Analysis of Rotavirus Antigenemia and Extraintestinal Manifestations in Children With Rotavirus Gastroenteritis

Sugata, Ken; Taniguchi, Koki; Yui, Akiko; Miyake, Fumi; Suga, S.; Asano, Yoshizo; Ohashi, Masahiro; Suzuki, Kyoko; Nishimura, Naoko; Ozaki, Takao; Yoshikawa, Tetsushi

doi:10.1542/peds.2007-2290

Cited by 94 publications

(84 citation statements)

References 24 publications

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“…15 Therefore, systemic manifestations including cutaneous disorders, although rare, may be associated with rotavirus infection. 16 Ruzicka et al, 12 reported the first case of a patient with signs of hepatitis and generalized maculo-papular exanthema which developed one week after his two sons had suffered from rotavirus gastroenteritis.…”

Section: Discussionmentioning

confidence: 99%

Macular exanthema in a child with rotavirus gastroenteritis: A case report

2014

Arch Argent Pediat

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Apart from gastroenteritis, rotavirus has been rarely implicated with some cutaneous disorders such as generalized maculopapular exanthema, infantile acute hemorrhagic edema and Gianotti-Crosti syndrome. We report a 30-month old toddler boy who developed erythematous macular skin eruptions during the course of rotavirus gastroenteritis. To our knowledge, this is the first case in the literature reporting rotavirusrelated macular erythematous lesions in a pediatric patient. We therefore would like to share our experience, to keep rotavirus infection in the differential diagnosis of children with gastroenteritis and erythematous eruption.

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Section: Discussionmentioning

confidence: 99%

Macular exanthema in a child with rotavirus gastroenteritis: A case report

2014

Arch Argent Pediat

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“…Thus, the overall picture that emerges from our findings is that polymorphisms in genes involved in polysaccharide recognition, signal transduction, inhibition of T-cell proliferation, pro-inflammatory signaling and eventual production of antimicrobial peptides are associated with antibody response to the Vi polysaccharide vaccine for typhoid. However, just as co-infection with parasites (Harris et al 2009) or other infectious agents (Sugata et al 2008;Lin et al 2006) can influence immunological response to a pathogen, it is possible, that antibody response to vaccination with Vi polysaccharide may be affected by coinfections or prior exposure. While it is difficult to rule out the involvement of other genes in modulation of immune response to the Vi polysaccharide vaccine, the 7 genes that we have found to be associated with host antibody response to the polysaccharide vaccine provide a foundation for elucidating the functional mechanism of the products of these genes in host response to the polysaccharide vaccine.…”

Section: Discussionmentioning

confidence: 99%

Genetic determinants of immune-response to a polysaccharide vaccine for typhoid

Majumder

Staats

Sarkar-Roy

et al. 2009

HUGO J

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Differences in immunological response among vaccine recipients are determined both by their genetic differences and environmental factors. Knowledge of genetic determinants of immunological response to a vaccine can be used to design a vaccine that circumvents immunogenetic restrictions. The currently available vaccine for typhoid is a pure polysaccharide vaccine, immune response to which is T-cell independent. Little is known about whether genetic variation among vaccinees associates with variation in their antibody response to a polysaccharide vaccine. We conducted a study on 1,000 individuals resident in an area at high-risk for typhoid; vaccinated them with the typhoid vaccine, measured their antibody response to the vaccine, assayed [2,000 curated SNPs chosen from 283 genes that are known to participate in immune-response; and analyzed these data using a strategy to (a) minimize the statistical problems associated with testing of multiple hypotheses, and (b) internally cross-validate inferences, using a half-sample design, with little loss of statistical power. The first stage analysis, using the first half-sample, identified 54 SNPs in 43 genes to be significantly associated with immune response. In the second-stage, these inferences were cross-validated using the second half-sample. First-stage results of only 8 SNPs (out of 54) in 7 genes (out of 43) were cross-validated. We tested additional SNPs in these 7 genes, and found 8 more SNPs to be significantly associated. Haplotypes constructed with these SNPs in these 7 genes also showed significant association. These 7 genes are DEFB1, TLR1, IL1RL1, CTLA4, MAPK8, CD86 and IL17D. The overall picture that has emerged from this study is that (a) immune response to polysaccharide antigens is qualitatively different from that to protein antigens, and (b) polymorphisms in genes involved in polysaccharide recognition, signal transduction, inhibition of T-cell proliferation, pro-inflammatory signaling and eventual production of antimicrobial peptides are associated with antibody response to the polysaccharide vaccine for typhoid.

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“…in that 756 (76.6%) of 987 rotavirus infected patients were classified in the severe state 13) . They also reported that the body temperature and serum levels of rotavirus antigen were higher in the severe state.…”

Section: ㆍ대한소아소화기영양학회지：제 14 권 제 2 호 2011mentioning

confidence: 98%

Distribution of Disease Severity and Group A Rotavirus Genotypes (VP7 & VP4) in Children with Acute Rotavirus Gastroenteritis

Kang

et al. 2011

Korean J Pediatr Gastroenterol Nutr

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Purpose: We aimed to study the distribution of rotavirus genotypes (VP7 and VP4) and disease severity of rotavirus gastroenteritis prevalent in our community. Methods: Stool samples were collected from 156 children who were hospitalized with rotavirus gastroenteritis from December 2007 to June 2008. The disease severity of all patients was scored using the Vesikari scale. After extraction of ds-RNA of the rotavirus, cDNA synthesis using reverse transcription and polymerase chain reaction (RT-PCR) and multiplex PCR was performed. Following this, the final identification of genotypes was performed. Results: Of the 156 samples, VP7(G) and VP4(P) genotypes were identified in 147 (94.2%) and 140 (89.7%) samples, respectively. G1 (116 of 147 samples; 78.9%) and P[8] (137 of 140 samples; 97.9%) were the most prevalent, respectively. Of the 138 samples identified of combination types of VP7 and VP4, G1P[8] (111 samples; 80.4%) was the most prevalent. Other combination types varied with very low distribution rates. 9.4% of genotypes were not included in the new vaccines. The disease severity score was 11.8±3.3 (mean±2SD). The distribution of disease severity was mild or moderate in 37.8% and severe in 62.2% of patients. Conclusion:The most prevalent genotype combination of rotavirus was G1P[8] and genotypes not included in the vaccines represented 9.4% in our community. Disease severity distribution of hospitalized children with rotavirus gastroenteritis was higher in the severe than in the mild and moderate categories.

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Analysis of Rotavirus Antigenemia and Extraintestinal Manifestations in Children With Rotavirus Gastroenteritis

Cited by 94 publications

References 24 publications

Macular exanthema in a child with rotavirus gastroenteritis: A case report

Macular exanthema in a child with rotavirus gastroenteritis: A case report

Genetic determinants of immune-response to a polysaccharide vaccine for typhoid

Distribution of Disease Severity and Group A Rotavirus Genotypes (VP7 & VP4) in Children with Acute Rotavirus Gastroenteritis

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