moreover, luciferase reporter assay revealed that miR‐199a‐5p directly targeted 3′‐UTR of Ets‐1 mRNA. This research revealed that miR‐199a‐5p could descend the levels of β1 integrin by targeting 3′‐UTR of Ets‐1 to alleviate the invasion of breast cancer via FAK/Src/Akt/mTOR signaling pathway. Our results provide insight into the regulation of β1 integrin through miR‐199a‐5p‐mediated Ets‐1 silence and will help in designing new therapeutic strategies to inhibit signal pathways induced by miR‐199a‐5p in breast cancer invasion.

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Analysis of select members of the E26 (ETS) transcription factors family in colorectal cancer

Cited by 22 publications

References 31 publications

Identification of Colorectal Cancer Related Genes with mRMR and Shortest Path in Protein-Protein Interaction Network

Identification of Colorectal Cancer Related Genes with mRMR and Shortest Path in Protein-Protein Interaction Network

ETV1, 4 and 5: An oncogenic subfamily of ETS transcription factors

miR‐199a‐5p regulates β1 integrin through Ets‐1 to suppress invasion in breast cancer

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