Analysis of secondary failure time responses in studies with response‐dependent sampling schemes
Yujie Zhong,
Richard J. Cook,
Aiai Yu
Abstract:Response‐dependent sampling is routinely used as an enrichment strategy in the design of family studies investigating the heritable nature of disease. In addition to the response of primary interest, investigators often wish to investigate the association between biomarkers and secondary responses related to possible comorbidities. Statistical analysis regarding genetic biomarkers and their association with the secondary outcome must address the biased sampling scheme involving the primary response. In this ar… Show more
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