Analysis of Salivary Micro-RNAs and Allergen Profile in Patients with Asthma

Zacharias, Jamie; Ishmael, Faoud T.

doi:10.1016/j.jaci.2015.12.1123

Cited by 1 publication

(1 citation statement)

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“…Moreover, the method established in this work showed equal competence or advantages compared with other works for asthma-related miRNA detection (Table S2). , In addition, polarized ECL intensity can also be employed as the detection signal to establish the calibration curve (Figure S15). This showed good sensing performance.…”

Section: Resultsmentioning

confidence: 99%

Dynamically Metasurface-Modulated Electrochemiluminescence Polarization Coupling Angle Strategy for miR-142-3p Detection

Liang,

Wang,

et al. 2023

Anal. Chem.

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The combination of the electrochemiluminescence (ECL) technique with nanophotonics research can spark new analytical and sensing applications. Herein, we developed a novel modulation strategy of the ECL polarization angle based on the dynamically tunable few-layer metasurface. The bilayer metasurface consisted of a fixed Au−Ag core−shell nanocube array (Au@Ag NCA) layer with strong plasmonic hot spots and different amounts of the Au nanoparticles@MoS 2 heterostructure nanosheet (0D-2D HNS) layer with strong metal-support interaction. Due to the interference and near-field coupling between layers, the bilayer metasurface can strongly redistribute the local electromagnetic field and energy in the ECL system, which not only significantly amplified the ECL signal but also modulated the polarization coupling angle. Therefore, the novel ECL polarization angle-resolved sensing strategy has been developed, which was beneficial to improve the sensitivity and resolution of ECL sensing. A dynamically tunable metasurface-based ECL biosensor was successfully used to detect the asthma-related miRNA-142-3p (miR-142-3p). Moreover, the simulation calculations of the electromagnetic field revealed the unique optical activity of the metasurface. This study brought the insightful understanding of the metasurface-modulated optical signal and provided a new idea to construct novel sensing platforms.

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Section: Resultsmentioning

confidence: 99%